ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	210/1305	423/7206	5.89705038614e-53
ko04724	Glutamatergic synapse	96/1305	152/7206	1.78754000119e-35
ko05033	Nicotine addiction	49/1305	56/7206	1.27097650215e-29
ko05032	Morphine addiction	72/1305	110/7206	2.90373605136e-28
ko04713	Circadian entrainment	80/1305	136/7206	1.16958589512e-26
ko04727	GABAergic synapse	70/1305	110/7206	2.16815938823e-26
ko04728	Dopaminergic synapse	91/1305	185/7206	1.51838069747e-22
ko04725	Cholinergic synapse	81/1305	160/7206	3.43650518088e-21
ko04721	Synaptic vesicle cycle	52/1305	80/7206	1.63567992614e-20
ko04020	Calcium signaling pathway	108/1305	265/7206	1.46687565861e-18
ko04723	Retrograde endocannabinoid signaling	80/1305	175/7206	1.64366416769e-17
ko04911	Insulin secretion	61/1305	117/7206	4.85281627657e-17
ko04024	cAMP signaling pathway	109/1305	279/7206	5.64736603579e-17
ko04726	Serotonergic synapse	67/1305	137/7206	1.02422934223e-16
ko04921	Oxytocin signaling pathway	85/1305	209/7206	9.09753310257e-15
ko05031	Amphetamine addiction	48/1305	91/7206	6.24659532429e-14
ko04742	Taste transduction	37/1305	61/7206	1.4586395165e-13
ko04720	Long-term potentiation	50/1305	99/7206	1.73786220718e-13
ko04744	Phototransduction	26/1305	36/7206	1.60365093753e-12
ko04740	Olfactory transduction	42/1305	80/7206	2.91099918266e-12
ko04970	Salivary secretion	45/1305	95/7206	4.80597938008e-11
ko03010	Ribosome	1/1305	129/7206	2.09861896757e-10
ko04261	Adrenergic signaling in cardiomyocytes	74/1305	205/7206	5.14540272854e-10
ko03040	Spliceosome	3/1305	145/7206	2.39073290608e-09
ko04925	Aldosterone synthesis and secretion	44/1305	105/7206	1.02949599916e-08
ko05030	Cocaine addiction	34/1305	73/7206	1.94781366331e-08
ko04022	cGMP-PKG signaling pathway	73/1305	216/7206	2.44133411073e-08
ko05322	Systemic lupus erythematosus	5/1305	151/7206	4.34879564471e-08
ko03013	RNA transport	7/1305	166/7206	1.09067787349e-07
ko05168	Herpes simplex infection	9/1305	182/7206	1.53704536512e-07
ko04971	Gastric acid secretion	40/1305	98/7206	1.70671874549e-07
ko04360	Axon guidance	73/1305	233/7206	6.21952928603e-07
ko04730	Long-term depression	33/1305	78/7206	6.79566248439e-07
ko04966	Collecting duct acid secretion	16/1305	26/7206	1.04446954947e-06
ko04540	Gap junction	46/1305	128/7206	1.23541459805e-06
ko04070	Phosphatidylinositol signaling system	42/1305	112/7206	1.29805421834e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	31/1305	74/7206	1.84492707244e-06
ko04060	Cytokine-cytokine receptor interaction	12/1305	191/7206	2.32499498578e-06
ko04110	Cell cycle	7/1305	145/7206	3.15630929493e-06
ko05203	Viral carcinogenesis	23/1305	277/7206	3.36544257183e-06
ko04072	Phospholipase D signaling pathway	62/1305	197/7206	4.97147216371e-06
ko04621	NOD-like receptor signaling pathway	9/1305	157/7206	7.92750797281e-06
ko04972	Pancreatic secretion	40/1305	111/7206	8.3555508643e-06
ko04976	Bile secretion	31/1305	80/7206	1.24065940516e-05
ko04010	MAPK signaling pathway	88/1305	321/7206	2.9035933972e-05
