ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	162/966	423/7206	1.3808162809e-40
ko04724	Glutamatergic synapse	81/966	152/7206	2.3876807406e-32
ko05033	Nicotine addiction	46/966	56/7206	2.58452057662e-31
ko05032	Morphine addiction	61/966	110/7206	8.05845717806e-26
ko04727	GABAergic synapse	57/966	110/7206	3.17407693422e-22
ko04728	Dopaminergic synapse	77/966	185/7206	5.70277189654e-22
ko04713	Circadian entrainment	64/966	136/7206	7.01318051068e-22
ko04723	Retrograde endocannabinoid signaling	71/966	175/7206	1.4169936222e-19
ko04024	cAMP signaling pathway	90/966	279/7206	9.13604687561e-17
ko04020	Calcium signaling pathway	86/966	265/7206	3.15806966403e-16
ko04725	Cholinergic synapse	62/966	160/7206	4.46355693871e-16
ko04721	Synaptic vesicle cycle	40/966	80/7206	2.9603337822e-15
ko04726	Serotonergic synapse	55/966	137/7206	3.56047522927e-15
ko04744	Phototransduction	25/966	36/7206	1.58417134787e-14
ko04911	Insulin secretion	47/966	117/7206	3.69850612082e-13
ko04742	Taste transduction	31/966	61/7206	2.35309102885e-12
ko04720	Long-term potentiation	41/966	99/7206	3.72527940207e-12
ko04921	Oxytocin signaling pathway	65/966	209/7206	1.51672015477e-11
ko05031	Amphetamine addiction	37/966	91/7206	8.136160433e-11
ko04261	Adrenergic signaling in cardiomyocytes	59/966	205/7206	4.09963479935e-09
ko05030	Cocaine addiction	27/966	73/7206	3.04259849954e-07
ko03040	Spliceosome	2/966	145/7206	3.87934956751e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	27/966	74/7206	4.1890807113e-07
ko05203	Viral carcinogenesis	12/966	277/7206	5.34710720646e-07
ko04925	Aldosterone synthesis and secretion	34/966	105/7206	6.2374393309e-07
ko04740	Olfactory transduction	28/966	80/7206	6.90451561812e-07
ko04970	Salivary secretion	31/966	95/7206	1.02822681698e-06
ko04745	Phototransduction - fly	17/966	38/7206	2.28970121354e-06
ko04971	Gastric acid secretion	30/966	98/7206	7.37619749012e-06
ko04060	Cytokine-cytokine receptor interaction	7/966	191/7206	7.50595651903e-06
ko04070	Phosphatidylinositol signaling system	33/966	112/7206	7.53789445103e-06
ko04730	Long-term depression	25/966	78/7206	1.61284056924e-05
ko05168	Herpes simplex infection	7/966	182/7206	2.14267726106e-05
ko05164	Influenza A	6/966	167/7206	2.68640089956e-05
ko04022	cGMP-PKG signaling pathway	51/966	216/7206	3.95330464711e-05
ko05322	Systemic lupus erythematosus	5/966	151/7206	4.92595822021e-05
ko04010	MAPK signaling pathway	69/966	321/7206	4.96521188213e-05
ko04972	Pancreatic secretion	31/966	111/7206	5.3451837908e-05
ko04514	Cell adhesion molecules (CAMs)	34/966	130/7206	7.79801522409e-05
ko04110	Cell cycle	5/966	145/7206	0.000101265053576
ko03013	RNA transport	7/966	166/7206	0.000117510156028
ko04750	Inflammatory mediator regulation of TRP channels	32/966	122/7206	0.000131109431002
ko04072	Phospholipase D signaling pathway	45/966	197/7206	0.000265634387672
ko04612	Antigen processing and presentation	1/966	77/7206	0.000307881203179
ko04621	NOD-like receptor signaling pathway	7/966	157/7206	0.000320821097737
ko05140	Leishmaniasis	1/966	75/7206	0.000469213447364
ko05169	Epstein-Barr virus infection	12/966	206/7206	0.000561544638917
ko04360	Axon guidance	50/966	233/7206	0.000567028936446
ko04141	Protein processing in endoplasmic reticulum	10/966	184/7206	0.000606674603257
ko05161	Hepatitis B	9/966	173/7206	0.000620456394284
