ko pathway ratio_in_study ratio_in_pop p_value ko04060 Cytokine-cytokine receptor interaction 51/542 191/7206 2.46497600457e-16 ko04380 Osteoclast differentiation 39/542 134/7206 4.48402210966e-14 ko05321 Inflammatory bowel disease (IBD) 20/542 56/7206 1.44152702699e-09 ko05140 Leishmaniasis 23/542 75/7206 2.63080720308e-09 ko05340 Primary immunodeficiency 14/542 30/7206 7.42074326961e-09 ko04672 Intestinal immune network for IgA production 15/542 37/7206 2.28400896811e-08 ko04064 NF-kappa B signaling pathway 24/542 96/7206 9.92897506363e-08 ko04650 Natural killer cell mediated cytotoxicity 24/542 97/7206 1.2280824898e-07 ko04621 NOD-like receptor signaling pathway 32/542 157/7206 1.41343293659e-07 ko05162 Measles 27/542 120/7206 1.66887716136e-07 ko04659 Th17 cell differentiation 25/542 106/7206 1.83217539372e-07 ko05164 Influenza A 33/542 167/7206 1.9421297022e-07 ko04658 Th1 and Th2 cell differentiation 23/542 96/7206 4.21479583442e-07 ko04620 Toll-like receptor signaling pathway 22/542 100/7206 3.49210747171e-06 ko04610 Complement and coagulation cascades 19/542 79/7206 4.03554061627e-06 ko04660 T cell receptor signaling pathway 25/542 124/7206 4.11667816604e-06 ko04630 Jak-STAT signaling pathway 26/542 132/7206 4.16541573878e-06 ko05168 Herpes simplex infection 32/542 182/7206 4.91022345928e-06 ko05145 Toxoplasmosis 25/542 126/7206 5.56289507312e-06 ko04668 TNF signaling pathway 24/542 120/7206 7.4147524244e-06 ko05152 Tuberculosis 32/542 187/7206 8.24334082208e-06 ko05150 Staphylococcus aureus infection 11/542 36/7206 4.17343797044e-05 ko04710 Circadian rhythm 12/542 43/7206 5.11834903427e-05 ko04640 Hematopoietic cell lineage 15/542 64/7206 5.77668303871e-05 ko05160 Hepatitis C 26/542 153/7206 6.87848454094e-05 ko04070 Phosphatidylinositol signaling system 21/542 112/7206 7.47549124204e-05 ko04662 B cell receptor signaling pathway 18/542 88/7206 7.51098056199e-05 ko05161 Hepatitis B 28/542 173/7206 9.88710812811e-05 ko04062 Chemokine signaling pathway 31/542 201/7206 0.000106523345183 ko05167 Kaposi's sarcoma-associated herpesvirus infection 30/542 191/7206 0.000119007008695 ko05310 Asthma 7/542 17/7206 0.000130845860969 ko04217 Necroptosis 28/542 178/7206 0.000147461940775 ko05330 Allograft rejection 8/542 24/7206 0.000242713995957 ko05142 Chagas disease (American trypanosomiasis) 22/542 130/7206 0.000278422778606 ko05323 Rheumatoid arthritis 17/542 89/7206 0.000283353566323 ko03040 Spliceosome 1/542 145/7206 0.000321074749855 ko00120 Primary bile acid biosynthesis 7/542 20/7206 0.000427313368143 ko04933 AGE-RAGE signaling pathway in diabetic complications 22/542 135/7206 0.000444828208076 ko03013 RNA transport 2/542 166/7206 0.00046712238001 ko04657 IL-17 signaling pathway 16/542 87/7206 0.000659735971582 ko05133 Pertussis 16/542 87/7206 0.000659735971582 ko00051 Fructose and mannose metabolism 10/542 42/7206 0.000868493138388 ko05230 Central carbon metabolism in cancer 15/542 81/7206 0.000894735259092 ko03010 Ribosome 1/542 129/7206 0.00101711683422 ko00590 Arachidonic acid metabolism 11/542 52/7206 0.00139260505199 ko05144 Malaria 10/542 45/7206 0.00153467887267 ko04664 Fc epsilon RI signaling pathway 14/542 77/7206 0.0015815679178 ko04622 RIG-I-like receptor signaling pathway 12/542 62/7206 0.00193360394244 ko04072 Phospholipase D signaling pathway 27/542 197/7206 0.00223630533214 ko04666 Fc gamma R-mediated phagocytosis 19/542 122/7206 0.00251015343805 ko04670 Leukocyte transendothelial migration 22/542 151/7206 0.00254695896774 ko05231 Choline metabolism in cancer 20/542 134/7206 0.00260511268468 ko00140 Steroid hormone biosynthesis 9/542 41/7206 0.00285967295707 ko04623 Cytosolic DNA-sensing pathway 9/542 41/7206 0.00285967295707 ko05146 Amoebiasis 16/542 99/7206 0.00312770379307 ko04068 FoxO signaling pathway 23/542 167/7206 0.00426145864435 ko05320 Autoimmune thyroid disease 7/542 29/7206 0.00475288790063 ko04611 Platelet activation 22/542 163/7206 0.00635685314283 ko05418 Fluid shear stress and atherosclerosis 23/542 173/7206 0.0077148563254 ko05332 Graft-versus-host disease 5/542 18/7206 0.00889085148668 ko05166 HTLV-I infection 34/542 292/7206 0.00902772810823 ko05131 Shigellosis 13/542 82/7206 0.00932229718731 ko03015 mRNA surveillance pathway 1/542 93/7206 0.00945195745629 ko05132 Salmonella infection 15/542 98/7206 0.0101850702896 ko00592 alpha-Linolenic acid metabolism 5/542 19/7206 0.0113351933976 ko04711 Circadian rhythm - fly 4/542 13/7206 0.0130863010659 ko04391 Hippo signaling pathway - fly 1/542 90/7206 0.0139749572662 ko04612 Antigen processing and presentation 12/542 77/7206 0.0141124007975 ko04145 Phagosome 21/542 162/7206 0.0145632976921 ko04930 Type II diabetes mellitus 9/542 54/7206 0.0181944719662 ko00564 Glycerophospholipid metabolism 14/542 99/7206 0.0193949462128 ko05034 Alcoholism 9/542 238/7206 0.02378709081 ko02010 ABC transporters 7/542 39/7206 0.0244351058269 ko05134 Legionellosis 11/542 74/7206 0.0245513138593 ko05215 Prostate cancer 15/542 111/7206 0.0268101194951 ko04940 Type I diabetes mellitus 6/542 32/7206 0.0297431778436 ko04137 Mitophagy - animal 12/542 82/7206 0.0311264791952 ko04960 Aldosterone-regulated sodium reabsorption 7/542 41/7206 0.0313956671717 ko05220 Chronic myeloid leukemia 12/542 85/7206 0.0344263080281 ko00565 Ether lipid metabolism 7/542 42/7206 0.0353282477886 ko04917 Prolactin signaling pathway 12/542 87/7206 0.0374793753071 ko00562 Inositol phosphate metabolism 12/542 89/7206 0.0412254807068 ko04210 Apoptosis 21/542 180/7206 0.0433986992935