ko pathway ratio_in_study ratio_in_pop p_value ko04080 Neuroactive ligand-receptor interaction 149/770 423/7206 9.95478387852e-45 ko04724 Glutamatergic synapse 79/770 152/7206 9.36851976039e-38 ko05033 Nicotine addiction 47/770 56/7206 1.85634674305e-37 ko04727 GABAergic synapse 58/770 110/7206 2.52909085122e-28 ko05032 Morphine addiction 57/770 110/7206 2.48843625548e-27 ko04713 Circadian entrainment 62/770 136/7206 1.09070581857e-25 ko04728 Dopaminergic synapse 72/770 185/7206 1.60230088294e-24 ko04723 Retrograde endocannabinoid signaling 67/770 175/7206 2.12828259583e-22 ko04024 cAMP signaling pathway 82/770 279/7206 1.07791095967e-18 ko04725 Cholinergic synapse 55/770 160/7206 4.09890733407e-16 ko04721 Synaptic vesicle cycle 36/770 80/7206 3.68385519744e-15 ko04911 Insulin secretion 44/770 117/7206 9.67331551152e-15 ko05031 Amphetamine addiction 37/770 91/7206 7.76439937879e-14 ko05030 Cocaine addiction 32/770 73/7206 3.17231687702e-13 ko04726 Serotonergic synapse 45/770 137/7206 1.35324471203e-12 ko04720 Long-term potentiation 37/770 99/7206 1.6952677903e-12 ko04020 Calcium signaling pathway 66/770 265/7206 1.7914877194e-11 ko04261 Adrenergic signaling in cardiomyocytes 55/770 205/7206 4.03479255318e-11 ko04742 Taste transduction 26/770 61/7206 1.17950584012e-10 ko04921 Oxytocin signaling pathway 54/770 209/7206 3.24675705067e-10 ko04970 Salivary secretion 31/770 95/7206 5.34771482477e-09 ko04971 Gastric acid secretion 31/770 98/7206 1.23874823498e-08 ko05014 Amyotrophic lateral sclerosis (ALS) 26/770 74/7206 1.63599718764e-08 ko04060 Cytokine-cytokine receptor interaction 2/770 191/7206 1.58388867584e-07 ko04010 MAPK signaling pathway 65/770 321/7206 2.37465940366e-07 ko04925 Aldosterone synthesis and secretion 29/770 105/7206 9.36494909961e-07 ko04972 Pancreatic secretion 30/770 111/7206 1.00869467446e-06 ko04744 Phototransduction 15/770 36/7206 1.52290533155e-06 ko04072 Phospholipase D signaling pathway 43/770 197/7206 3.4561999006e-06 ko04514 Cell adhesion molecules (CAMs) 32/770 130/7206 4.4366631483e-06 ko04915 Estrogen signaling pathway 32/770 131/7206 5.17720402679e-06 ko05203 Viral carcinogenesis 9/770 277/7206 5.97161545461e-06 ko04740 Olfactory transduction 23/770 80/7206 5.97644724625e-06 ko04730 Long-term depression 22/770 78/7206 1.33216650131e-05 ko03040 Spliceosome 2/770 145/7206 1.77294142607e-05 ko05034 Alcoholism 47/770 238/7206 2.45171975766e-05 ko05168 Herpes simplex infection 4/770 182/7206 2.46540965038e-05 ko04022 cGMP-PKG signaling pathway 43/770 216/7206 4.45826386979e-05 ko05164 Influenza A 4/770 167/7206 6.96069284469e-05 ko04360 Axon guidance 45/770 233/7206 8.27213582668e-05 ko04350 TGF-beta signaling pathway 1/770 103/7206 0.000167791939046 ko04621 NOD-like receptor signaling pathway 4/770 157/7206 0.000203520067742 ko04540 Gap junction 28/770 128/7206 0.000217022763343 ko05414 Dilated cardiomyopathy 25/770 112/7206 0.000288455737105 ko05322 Systemic lupus erythematosus 4/770 151/7206 0.000426416585891 ko04912 GnRH signaling pathway 26/770 122/7206 0.000519460265846 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 19/770 79/7206 0.000627343300049 ko04260 Cardiac muscle contraction 22/770 98/7206 0.000709661737307 ko04371 Apelin signaling