ko04371	Apelin signaling pathway	54/1305	177/7206	4.41915067075e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1305	79/7206	4.49814843326e-05
ko04141	Protein processing in endoplasmic reticulum	14/1305	184/7206	5.98030982148e-05
ko05164	Influenza A	12/1305	167/7206	6.2948443074e-05
ko04750	Inflammatory mediator regulation of TRP channels	40/1305	122/7206	7.50886087357e-05
ko04514	Cell adhesion molecules (CAMs)	42/1305	130/7206	7.60746918307e-05
ko04120	Ubiquitin mediated proteolysis	9/1305	138/7206	0.000121917846704
ko04014	Ras signaling pathway	76/1305	279/7206	0.00012808788792
ko04745	Phototransduction - fly	17/1305	38/7206	0.000133872341646
ko04924	Renin secretion	30/1305	86/7206	0.000185814706851
ko04610	Complement and coagulation cascades	3/1305	79/7206	0.000309071093415
ko00520	Amino sugar and nucleotide sugar metabolism	1/1305	55/7206	0.000328041649244
ko05110	Vibrio cholerae infection	23/1305	63/7206	0.000445779218036
ko04961	Endocrine and other factor-regulated calcium reabsorption	22/1305	59/7206	0.000477102592275
ko04915	Estrogen signaling pathway	40/1305	131/7206	0.00050948504585
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1305	79/7206	0.000578632404665
ko04964	Proximal tubule bicarbonate reclamation	13/1305	29/7206	0.000805278892607
ko05169	Epstein-Barr virus infection	20/1305	206/7206	0.000900789912544
ko04922	Glucagon signaling pathway	38/1305	128/7206	0.00111862632725
ko05162	Measles	9/1305	120/7206	0.00117498752944
ko04612	Antigen processing and presentation	4/1305	77/7206	0.00152676649213
ko00240	Pyrimidine metabolism	8/1305	110/7206	0.0016577359162
ko05414	Dilated cardiomyopathy	34/1305	112/7206	0.00175061340549
ko03420	Nucleotide excision repair	1/1305	46/7206	0.00175530366576
ko05140	Leishmaniasis	4/1305	75/7206	0.00220711961612
ko04260	Cardiac muscle contraction	30/1305	98/7206	0.00222155243098
ko04710	Circadian rhythm	16/1305	43/7206	0.00253860019458
ko03022	Basal transcription factors	1/1305	44/7206	0.00266606835136
ko04270	Vascular smooth muscle contraction	43/1305	154/7206	0.00283316792141
ko05231	Choline metabolism in cancer	38/1305	134/7206	0.0030735719963
ko04146	Peroxisome	6/1305	89/7206	0.00328918315537
ko04622	RIG-I-like receptor signaling pathway	3/1305	62/7206	0.00419251165537
ko04064	NF-kappa B signaling pathway	7/1305	96/7206	0.00458586611351
ko04657	IL-17 signaling pathway	6/1305	87/7206	0.0046071069765
ko05133	Pertussis	6/1305	87/7206	0.0046071069765
ko05205	Proteoglycans in cancer	32/1305	271/7206	0.00482881794054
ko03018	RNA degradation	6/1305	84/7206	0.00631210625454
ko04960	Aldosterone-regulated sodium reabsorption	15/1305	41/7206	0.00659550968752
ko04930	Type II diabetes mellitus	18/1305	54/7206	0.00683544445373
ko04973	Carbohydrate digestion and absorption	15/1305	42/7206	0.0073057463123
ko05214	Glioma	24/1305	79/7206	0.00753627829836
ko05321	Inflammatory bowel disease (IBD)	3/1305	56/7206	0.0085446046833
ko04912	GnRH signaling pathway	34/1305	122/7206	0.00854657680874
