ko pathway ratio_in_study ratio_in_pop p_value ko04621 NOD-like receptor signaling pathway 33/462 157/7206 7.41593100568e-10 ko05340 Primary immunodeficiency 14/462 30/7206 9.18948790515e-10 ko04060 Cytokine-cytokine receptor interaction 34/462 191/7206 3.63771545556e-08 ko04380 Osteoclast differentiation 27/462 134/7206 6.95392926918e-08 ko04650 Natural killer cell mediated cytotoxicity 22/462 97/7206 1.3113469542e-07 ko05164 Influenza A 30/462 167/7206 1.92636059e-07 ko04610 Complement and coagulation cascades 19/462 79/7206 3.59325351467e-07 ko05140 Leishmaniasis 18/462 75/7206 7.57029801065e-07 ko04620 Toll-like receptor signaling pathway 21/462 100/7206 9.9590808743e-07 ko05150 Staphylococcus aureus infection 12/462 36/7206 1.27138901174e-06 ko00120 Primary bile acid biosynthesis 9/462 20/7206 1.5065342232e-06 ko05162 Measles 23/462 120/7206 1.65925902904e-06 ko04064 NF-kappa B signaling pathway 20/462 96/7206 2.06100532218e-06 ko04217 Necroptosis 29/462 178/7206 2.51779890419e-06 ko05145 Toxoplasmosis 23/462 126/7206 3.98040899701e-06 ko05034 Alcoholism 1/462 238/7206 4.62435684904e-06 ko05321 Inflammatory bowel disease (IBD) 14/462 56/7206 7.79202588258e-06 ko05152 Tuberculosis 29/462 187/7206 1.04210033434e-05 ko05133 Pertussis 17/462 87/7206 2.92429862834e-05 ko04660 T cell receptor signaling pathway 21/462 124/7206 3.42614385655e-05 ko04137 Mitophagy - animal 16/462 82/7206 5.09938209345e-05 ko05320 Autoimmune thyroid disease 9/462 29/7206 5.33743969972e-05 ko05330 Allograft rejection 8/462 24/7206 7.91534037038e-05 ko05168 Herpes simplex infection 26/462 182/7206 9.22567236481e-05 ko04728 Dopaminergic synapse 1/462 185/7206 0.000100208824899 ko04146 Peroxisome 16/462 89/7206 0.000142149915792 ko04623 Cytosolic DNA-sensing pathway 10/462 41/7206 0.000196263827262 ko05167 Kaposi's sarcoma-associated herpesvirus infection 26/462 191/7206 0.000234015287805 ko03013 RNA transport 1/462 166/7206 0.000319855818916 ko04612 Antigen processing and presentation 14/462 77/7206 0.000325042733356 ko04630 Jak-STAT signaling pathway 20/462 132/7206 0.000401997633632 ko04662 B cell receptor signaling pathway 15/462 88/7206 0.000416866012581 ko04672 Intestinal immune network for IgA production 9/462 37/7206 0.000418415352587 ko05144 Malaria 10/462 45/7206 0.000443031930987 ko04622 RIG-I-like receptor signaling pathway 12/462 62/7206 0.000475599515188 ko05332 Graft-versus-host disease 6/462 18/7206 0.000642789276379 ko04390 Hippo signaling pathway 2/462 188/7206 0.000704553760836 ko05161 Hepatitis B 23/462 173/7206 0.00075478828132 ko04310 Wnt signaling pathway 2/462 181/7206 0.00100444110499 ko04659 Th17 cell differentiation 16/462 106/7206 0.00108263212762 ko04068 FoxO signaling pathway 22/462 167/7206 0.00111171328398 ko03320 PPAR signaling pathway 12/462 69/7206 0.00128947850721 ko05132 Salmonella infection 15/462 98/7206 0.00132916721071 ko04723 Retrograde endocannabinoid signaling 2/462 175/7206 0.00144969021229 ko05323 Rheumatoid arthritis 14/462 89/7206 0.00145638204412 