ko04964	Proximal tubule bicarbonate reclamation	11/966	29/7206	0.000816936551064
ko04064	NF-kappa B signaling pathway	3/966	96/7206	0.00126258040527
ko04626	Plant-pathogen interaction	8/966	18/7206	0.00127617575614
ko04260	Cardiac muscle contraction	25/966	98/7206	0.00138467993457
ko04924	Renin secretion	22/966	86/7206	0.00212185139502
ko04120	Ubiquitin mediated proteolysis	7/966	138/7206	0.00221362347768
ko04610	Complement and coagulation cascades	2/966	79/7206	0.00224554230971
ko03008	Ribosome biogenesis in eukaryotes	2/966	79/7206	0.00224554230971
ko04540	Gap junction	30/966	128/7206	0.00228106397595
ko04915	Estrogen signaling pathway	30/966	131/7206	0.00264231276498
ko04014	Ras signaling pathway	55/966	279/7206	0.00293976667643
ko04630	Jak-STAT signaling pathway	7/966	132/7206	0.00414724455421
ko05162	Measles	6/966	120/7206	0.00416592338496
ko05166	HTLV-I infection	24/966	292/7206	0.00642318387475
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	19/966	79/7206	0.0113243486064
ko00590	Arachidonic acid metabolism	1/966	52/7206	0.0119829016941
ko05200	Pathways in cancer	48/966	492/7206	0.0134313859313
ko04930	Type II diabetes mellitus	14/966	54/7206	0.0138061530458
ko03420	Nucleotide excision repair	1/966	46/7206	0.0165900559826
ko04966	Collecting duct acid secretion	8/966	26/7206	0.0170819152803
ko00562	Inositol phosphate metabolism	20/966	89/7206	0.0177050001398
ko05214	Glioma	18/966	79/7206	0.0193999561401
ko03320	PPAR signaling pathway	3/966	69/7206	0.0206729417593
ko04012	ErbB signaling pathway	23/966	109/7206	0.0228633100596
ko04114	Oocyte meiosis	28/966	139/7206	0.023283080045
ko03022	Basal transcription factors	1/966	44/7206	0.0245743956393
ko00071	Fatty acid degradation	1/966	45/7206	0.0251662747746
ko04922	Glucagon signaling pathway	26/966	128/7206	0.0256863197353
ko05010	Alzheimer's disease	38/966	202/7206	0.0273800582245
ko04146	Peroxisome	5/966	89/7206	0.0275338145061
ko00480	Glutathione metabolism	2/966	55/7206	0.0279163832013
ko05130	Pathogenic Escherichia coli infection	4/966	77/7206	0.0286330690482
ko05217	Basal cell carcinoma	3/966	68/7206	0.0296758592775
ko00604	Glycosphingolipid biosynthesis - ganglio series	5/966	14/7206	0.0302229928576
ko00240	Pyrimidine metabolism	7/966	110/7206	0.0328668453369
ko04722	Neurotrophin signaling pathway	31/966	160/7206	0.0336943919232
ko04658	Th1 and Th2 cell differentiation	6/966	96/7206	0.0346697775636
ko05414	Dilated cardiomyopathy	23/966	112/7206	0.0347115421901
ko00980	Metabolism of xenobiotics by cytochrome P450	1/966	40/7206	0.0360711925411
ko04932	Non-alcoholic fatty liver disease (NAFLD)	15/966	182/7206	0.0362428497794
ko04657	IL-17 signaling pathway	5/966	87/7206	0.0377899244927
ko05133	Pertussis	5/966	87/7206	0.0377899244927
ko04710	Circadian rhythm	11/966	43/7206	0.0387678531882
ko00533	Glycosaminoglycan biosynthesis - keratan sulfate	5/966	15/7206	0.0404664806661
ko04640	Hematopoietic cell lineage	3/966	64/7206	0.0407507471417
ko05034	Alcoholism	43/966	238/7206	0.0414510410281
ko00280	Valine, leucine and isoleucine degradation	2/966	54/7206	0.0415380810747
ko04371	Apelin signaling pathway	33/966	177/7206	0.043996083097
ko04912	GnRH signaling pathway	24/966	122/7206	0.0446514416496
ko05205	Proteoglycans in cancer	25/966	271/7206	0.0449216008418
ko04976	Bile secretion	17/966	80/7206	0.0466404076616
ko05230	Central carbon metabolism in cancer	17/966	81/7206	0.049315126646