ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	206/1210	423/7206	5.19129972387e-56
ko04724	Glutamatergic synapse	90/1210	152/7206	7.95750343813e-33
ko05033	Nicotine addiction	47/1210	56/7206	2.84210370283e-28
ko04713	Circadian entrainment	79/1210	136/7206	4.06407005653e-28
ko05032	Morphine addiction	68/1210	110/7206	1.35833059654e-26
ko04727	GABAergic synapse	65/1210	110/7206	6.8707791099e-24
ko04728	Dopaminergic synapse	87/1210	185/7206	3.1021868475e-22
ko04725	Cholinergic synapse	77/1210	160/7206	1.48351874654e-20
ko04721	Synaptic vesicle cycle	50/1210	80/7206	3.74738096586e-20
ko04020	Calcium signaling pathway	106/1210	265/7206	5.63445426258e-20
ko04024	cAMP signaling pathway	108/1210	279/7206	3.76926046376e-19
ko04723	Retrograde endocannabinoid signaling	78/1210	175/7206	2.67454588662e-18
ko04911	Insulin secretion	59/1210	117/7206	3.10331926147e-17
ko04742	Taste transduction	39/1210	61/7206	1.74386646322e-16
ko04726	Serotonergic synapse	64/1210	137/7206	1.84992832321e-16
ko04921	Oxytocin signaling pathway	81/1210	209/7206	1.19918758958e-14
ko04970	Salivary secretion	46/1210	95/7206	6.89305222877e-13
ko05031	Amphetamine addiction	43/1210	91/7206	1.10676902028e-11
ko04261	Adrenergic signaling in cardiomyocytes	74/1210	205/7206	1.40947864924e-11
ko04720	Long-term potentiation	45/1210	99/7206	1.94564553446e-11
ko04744	Phototransduction	24/1210	36/7206	3.29670193589e-11
ko04740	Olfactory transduction	38/1210	80/7206	1.46105170739e-10
ko04022	cGMP-PKG signaling pathway	72/1210	216/7206	1.5327076175e-09
ko03040	Spliceosome	2/1210	145/7206	1.55401662381e-09
ko04925	Aldosterone synthesis and secretion	43/1210	105/7206	3.07646680832e-09
ko04971	Gastric acid secretion	40/1210	98/7206	1.22695392771e-08
ko05203	Viral carcinogenesis	16/1210	277/7206	4.02075304032e-08
ko05030	Cocaine addiction	31/1210	73/7206	1.85580591552e-07
ko05322	Systemic lupus erythematosus	5/1210	151/7206	3.91571959045e-07
ko04360	Axon guidance	70/1210	233/7206	4.05582217553e-07
ko03013	RNA transport	7/1210	166/7206	8.51610713892e-07
ko05168	Herpes simplex infection	9/1210	182/7206	1.60107742481e-06
ko04060	Cytokine-cytokine receptor interaction	10/1210	191/7206	1.74401545523e-06
ko04972	Pancreatic secretion	39/1210	111/7206	2.23845705097e-06
ko04540	Gap junction	43/1210	128/7206	3.35411755511e-06
ko04010	MAPK signaling pathway	86/1210	321/7206	3.82870285493e-06
ko04514	Cell adhesion molecules (CAMs)	43/1210	130/7206	4.39366512212e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	29/1210	74/7206	4.49184540765e-06
ko04730	Long-term depression	29/1210	78/7206	1.18688479464e-05
ko04621	NOD-like receptor signaling pathway	8/1210	157/7206	1.19399938945e-05
ko05164	Influenza A	9/1210	167/7206	1.3041430961e-05
ko04924	Renin secretion	31/1210	86/7206	1.41323089654e-05
ko04750	Inflammatory mediator regulation of TRP channels	39/1210	122/7206	3.88183999573e-05
ko04120	Ubiquitin mediated proteolysis	7/1210	138/7206	4.45021397957e-05
ko04745	Phototransduction - fly	17/1210	38/7206	4.9994003107e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1210	79/7206	5.19993983695e-05
ko04141	Protein processing in endoplasmic reticulum	12/1210	184/7206	5.24737807479e-05
ko04976	Bile secretion	28/1210	80/7206	6.38633646199e-05
ko04110	Cell cycle	8/1210	145/7206	6.77982877586e-05
ko04966	Collecting duct acid secretion	13/1210	26/7206	9.4985798362e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1210	79/7206	0.000110200044541
ko05110	Vibrio cholerae infection	23/1210	63/7206	0.000133596437343
ko04961	Endocrine and other factor-regulated calcium reabsorption	22/1210	59/7206	0.000140026716565
ko04072	Phospholipase D signaling pathway	54/1210	197/7206	0.000143654107056
ko05414	Dilated cardiomyopathy	35/1210	112/7206	0.000166779446208
ko04070	Phosphatidylinositol signaling system	35/1210	112/7206	0.000166779446208
ko05169	Epstein-Barr virus infection	16/1210	206/7206	0.00020040219696
ko04371	Apelin signaling pathway	49/1210	177/7206	0.000219702059508
