ko pathway ratio_in_study ratio_in_pop p_value ko04080 Neuroactive ligand-receptor interaction 95/610 423/7206 5.31807868724e-20 ko04724 Glutamatergic synapse 52/610 152/7206 1.28888823257e-19 ko04713 Circadian entrainment 43/610 136/7206 5.46934904167e-15 ko05033 Nicotine addiction 26/610 56/7206 4.60494223897e-14 ko04911 Insulin secretion 37/610 117/7206 4.58322118857e-13 ko04020 Calcium signaling pathway 59/610 265/7206 1.70312611411e-12 ko04720 Long-term potentiation 32/610 99/7206 9.37318417294e-12 ko04024 cAMP signaling pathway 59/610 279/7206 2.82634071401e-11 ko04261 Adrenergic signaling in cardiomyocytes 48/610 205/7206 3.4844537019e-11 ko04728 Dopaminergic synapse 45/610 185/7206 3.74602247601e-11 ko04921 Oxytocin signaling pathway 48/610 209/7206 7.21256471469e-11 ko05031 Amphetamine addiction 28/610 91/7206 6.93603178213e-10 ko05032 Morphine addiction 30/610 110/7206 4.2619584789e-09 ko04744 Phototransduction 16/610 36/7206 8.41777837851e-09 ko04725 Cholinergic synapse 37/610 160/7206 9.62709204605e-09 ko04727 GABAergic synapse 29/610 110/7206 1.79512960582e-08 ko04721 Synaptic vesicle cycle 24/610 80/7206 2.03436546655e-08 ko04970 Salivary secretion 26/610 95/7206 4.31159289432e-08 ko04925 Aldosterone synthesis and secretion 27/610 105/7206 9.85616240007e-08 ko04723 Retrograde endocannabinoid signaling 37/610 175/7206 1.18518216479e-07 ko04745 Phototransduction - fly 15/610 38/7206 1.70040333789e-07 ko04971 Gastric acid secretion 24/610 98/7206 1.33160750405e-06 ko05203 Viral carcinogenesis 5/610 277/7206 4.1796746773e-06 ko04730 Long-term depression 20/610 78/7206 4.77359320126e-06 ko05014 Amyotrophic lateral sclerosis (ALS) 19/610 74/7206 8.06344864119e-06 ko04726 Serotonergic synapse 28/610 137/7206 1.31431253255e-05 ko04022 cGMP-PKG signaling pathway 38/610 216/7206 1.5698811933e-05 ko04260 Cardiac muscle contraction 22/610 98/7206 1.65700784961e-05 ko04742 Taste transduction 16/610 61/7206 3.13191127173e-05 ko05168 Herpes simplex infection 2/610 182/7206 3.30862004254e-05 ko04514 Cell adhesion molecules (CAMs) 26/610 130/7206 3.50732932473e-05 ko04626 Plant-pathogen interaction 8/610 18/7206 5.12576612161e-05 ko03040 Spliceosome 1/610 145/7206 5.98451119739e-05 ko04740 Olfactory transduction 18/610 80/7206 9.33550290244e-05 ko05164 Influenza A 2/610 167/7206 0.000100578082138 ko05169 Epstein-Barr virus infection 4/610 206/7206 0.00011452854322 ko04070 Phosphatidylinositol signaling system 22/610 112/7206 0.000187906412645 ko05322 Systemic lupus erythematosus 2/610 151/7206 0.000299139699897 ko03010 Ribosome 1/610 129/7206 0.00030481288909 ko05030 Cocaine addiction 16/610 73/7206 0.000312033534198 ko04972 Pancreatic secretion 21/610 111/7206 0.000394145911906 ko04072 Phospholipase D signaling pathway 31/610 197/7206 0.000634372506413 ko04010 MAPK signaling pathway 45/610 321/7206 0.000643296489405 ko04360 Axon guidance 35/610 233/7206 0.000714650653327 ko04924 Renin secretion 17/610 86/7206 0.00120900775843 ko05161 Hepatitis B 4/610 173/7206 0.00129079906893 ko04630 Jak-STAT signaling pathway 2/610 132/7206 0.00131375833128 ko04060 Cytokine-cytokine