pathway 34/770 177/7206 0.000739364939693 ko04120 Ubiquitin mediated proteolysis 4/770 138/7206 0.00116926688746 ko04014 Ras signaling pathway 47/770 279/7206 0.0014423863936 ko04745 Phototransduction - fly 11/770 38/7206 0.0015436279314 ko05169 Epstein-Barr virus infection 9/770 206/7206 0.00180293677844 ko04924 Renin secretion 19/770 86/7206 0.00215553546588 ko00512 Mucin type O-glycan biosynthesis 9/770 29/7206 0.00241040917565 ko04612 Antigen processing and presentation 1/770 77/7206 0.00263513745942 ko00240 Pyrimidine metabolism 3/770 110/7206 0.0029017119263 ko04932 Non-alcoholic fatty liver disease (NAFLD) 8/770 182/7206 0.00329902618986 ko04015 Rap1 signaling pathway 45/770 278/7206 0.00393371417289 ko05231 Choline metabolism in cancer 25/770 134/7206 0.00455316998207 ko03013 RNA transport 7/770 166/7206 0.00470191882877 ko04146 Peroxisome 2/770 89/7206 0.00508451023004 ko04976 Bile secretion 17/770 80/7206 0.00523038037036 ko04214 Apoptosis - fly 1/770 72/7206 0.00597661703267 ko04110 Cell cycle 6/770 145/7206 0.00633403393007 ko05162 Measles 4/770 120/7206 0.00649238787155 ko04062 Chemokine signaling pathway 34/770 201/7206 0.00722606084549 ko03018 RNA degradation 2/770 84/7206 0.00727576392454 ko04141 Protein processing in endoplasmic reticulum 9/770 184/7206 0.00744427337668 ko04923 Regulation of lipolysis in adipocytes 16/770 77/7206 0.00814741373795 ko04070 Phosphatidylinositol signaling system 21/770 112/7206 0.00852343994698 ko05205 Proteoglycans in cancer 16/770 271/7206 0.00875957545032 ko04626 Plant-pathogen interaction 6/770 18/7206 0.00876864749426 ko04961 Endocrine and other factor-regulated calcium reabsorption 13/770 59/7206 0.00945059156029 ko00513 Various types of N-glycan biosynthesis 10/770 42/7206 0.011245664103 ko04750 Inflammatory mediator regulation of TRP channels 22/770 122/7206 0.0117320572168 ko00604 Glycosphingolipid biosynthesis - ganglio series 5/770 14/7206 0.0120868198372 ko03008 Ribosome biogenesis in eukaryotes 2/770 79/7206 0.0154123881732 ko00330 Arginine and proline metabolism 1/770 61/7206 0.0191516698914 ko04916 Melanogenesis 24/770 142/7206 0.0196044170281 ko00310 Lysine degradation 2/770 73/7206 0.0212734811727 ko05410 Hypertrophic cardiomyopathy (HCM) 18/770 100/7206 0.022305513001 ko04217 Necroptosis 10/770 178/7206 0.0261733318154 ko00480 Glutathione metabolism 1/770 55/7206 0.0266686173034 ko05321 Inflammatory bowel disease (IBD) 1/770 56/7206 0.0270792038525 ko04722 Neurotrophin signaling pathway 26/770 160/7206 0.0271517068693 ko04140 Autophagy - animal 9/770 164/7206 0.0288251277869 ko04964 Proximal tubule bicarbonate reclamation 7/770 29/7206 0.0296445216203 ko05202 Transcriptional misregulation in cancer 11/770 188/7206 0.0303911723088 ko05146 Amoebiasis 4/770 99/7206 0.0313929293018 ko04142 Lysosome 8/770 151/7206 0.0319020455058 ko05161 Hepatitis B 10/770 173/7206 0.0335398710182 ko04071 Sphingolipid signaling pathway 26/770 162/7206 0.0381598539028 ko04973 Carbohydrate digestion and absorption 9/770 42/7206 0.0390694584489 ko04930 Type II diabetes mellitus 11/770 54/7206 0.0417794271799 ko04064 NF-kappa B signaling pathway 4/770 96/7206 0.0434483812957 ko00515 Mannose type O-glycan biosynthesis 6/770 25/7206 0.04394462968