ko05131	Shigellosis	6/1305	82/7206	0.00876117822806
ko04626	Plant-pathogen interaction	8/1305	18/7206	0.00886819906404
ko00630	Glyoxylate and dicarboxylate metabolism	1/1305	38/7206	0.00948479574399
ko03410	Base excision repair	1/1305	38/7206	0.00948479574399
ko05145	Toxoplasmosis	12/1305	126/7206	0.00987175353965
ko04658	Th1 and Th2 cell differentiation	8/1305	96/7206	0.0106358100634
ko04923	Regulation of lipolysis in adipocytes	23/1305	77/7206	0.0107976786562
ko04015	Rap1 signaling pathway	67/1305	278/7206	0.0108192910209
ko04213	Longevity regulating pathway - multiple species	25/1305	86/7206	0.0109868018423
ko04918	Thyroid hormone synthesis	25/1305	86/7206	0.0109868018423
ko05144	Malaria	2/1305	45/7206	0.0112744089114
ko00071	Fatty acid degradation	2/1305	45/7206	0.0112744089114
ko00562	Inositol phosphate metabolism	26/1305	89/7206	0.0117647156733
ko00280	Valine, leucine and isoleucine degradation	3/1305	54/7206	0.0122607519571
ko04330	Notch signaling pathway	4/1305	62/7206	0.0125554059964
ko05166	HTLV-I infection	37/1305	292/7206	0.0128930013317
ko04217	Necroptosis	20/1305	178/7206	0.0136706501791
ko05217	Basal cell carcinoma	5/1305	68/7206	0.0171530979588
ko00590	Arachidonic acid metabolism	3/1305	52/7206	0.0175986242412
ko04916	Melanogenesis	37/1305	142/7206	0.0201299645648
ko05161	Hepatitis B	20/1305	173/7206	0.0214697456231
ko04630	Jak-STAT signaling pathway	14/1305	132/7206	0.0222211738975
ko04115	p53 signaling pathway	6/1305	74/7206	0.0222542029618
ko00860	Porphyrin and chlorophyll metabolism	1/1305	34/7206	0.0222690498
ko04210	Apoptosis	21/1305	180/7206	0.0236949574627
ko05410	Hypertrophic cardiomyopathy (HCM)	27/1305	100/7206	0.0256310160313
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1305	14/7206	0.0279294216663
ko04214	Apoptosis - fly	6/1305	72/7206	0.030277994739
ko05016	Huntington's disease	27/1305	215/7206	0.0308529197897
ko00310	Lysine degradation	6/1305	73/7206	0.0308839049177
ko04932	Non-alcoholic fatty liver disease (NAFLD)	22/1305	182/7206	0.0318057486558
ko00480	Glutathione metabolism	4/1305	55/7206	0.0342993547106
ko04620	Toll-like receptor signaling pathway	10/1305	100/7206	0.0355560556588
ko00980	Metabolism of xenobiotics by cytochrome P450	2/1305	40/7206	0.036302232732
ko04071	Sphingolipid signaling pathway	40/1305	162/7206	0.0382814260567
ko04062	Chemokine signaling pathway	48/1305	201/7206	0.0403721902641
ko03320	PPAR signaling pathway	6/1305	69/7206	0.0406940952098
ko04113	Meiosis - yeast	6/1305	70/7206	0.0411086544519
ko05230	Central carbon metabolism in cancer	22/1305	81/7206	0.041318936344
ko05132	Salmonella infection	10/1305	98/7206	0.0463801828773
ko05034	Alcoholism	55/1305	238/7206	0.0485719738099
ko04152	AMPK signaling pathway	39/1305	161/7206	0.0487155226773
ko04919	Thyroid hormone signaling pathway	35/1305	143/7206	0.0487290982553
ko00010	Glycolysis / Gluconeogenesis	20/1305	74/7206	0.049269214078
ko01524	Platinum drug resistance	7/1305	76/7206	0.0499588112399