receptor interaction 5/610 191/7206 0.00139854197158 ko04114 Oocyte meiosis 23/610 139/7206 0.00170872011459 ko04960 Aldosterone-regulated sodium reabsorption 10/610 41/7206 0.00176165402837 ko04964 Proximal tubule bicarbonate reclamation 8/610 29/7206 0.00217770378171 ko04014 Ras signaling pathway 38/610 279/7206 0.00290139483779 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 15/610 79/7206 0.00314305976879 ko04922 Glucagon signaling pathway 21/610 128/7206 0.00325141140753 ko04540 Gap junction 21/610 128/7206 0.00325141140753 ko04961 Endocrine and other factor-regulated calcium reabsorption 12/610 59/7206 0.00335493268203 ko04621 NOD-like receptor signaling pathway 4/610 157/7206 0.00350713336577 ko04668 TNF signaling pathway 2/610 120/7206 0.00410712840689 ko04931 Insulin resistance 3/610 137/7206 0.00460922372795 ko05166 HTLV-I infection 12/610 292/7206 0.00493949851113 ko04978 Mineral absorption 9/610 40/7206 0.00528859122332 ko00680 Methane metabolism 8/610 34/7206 0.00632097087878 ko04141 Protein processing in endoplasmic reticulum 6/610 184/7206 0.00686088294679 ko04750 Inflammatory mediator regulation of TRP channels 19/610 122/7206 0.00802800146971 ko04710 Circadian rhythm 9/610 43/7206 0.0086872932113 ko04110 Cell cycle 4/610 145/7206 0.0094869752242 ko04932 Non-alcoholic fatty liver disease (NAFLD) 6/610 182/7206 0.00955863776038 ko05010 Alzheimer's disease 28/610 202/7206 0.00959688215667 ko05200 Pathways in cancer 27/610 492/7206 0.0117554420043 ko04120 Ubiquitin mediated proteolysis 4/610 138/7206 0.0128355045445 ko03008 Ribosome biogenesis in eukaryotes 1/610 79/7206 0.0134058929052 ko04064 NF-kappa B signaling pathway 2/610 96/7206 0.0160100621792 ko04620 Toll-like receptor signaling pathway 2/610 100/7206 0.0166603703388 ko04966 Collecting duct acid secretion 6/610 26/7206 0.0190778246946 ko04711 Circadian rhythm - fly 4/610 13/7206 0.0195855094915 ko00562 Inositol phosphate metabolism 14/610 89/7206 0.0201278131116 ko04210 Apoptosis 7/610 180/7206 0.0208764304288 ko05214 Glioma 13/610 79/7206 0.0219998936259 ko04973 Carbohydrate digestion and absorption 8/610 42/7206 0.0226146751919 ko03013 RNA transport 6/610 166/7206 0.0226870255612 ko04510 Focal adhesion 11/610 240/7206 0.0247479572735 ko00604 Glycosphingolipid biosynthesis - ganglio series 4/610 14/7206 0.0256252159473 ko04214 Apoptosis - fly 1/610 72/7206 0.0296493941397 ko00010 Glycolysis / Gluconeogenesis 12/610 74/7206 0.0315901973194 ko00512 Mucin type O-glycan biosynthesis 6/610 29/7206 0.0317371686235 ko05222 Small cell lung cancer 2/610 89/7206 0.0325730007949 ko05418 Fluid shear stress and atherosclerosis 7/610 173/7206 0.0366253778032 ko05414 Dilated cardiomyopathy 16/610 112/7206 0.0375744217975 ko05034 Alcoholism 29/610 238/7206 0.0433213690833 ko05212 Pancreatic cancer 2/610 83/7206 0.045316735425 ko04912 GnRH signaling pathway 17/610 122/7206 0.0462948987809 ko04350 TGF-beta signaling pathway 3/610 103/7206 0.0469116446926 ko04520 Adherens junction 3/610 103/7206 0.0469116446926 ko04550 Signaling pathways regulating pluripotency of stem cells 7/610 165/7206 0.047174104665