ko pathway ratio_in_study ratio_in_pop p_value ko04724 Glutamatergic synapse 64/797 152/7206 2.80610994643e-23 ko04080 Neuroactive ligand-receptor interaction 118/797 423/7206 3.16981099689e-23 ko05032 Morphine addiction 48/797 110/7206 1.70147751177e-18 ko04727 GABAergic synapse 47/797 110/7206 1.1044797476e-17 ko05033 Nicotine addiction 32/797 56/7206 4.54438546297e-17 ko04728 Dopaminergic synapse 61/797 185/7206 4.95765481064e-16 ko04721 Synaptic vesicle cycle 37/797 80/7206 1.54523589208e-15 ko04725 Cholinergic synapse 55/797 160/7206 1.89335973994e-15 ko04713 Circadian entrainment 49/797 136/7206 8.2851627822e-15 ko04723 Retrograde endocannabinoid signaling 56/797 175/7206 3.5846986475e-14 ko04911 Insulin secretion 41/797 117/7206 3.90620506378e-12 ko04024 cAMP signaling pathway 70/797 279/7206 1.55355688201e-11 ko04726 Serotonergic synapse 43/797 137/7206 7.44745874674e-11 ko04921 Oxytocin signaling pathway 55/797 209/7206 3.58672455247e-10 ko04020 Calcium signaling pathway 64/797 265/7206 7.18622140549e-10 ko04261 Adrenergic signaling in cardiomyocytes 52/797 205/7206 4.97980139855e-09 ko05031 Amphetamine addiction 30/797 91/7206 1.61793368709e-08 ko04720 Long-term potentiation 29/797 99/7206 4.9862242609e-07 ko04966 Collecting duct acid secretion 13/797 26/7206 8.85837395339e-07 ko04970 Salivary secretion 27/797 95/7206 2.36043194191e-06 ko04514 Cell adhesion molecules (CAMs) 33/797 130/7206 3.19032288721e-06 ko05322 Systemic lupus erythematosus 2/797 151/7206 5.3345569044e-06 ko05030 Cocaine addiction 22/797 73/7206 7.15033237468e-06 ko04070 Phosphatidylinositol signaling system 29/797 112/7206 9.56798455479e-06 ko04925 Aldosterone synthesis and secretion 28/797 105/7206 1.01584036471e-05 ko03040 Spliceosome 2/797 145/7206 1.16937330506e-05 ko04971 Gastric acid secretion 26/797 98/7206 2.37437357709e-05 ko04072 Phospholipase D signaling pathway 42/797 197/7206 2.4147947718e-05 ko04120 Ubiquitin mediated proteolysis 2/797 138/7206 2.55538709248e-05 ko05110 Vibrio cholerae infection 19/797 63/7206 2.96076840667e-05 ko03013 RNA transport 4/797 166/7206 4.71222065375e-05 ko04010 MAPK signaling pathway 59/797 321/7206 7.70375862087e-05 ko04110 Cell cycle 3/797 145/7206 7.71315275537e-05 ko04972 Pancreatic secretion 27/797 111/7206 8.334051485e-05 ko04742 Taste transduction 17/797 61/7206 0.000226493839641 ko05164 Influenza A 5/797 167/7206 0.000234116439192 ko04750 Inflammatory mediator regulation of TRP channels 27/797 122/7206 0.000363002783616 ko05014 Amyotrophic lateral sclerosis (ALS) 19/797 74/7206 0.000481506220786 ko04745 Phototransduction - fly 12/797 38/7206 0.000545286483734 ko04022 cGMP-PKG signaling pathway 41/797 216/7206 0.00055053017865 ko05203 Viral carcinogenesis 14/797 277/7206 0.000572628960225 ko04964 Proximal tubule bicarbonate reclamation 10/797 29/7206 0.000725331486599 ko04730 Long-term depression 19/797 78/7206 0.000752357490493 ko05169 Epstein-Barr virus infection 9/797 206/7206 0.00096327809665 ko04744 Phototransduction 11/797 36/7206 