ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04724	Glutamatergic synapse	78/781	152/7206	2.60984816815e-36
ko05033	Nicotine addiction	44/781	56/7206	1.79118920509e-32
ko04080	Neuroactive ligand-receptor interaction	130/781	423/7206	4.2786530242e-31
ko05032	Morphine addiction	58/781	110/7206	5.44633106155e-28
ko04727	GABAergic synapse	57/781	110/7206	5.26867434239e-27
ko04713	Circadian entrainment	59/781	136/7206	8.62666059401e-23
ko04723	Retrograde endocannabinoid signaling	67/781	175/7206	4.78742054886e-22
ko04728	Dopaminergic synapse	65/781	185/7206	4.22609319953e-19
ko04725	Cholinergic synapse	59/781	160/7206	1.35733955176e-18
ko04024	cAMP signaling pathway	79/781	279/7206	1.27003204818e-16
ko04721	Synaptic vesicle cycle	35/781	80/7206	3.98514822549e-14
ko04911	Insulin secretion	43/781	117/7206	8.40234484141e-14
ko04020	Calcium signaling pathway	69/781	265/7206	1.13430579191e-12
ko04921	Oxytocin signaling pathway	58/781	209/7206	4.55415655006e-12
ko04726	Serotonergic synapse	44/781	137/7206	9.40630712967e-12
ko04261	Adrenergic signaling in cardiomyocytes	56/781	205/7206	2.15682500619e-11
ko04742	Taste transduction	27/781	61/7206	2.45383063391e-11
ko04720	Long-term potentiation	35/781	99/7206	6.43709451817e-11
ko05031	Amphetamine addiction	33/781	91/7206	1.04463339016e-10
ko04072	Phospholipase D signaling pathway	51/781	197/7206	1.50969457848e-09
ko05030	Cocaine addiction	27/781	73/7206	3.22533675114e-09
ko04010	MAPK signaling pathway	70/781	321/7206	5.93059726599e-09
ko04744	Phototransduction	17/781	36/7206	3.8892317114e-08
ko04925	Aldosterone synthesis and secretion	31/781	105/7206	1.0413941718e-07
ko04970	Salivary secretion	29/781	95/7206	1.20748475503e-07
ko05203	Viral carcinogenesis	8/781	277/7206	9.46818698781e-07
ko04972	Pancreatic secretion	30/781	111/7206	1.36324005208e-06
ko03040	Spliceosome	1/781	145/7206	2.1045222605e-06
ko04022	cGMP-PKG signaling pathway	45/781	216/7206	1.13490597954e-05
ko04070	Phosphatidylinositol signaling system	28/781	112/7206	1.78539418966e-05
ko04110	Cell cycle	2/781	145/7206	1.78771778534e-05
ko04514	Cell adhesion molecules (CAMs)	31/781	130/7206	2.03252440616e-05
ko04915	Estrogen signaling pathway	31/781	131/7206	2.25437760198e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	21/781	74/7206	2.33905086883e-05
ko04060	Cytokine-cytokine receptor interaction	5/781	191/7206	2.84659851806e-05
ko04260	Cardiac muscle contraction	25/781	98/7206	4.24794553544e-05
ko05414	Dilated cardiomyopathy	27/781	112/7206	4.63300753792e-05
ko04730	Long-term depression	21/781	78/7206	5.54174194865e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	21/781	79/7206	6.79392256132e-05
ko05168	Herpes simplex infection	5/781	182/7206	8.4308103785e-05
ko04971	Gastric acid secretion	24/781	98/7206	0.000100523265478
ko04350	TGF-beta signaling pathway	1/781	103/7206	0.000166908282748
ko04360	Axon guidance	44/781	233/7206	0.000226387459648
ko05164	Influenza A	5/781	167/7206	0.00033820456548
ko03013	RNA transport	6/781	166/7206	0.000948636186081
ko04961	Endocrine and other factor-regulated calcium reabsorption	15/781	59/7206	0.00120302321666