ko04916 Melanogenesis 1/462 142/7206 0.00149140171851 ko04210 Apoptosis 23/462 180/7206 0.00163309272283 ko00071 Fatty acid degradation 9/462 45/7206 0.0018857413513 ko04668 TNF signaling pathway 17/462 120/7206 0.0019022224868 ko04713 Circadian entrainment 1/462 136/7206 0.00218594762846 ko04724 Glutamatergic synapse 2/462 152/7206 0.0041692580167 ko00362 Benzoate degradation 3/462 6/7206 0.00452518071402 ko04658 Th1 and Th2 cell differentiation 14/462 96/7206 0.00468085261852 ko05206 MicroRNAs in cancer 3/462 177/7206 0.00482173169538 ko04611 Platelet activation 20/462 163/7206 0.00507490694232 ko05142 Chagas disease (American trypanosomiasis) 17/462 130/7206 0.0054219074041 ko05131 Shigellosis 12/462 82/7206 0.00569262450628 ko00592 alpha-Linolenic acid metabolism 5/462 19/7206 0.00581397748476 ko05224 Breast cancer 3/462 174/7206 0.0068880477147 ko05134 Legionellosis 11/462 74/7206 0.00707351433194 ko04062 Chemokine signaling pathway 23/462 201/7206 0.00764100594978 ko04110 Cell cycle 2/462 145/7206 0.00884391850667 ko04145 Phagosome 19/462 162/7206 0.00893940227461 ko05204 Chemical carcinogenesis 8/462 48/7206 0.0104655948424 ko04726 Serotonergic synapse 2/462 137/7206 0.012230549948 ko05020 Prion diseases 7/462 40/7206 0.0125185143525 ko04360 Axon guidance 6/462 233/7206 0.013400390368 ko04666 Fc gamma R-mediated phagocytosis 15/462 122/7206 0.0136671018806 ko04925 Aldosterone synthesis and secretion 1/462 105/7206 0.0143543595061 ko04940 Type I diabetes mellitus 6/462 32/7206 0.0146230005209 ko00051 Fructose and mannose metabolism 7/462 42/7206 0.0162293624649 ko00590 Arachidonic acid metabolism 8/462 52/7206 0.016699653832 ko04540 Gap junction 2/462 128/7206 0.0169639755796 ko03010 Ribosome 2/462 129/7206 0.0170432344491 ko04640 Hematopoietic cell lineage 9/462 64/7206 0.0199903412777 ko05310 Asthma 4/462 17/7206 0.0203378875233 ko00360 Phenylalanine metabolism 4/462 17/7206 0.0203378875233 ko04080 Neuroactive ligand-receptor interaction 16/462 423/7206 0.0237106521047 ko00982 Drug metabolism - cytochrome P450 6/462 37/7206 0.0286704705464 ko05031 Amphetamine addiction 1/462 91/7206 0.0298194101616 ko04664 Fc epsilon RI signaling pathway 10/462 77/7206 0.030332473019 ko04141 Protein processing in endoplasmic reticulum 5/462 184/7206 0.0327116034838 ko04911 Insulin secretion 2/462 117/7206 0.0340057007508 ko04114 Oocyte meiosis 3/462 139/7206 0.0347169442097 ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis 2/462 5/7206 0.0360291596014 ko00281 Geraniol degradation 2/462 5/7206 0.0360291596014 ko00380 Tryptophan metabolism 7/462 50/7206 0.0388225512342 ko00980 Metabolism of xenobiotics by cytochrome P450 6/462 40/7206 0.0403270804343 ko04670 Leukocyte transendothelial migration 16/462 151/7206 0.0424664676665 ko00140 Steroid hormone biosynthesis 6/462 41/7206 0.0447909091116 ko04727 GABAergic synapse 2/462 110/7206 0.0474350758167 ko05032 Morphine addiction 2/462 110/7206 0.0474350758167 ko00983 Drug metabolism - other enzymes 6/462 42/7206 0.0495511668856