ko pathway ratio_in_study ratio_in_pop p_value ko00120 Primary bile acid biosynthesis 13/646 20/7206 9.23518844497e-10 ko04060 Cytokine-cytokine receptor interaction 41/646 191/7206 9.03680172295e-08 ko05150 Staphylococcus aureus infection 14/646 36/7206 1.10614939419e-06 ko04610 Complement and coagulation cascades 21/646 79/7206 3.69440346958e-06 ko00350 Tyrosine metabolism 12/646 33/7206 1.47744124784e-05 ko03013 RNA transport 2/646 166/7206 4.47215523646e-05 ko00360 Phenylalanine metabolism 8/646 17/7206 4.67124955914e-05 ko04710 Circadian rhythm 13/646 43/7206 6.22001838377e-05 ko00950 Isoquinoline alkaloid biosynthesis 6/646 10/7206 7.77888203226e-05 ko00380 Tryptophan metabolism 14/646 50/7206 8.34555499052e-05 ko03010 Ribosome 1/646 129/7206 0.000128572429637 ko04146 Peroxisome 19/646 89/7206 0.000269449248279 ko05034 Alcoholism 7/646 238/7206 0.000299775765253 ko03040 Spliceosome 2/646 145/7206 0.000307731605332 ko04110 Cell cycle 2/646 145/7206 0.000307731605332 ko02010 ABC transporters 11/646 39/7206 0.000447258229081 ko00592 alpha-Linolenic acid metabolism 7/646 19/7206 0.000868848792683 ko00051 Fructose and mannose metabolism 11/646 42/7206 0.000890990654684 ko04621 NOD-like receptor signaling pathway 27/646 157/7206 0.000937140010681 ko04650 Natural killer cell mediated cytotoxicity 19/646 97/7206 0.0009431530347 ko03320 PPAR signaling pathway 15/646 69/7206 0.000954636681944 ko04390 Hippo signaling pathway 5/646 188/7206 0.00102762840053 ko04380 Osteoclast differentiation 24/646 134/7206 0.00104525761911 ko05321 Inflammatory bowel disease (IBD) 13/646 56/7206 0.00108022084961 ko04640 Hematopoietic cell lineage 14/646 64/7206 0.00131089869026 ko00960 Tropane, piperidine and pyridine alkaloid biosynthesis 3/646 4/7206 0.00267756776023 ko00140 Steroid hormone biosynthesis 10/646 41/7206 0.00270413628107 ko05224 Breast cancer 5/646 174/7206 0.00272847645495 ko04622 RIG-I-like receptor signaling pathway 13/646 62/7206 0.00287956268454 ko04064 NF-kappa B signaling pathway 18/646 96/7206 0.00312461837828 ko05140 Leishmaniasis 15/646 75/7206 0.00315785880876 ko04550 Signaling pathways regulating pluripotency of stem cells 5/646 165/7206 0.00360555801196 ko05340 Primary immunodeficiency 8/646 30/7206 0.00393931786629 ko04391 Hippo signaling pathway - fly 1/646 90/7206 0.00434922448273 ko04630 Jak-STAT signaling pathway 22/646 132/7206 0.00484515258994 ko05164 Influenza A 26/646 167/7206 0.00549082628851 ko00590 Arachidonic acid metabolism 11/646 52/7206 0.00551743127634 ko05144 Malaria 10/646 45/7206 0.00555258881925 ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis 3/646 5/7206 0.00624784829196 ko05133 Pertussis 16/646 87/7206 0.00669165928132 ko04723 Retrograde endocannabinoid signaling 6/646 175/7206 0.00681502746135 ko05323 Rheumatoid arthritis 16/646 89/7206 0.00734915477879 ko04975 Fat digestion and absorption 8/646 35/7206 0.0106329287114 ko00500 Starch and sucrose metabolism 8/646 35/7206 0.0106329287114 ko04062 Chemokine signaling pathway 29/646 201/7206 0.0114710061755 ko00362 Benzoate degradation 3/646 6/7206 0.0116669798309 ko04310 Wnt signaling pathway 7/646 181/7206 0.0117405730723 ko04620 Toll-like receptor signaling pathway 17/646 100/7206 0.0118548755722 ko05162 Measles 19/646 120/7206 0.0142104305943 ko04672 Intestinal immune network for IgA production 8/646 37/7206 0.0148837918432 ko04659 Th17 cell differentiation 17/646 106/7206 0.0156448961016 ko00071 Fatty acid degradation 9/646 45/7206 0.01665965371 ko04658 Th1 and Th2 cell differentiation 16/646 96/7206 0.017149170919 ko05134 Legionellosis 13/646 74/7206 0.0211521331663 ko01230 Biosynthesis of amino acids 14/646 85/7206 0.0211901003691 ko04120 Ubiquitin mediated proteolysis 5/646 138/7206 0.0231122842427 ko04111 Cell cycle - yeast 2/646 90/7206 0.0233449189028 ko04350 TGF-beta signaling pathway 3/646 103/7206 0.0236384085604 ko00052 Galactose metabolism 7/646 33/7206 0.024494382911 ko00561 Glycerolipid metabolism 11/646 63/7206 0.0255590489927 ko04151 PI3K-Akt signaling pathway 23/646 390/7206 0.0284006816471 ko00680 Methane metabolism 7/646 34/7206 0.0285422455352 ko05217 Basal cell carcinoma 1/646 68/7206 0.0292611535826 ko04974 Protein digestion and absorption 15/646 96/7206 0.0294589116078 ko05168 Herpes simplex infection 25/646 182/7206 0.0340130932419 ko00100 Steroid biosynthesis 5/646 21/7206 0.0346213408729 ko04662 B cell receptor signaling pathway 14/646 88/7206 0.0356138986596 ko05152 Tuberculosis 25/646 187/7206 0.0377666446249 ko04660 T cell receptor signaling pathway 18/646 124/7206 0.0378095106959 ko00010 Glycolysis / Gluconeogenesis 12/646 74/7206 0.0383665237282 ko05145 Toxoplasmosis 18/646 126/7206 0.0406790629638 ko04742 Taste transduction 1/646 61/7206 0.0406959762114 ko04540 Gap junction 5/646 128/7206 0.0415373864685 ko00965 Betalain biosynthesis 2/646 4/7206 0.0426048354451 ko00643 Styrene degradation 2/646 4/7206 0.0426048354451 ko00290 Valine, leucine and isoleucine biosynthesis 2/646 4/7206 0.0426048354451 ko00982 Drug metabolism - cytochrome P450 7/646 37/7206 0.0433219186401 ko04727 GABAergic synapse 4/646 110/7206 0.0438207495684 ko04270 Vascular smooth muscle contraction 21/646 154/7206 0.0457060439299 ko05200 Pathways in cancer 32/646 492/7206 0.0494508084049 ko04141 Protein processing in endoplasmic reticulum 9/646 184/7206 0.0494682114093 ko04728 Dopaminergic synapse 9/646 185/7206 0.0495883171489