ko05322	Systemic lupus erythematosus	5/781	151/7206	0.00127979365231
ko05169	Epstein-Barr virus infection	9/781	206/7206	0.00131066823994
ko04930	Type II diabetes mellitus	14/781	54/7206	0.00141572662971
ko04745	Phototransduction - fly	11/781	38/7206	0.00173373998856
ko04014	Ras signaling pathway	47/781	279/7206	0.00215816969446
ko05205	Proteoglycans in cancer	15/781	271/7206	0.00269434253391
ko04740	Olfactory transduction	18/781	80/7206	0.00293929320693
ko04750	Inflammatory mediator regulation of TRP channels	24/781	122/7206	0.0031031723042
ko04540	Gap junction	25/781	128/7206	0.00356882950395
ko05410	Hypertrophic cardiomyopathy (HCM)	20/781	100/7206	0.00554520873374
ko04141	Protein processing in endoplasmic reticulum	9/781	184/7206	0.00557317988459
ko04015	Rap1 signaling pathway	45/781	278/7206	0.0056028768555
ko04371	Apelin signaling pathway	31/781	177/7206	0.00662242111884
ko05231	Choline metabolism in cancer	25/781	134/7206	0.00693485768361
ko05034	Alcoholism	39/781	238/7206	0.00772656446823
ko04923	Regulation of lipolysis in adipocytes	16/781	77/7206	0.00890536671089
ko04964	Proximal tubule bicarbonate reclamation	8/781	29/7206	0.00991730272138
ko03008	Ribosome biogenesis in eukaryotes	2/781	79/7206	0.0103719600778
ko04550	Signaling pathways regulating pluripotency of stem cells	8/781	165/7206	0.0105986302649
ko00604	Glycosphingolipid biosynthesis - ganglio series	5/781	14/7206	0.0128195035334
ko04924	Renin secretion	17/781	86/7206	0.0131229704651
ko04918	Thyroid hormone synthesis	17/781	86/7206	0.0131229704651
ko05140	Leishmaniasis	2/781	75/7206	0.0148432581816
ko04976	Bile secretion	16/781	80/7206	0.0165508302945
ko05162	Measles	5/781	120/7206	0.0165654740213
ko04621	NOD-like receptor signaling pathway	8/781	157/7206	0.0185127505069
ko04071	Sphingolipid signaling pathway	27/781	162/7206	0.0208558356915
ko00310	Lysine degradation	2/781	73/7206	0.0213868629574
ko00562	Inositol phosphate metabolism	17/781	89/7206	0.0235386724153
ko04144	Endocytosis	50/781	342/7206	0.0255650699663
ko04120	Ubiquitin mediated proteolysis	7/781	138/7206	0.0260521568896
ko00480	Glutathione metabolism	1/781	55/7206	0.0268417809539
ko05321	Inflammatory bowel disease (IBD)	1/781	56/7206	0.0275204734198
ko00240	Pyrimidine metabolism	5/781	110/7206	0.029601115004
ko04150	mTOR signaling pathway	11/781	184/7206	0.0300666554422
ko05217	Basal cell carcinoma	2/781	68/7206	0.0300889507844
ko03320	PPAR signaling pathway	2/781	69/7206	0.0303354437261
ko04064	NF-kappa B signaling pathway	4/781	96/7206	0.0308069986375
ko05131	Shigellosis	3/781	82/7206	0.0311775136805
ko00512	Mucin type O-glycan biosynthesis	7/781	29/7206	0.0317513275288
ko04932	Non-alcoholic fatty liver disease (NAFLD)	11/781	182/7206	0.0388963668056
ko00513	Various types of N-glycan biosynthesis	9/781	42/7206	0.0410306431407
ko04973	Carbohydrate digestion and absorption	9/781	42/7206	0.0410306431407
ko05110	Vibrio cholerae infection	12/781	63/7206	0.0420047751342
ko04640	Hematopoietic cell lineage	2/781	64/7206	0.0426143998126
ko00515	Mannose type O-glycan biosynthesis	6/781	25/7206	0.0466290854098