ko pathway ratio_in_study ratio_in_pop p_value ko04724 Glutamatergic synapse 37/377 152/7206 9.43628832677e-16 ko04728 Dopaminergic synapse 36/377 185/7206 3.43116367928e-12 ko04721 Synaptic vesicle cycle 23/377 80/7206 7.62355804551e-12 ko04911 Insulin secretion 25/377 117/7206 1.02490332043e-09 ko04713 Circadian entrainment 27/377 136/7206 1.23029872517e-09 ko04727 GABAergic synapse 24/377 110/7206 1.42751606521e-09 ko05033 Nicotine addiction 17/377 56/7206 1.72713213739e-09 ko04725 Cholinergic synapse 25/377 160/7206 6.98860102302e-07 ko04261 Adrenergic signaling in cardiomyocytes 29/377 205/7206 7.67679991265e-07 ko04723 Retrograde endocannabinoid signaling 26/377 175/7206 1.1308108119e-06 ko04360 Axon guidance 31/377 233/7206 1.23522364402e-06 ko04720 Long-term potentiation 18/377 99/7206 2.90424060714e-06 ko04514 Cell adhesion molecules (CAMs) 21/377 130/7206 3.20421480258e-06 ko05032 Morphine addiction 19/377 110/7206 3.42305393577e-06 ko05031 Amphetamine addiction 17/377 91/7206 3.73308531657e-06 ko04024 cAMP signaling pathway 33/377 279/7206 1.15936648425e-05 ko04970 Salivary secretion 16/377 95/7206 2.82483671626e-05 ko04726 Serotonergic synapse 19/377 137/7206 8.4597332903e-05 ko05014 Amyotrophic lateral sclerosis (ALS) 13/377 74/7206 0.000101666518385 ko04080 Neuroactive ligand-receptor interaction 40/377 423/7206 0.000260835777129 ko04966 Collecting duct acid secretion 7/377 26/7206 0.00028066297063 ko04020 Calcium signaling pathway 28/377 265/7206 0.000341752978073 ko05030 Cocaine addiction 12/377 73/7206 0.000357079665525 ko05110 Vibrio cholerae infection 11/377 63/7206 0.00036542098169 ko04971 Gastric acid secretion 14/377 98/7206 0.000529251872795 ko04964 Proximal tubule bicarbonate reclamation 7/377 29/7206 0.000581203053255 ko04745 Phototransduction - fly 8/377 38/7206 0.000637937058068 ko04730 Long-term depression 12/377 78/7206 0.000666054476707 ko04022 cGMP-PKG signaling pathway 23/377 216/7206 0.00096677917019 ko05010 Alzheimer's disease 22/377 202/7206 0.00103148425051 ko04960 Aldosterone-regulated sodium reabsorption 8/377 41/7206 0.00108632634002 ko04973 Carbohydrate digestion and absorption 8/377 42/7206 0.00128190959883 ko04921 Oxytocin signaling pathway 22/377 209/7206 0.00144266328536 ko04930 Type II diabetes mellitus 9/377 54/7206 0.00174568202402 ko04972 Pancreatic secretion 14/377 111/7206 0.00183865286577 ko05120 Epithelial cell signaling in Helicobacter pylori infection 12/377 92/7206 0.00287840622762 ko04961 Endocrine and other factor-regulated calcium reabsorption 9/377 59/7206 0.00327622969692 ko04010 MAPK signaling pathway 29/377 321/7206 0.00429107469634 ko04060 Cytokine-cytokine receptor interaction 2/377 191/7206 0.00439090592315 ko05322 Systemic lupus erythematosus 1/377 151/7206 0.00482269075528 ko04260 Cardiac muscle contraction 12/377 98/7206 0.00486372382333 ko05168 Herpes simplex infection 2/377 182/7206 0.00618502242995 ko04925 Aldosterone synthesis and secretion 12/377 105/7206 0.0118207854665 ko04071 Sphingolipid signaling pathway 16/377 162/7206 0.0119475168171 ko03013 RNA transport 2/377 166/7206 0.0124048720834 ko04626 Plant-pathogen interaction 4/377 18/7206 0.0125734459747 ko04070 Phosphatidylinositol signaling system 12/377 112/7206 0.0160726685366 ko04978 Mineral absorption 6/377 40/7206 0.0167171557018 ko04014 Ras signaling pathway 23/377 279/7206 0.0274693099636 ko04145 Phagosome 15/377 162/7206 0.0298419764901 ko00240 Pyrimidine metabolism 1/377 110/7206 0.030571585304 ko00604 Glycosphingolipid biosynthesis - ganglio series 3/377 14/7206 0.0336190774606 ko04114 Oocyte meiosis 13/377 139/7206 0.0342732074219 ko04750 Inflammatory mediator regulation of TRP channels 12/377 122/7206 0.0359545274153 ko04740 Olfactory transduction 9/377 80/7206 0.0364253887511 ko02024 Quorum sensing 3/377 15/7206 0.0404362786112 ko04924 Renin secretion 9/377 86/7206 0.0445900736373 ko05152 Tuberculosis 16/377 187/7206 0.0452509999339 ko05142 Chagas disease (American trypanosomiasis) 12/377 130/7206 0.0461781498735 ko04390 Hippo signaling pathway 16/377 188/7206 0.0463750182897 ko04072 Phospholipase D signaling pathway 17/377 197/7206 0.0487347662779 ko04120 Ubiquitin mediated proteolysis 2/377 138/7206 0.0497449188529