0.00125489127074 ko05168 Herpes simplex infection 8/797 182/7206 0.0024841546873 ko04360 Axon guidance 41/797 233/7206 0.00271508060689 ko05162 Measles 4/797 120/7206 0.00314889728498 ko04510 Focal adhesion 13/797 240/7206 0.00317977739768 ko04922 Glucagon signaling pathway 25/797 128/7206 0.00406377918445 ko04141 Protein processing in endoplasmic reticulum 9/797 184/7206 0.00415862676947 ko04014 Ras signaling pathway 46/797 279/7206 0.00466565423473 ko04961 Endocrine and other factor-regulated calcium reabsorption 14/797 59/7206 0.00514817114296 ko00562 Inositol phosphate metabolism 19/797 89/7206 0.00545523380117 ko05120 Epithelial cell signaling in Helicobacter pylori infection 19/797 92/7206 0.0065299334938 ko04915 Estrogen signaling pathway 25/797 131/7206 0.00679817476072 ko05323 Rheumatoid arthritis 18/797 89/7206 0.00981277510573 ko04960 Aldosterone-regulated sodium reabsorption 10/797 41/7206 0.0119332995777 ko04260 Cardiac muscle contraction 19/797 98/7206 0.0137698850619 ko04621 NOD-like receptor signaling pathway 8/797 157/7206 0.0138172857798 ko00604 Glycosphingolipid biosynthesis - ganglio series 5/797 14/7206 0.0139402237799 ko04924 Renin secretion 17/797 86/7206 0.0146927131567 ko04930 Type II diabetes mellitus 12/797 54/7206 0.0149421735012 ko04612 Antigen processing and presentation 2/797 77/7206 0.0155294402974 ko04976 Bile secretion 16/797 80/7206 0.017885292881 ko05230 Central carbon metabolism in cancer 16/797 81/7206 0.0190307452311 ko04540 Gap junction 23/797 128/7206 0.021515717742 ko00310 Lysine degradation 2/797 73/7206 0.0219574552432 ko04710 Circadian rhythm 10/797 43/7206 0.0230473106217 ko04015 Rap1 signaling pathway 43/797 278/7206 0.0242607609292 ko05161 Hepatitis B 10/797 173/7206 0.0261795013966 ko00280 Valine, leucine and isoleucine degradation 1/797 54/7206 0.0267201641735 ko05016 Huntington's disease 14/797 215/7206 0.0272929799742 ko00520 Amino sugar and nucleotide sugar metabolism 1/797 55/7206 0.0274490382383 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 15/797 79/7206 0.0301679908658 ko00240 Pyrimidine metabolism 5/797 110/7206 0.0301885049429 ko04932 Non-alcoholic fatty liver disease (NAFLD) 11/797 182/7206 0.0302139270275 ko05217 Basal cell carcinoma 2/797 68/7206 0.0303222001504 ko05414 Dilated cardiomyopathy 20/797 112/7206 0.0316793298401 ko02010 ABC transporters 9/797 39/7206 0.0339337936382 ko04918 Thyroid hormone synthesis 16/797 86/7206 0.035695163283 ko00010 Glycolysis / Gluconeogenesis 14/797 74/7206 0.0389709797793 ko04350 TGF-beta signaling pathway 5/797 103/7206 0.0395103194769 ko04626 Plant-pathogen interaction 5/797 18/7206 0.0411445067661 ko04622 RIG-I-like receptor signaling pathway 2/797 62/7206 0.0424174277565 ko05130 Pathogenic Escherichia coli infection 3/797 77/7206 0.0430678014847 ko04550 Signaling pathways regulating pluripotency of stem cells 10/797 165/7206 0.0432176872453 ko04740 Olfactory transduction 15/797 80/7206 0.0454840903 ko00680 Methane metabolism 8/797 34/7206 0.047239467604