ko04014	Ras signaling pathway	70/1210	279/7206	0.000305872393563
ko04260	Cardiac muscle contraction	31/1210	98/7206	0.000307715979017
ko04064	NF-kappa B signaling pathway	5/1210	96/7206	0.00088265325814
ko04612	Antigen processing and presentation	3/1210	77/7206	0.00102994842071
ko05161	Hepatitis B	14/1210	173/7206	0.00129359338921
ko04964	Proximal tubule bicarbonate reclamation	12/1210	29/7206	0.0014992203002
ko05140	Leishmaniasis	3/1210	75/7206	0.00153173849532
ko04923	Regulation of lipolysis in adipocytes	24/1210	77/7206	0.00179997227888
ko00240	Pyrimidine metabolism	7/1210	110/7206	0.00182916170304
ko04915	Estrogen signaling pathway	36/1210	131/7206	0.00195799396978
ko04146	Peroxisome	5/1210	89/7206	0.00248016457718
ko04217	Necroptosis	16/1210	178/7206	0.00420874949168
ko05162	Measles	9/1210	120/7206	0.00431599059762
ko05144	Malaria	1/1210	45/7206	0.00432776090223
ko00071	Fatty acid degradation	1/1210	45/7206	0.00432776090223
ko05410	Hypertrophic cardiomyopathy (HCM)	28/1210	100/7206	0.00435986432828
ko04916	Melanogenesis	37/1210	142/7206	0.00441068843687
ko03420	Nucleotide excision repair	1/1210	46/7206	0.00448315024607
ko04626	Plant-pathogen interaction	8/1210	18/7206	0.00553539315052
ko04270	Vascular smooth muscle contraction	39/1210	154/7206	0.00620894044956
ko04630	Jak-STAT signaling pathway	11/1210	132/7206	0.0066106353225
ko00310	Lysine degradation	4/1210	73/7206	0.00675828481799
ko03022	Basal transcription factors	1/1210	44/7206	0.00693377546319
ko04115	p53 signaling pathway	4/1210	74/7206	0.00697892558724
ko04658	Th1 and Th2 cell differentiation	7/1210	96/7206	0.00879953260494
ko00330	Arginine and proline metabolism	3/1210	61/7206	0.0090798485052
ko04657	IL-17 signaling pathway	6/1210	87/7206	0.00920686474529
ko05133	Pertussis	6/1210	87/7206	0.00920686474529
ko04330	Notch signaling pathway	3/1210	62/7206	0.00931094390047
ko04622	RIG-I-like receptor signaling pathway	3/1210	62/7206	0.00931094390047
ko04610	Complement and coagulation cascades	5/1210	79/7206	0.00946210653696
ko05205	Proteoglycans in cancer	30/1210	271/7206	0.00997666794057
ko05215	Prostate cancer	9/1210	111/7206	0.010351736298
ko04710	Circadian rhythm	14/1210	43/7206	0.0118628609039
ko04912	GnRH signaling pathway	31/1210	122/7206	0.0140996094871
ko03410	Base excision repair	1/1210	38/7206	0.0147859061873
ko05166	HTLV-I infection	34/1210	292/7206	0.0162318752014
ko04930	Type II diabetes mellitus	16/1210	54/7206	0.0166523638357
ko05131	Shigellosis	6/1210	82/7206	0.0171507284587
ko03018	RNA degradation	6/1210	84/7206	0.0176145816591
ko00260	Glycine, serine and threonine metabolism	2/1210	48/7206	0.0179361731399
ko05219	Bladder cancer	2/1210	48/7206	0.0179361731399
ko05321	Inflammatory bowel disease (IBD)	3/1210	56/7206	0.018464292135
ko04918	Thyroid hormone synthesis	23/1210	86/7206	0.0191980671197
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1210	14/7206	0.0196515513891
ko04932	Non-alcoholic fatty liver disease (NAFLD)	19/1210	182/7206	0.0203937422605
ko04973	Carbohydrate digestion and absorption	13/1210	42/7206	0.0210557459935
ko05222	Small cell lung cancer	7/1210	89/7206	0.0216766721239
ko04214	Apoptosis - fly	5/1210	72/7206	0.0250894359465
ko00280	Valine, leucine and isoleucine degradation	3/1210	54/7206	0.0264495672799
ko05145	Toxoplasmosis	12/1210	126/7206	0.0295632671001
ko04922	Glucagon signaling pathway	31/1210	128/7206	0.0308879791661
ko04015	Rap1 signaling pathway	60/1210	278/7206	0.0332047178693
ko03320	PPAR signaling pathway	5/1210	69/7206	0.034013172255
ko00380	Tryptophan metabolism	3/1210	50/7206	0.0367686429414
ko00590	Arachidonic acid metabolism	3/1210	52/7206	0.0379291077046
ko05418	Fluid shear stress and atherosclerosis	19/1210	173/7206	0.0391318615584
ko04620	Toll-like receptor signaling pathway	9/1210	100/7206	0.0419126114722
ko01200	Carbon metabolism	13/1210	128/7206	0.0423173208984
ko04210	Apoptosis	20/1210	180/7206	0.042756983343
ko01524	Platinum drug resistance	6/1210	76/7206	0.0430969892364
ko05340	Primary immunodeficiency	1/1210	30/7206	0.0486459530375