ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	195/1239	423/7206	1.81096720855e-46
ko04724	Glutamatergic synapse	88/1239	152/7206	2.85204013587e-30
ko05033	Nicotine addiction	48/1239	56/7206	3.16113239905e-29
ko05032	Morphine addiction	69/1239	110/7206	6.97003339216e-27
ko04713	Circadian entrainment	78/1239	136/7206	1.49019719683e-26
ko04728	Dopaminergic synapse	90/1239	185/7206	1.57233359749e-23
ko04727	GABAergic synapse	64/1239	110/7206	1.93098852736e-22
ko04725	Cholinergic synapse	78/1239	160/7206	1.36744061295e-20
ko04721	Synaptic vesicle cycle	50/1239	80/7206	1.08878203743e-19
ko04024	cAMP signaling pathway	108/1239	279/7206	2.36458360284e-18
ko04723	Retrograde endocannabinoid signaling	78/1239	175/7206	1.13253070737e-17
ko04020	Calcium signaling pathway	99/1239	265/7206	1.40078863676e-15
ko04911	Insulin secretion	57/1239	117/7206	2.42439415252e-15
ko04742	Taste transduction	38/1239	61/7206	3.40429257071e-15
ko04921	Oxytocin signaling pathway	80/1239	209/7206	2.07440096789e-13
ko04726	Serotonergic synapse	59/1239	137/7206	7.34017132537e-13
ko04360	Axon guidance	84/1239	233/7206	2.51834190412e-12
ko03040	Spliceosome	1/1239	145/7206	4.41089804463e-11
ko04261	Adrenergic signaling in cardiomyocytes	74/1239	205/7206	4.70781393951e-11
ko04744	Phototransduction	24/1239	36/7206	5.53746083727e-11
ko05031	Amphetamine addiction	42/1239	91/7206	1.09391989326e-10
ko04720	Long-term potentiation	43/1239	99/7206	7.21107543079e-10
ko04970	Salivary secretion	41/1239	95/7206	2.27105858487e-09
ko04925	Aldosterone synthesis and secretion	43/1239	105/7206	8.60727537203e-09
ko03013	RNA transport	5/1239	166/7206	1.53942197634e-08
ko05030	Cocaine addiction	32/1239	73/7206	8.4378668944e-08
ko04740	Olfactory transduction	34/1239	80/7206	8.45855372521e-08
ko04022	cGMP-PKG signaling pathway	68/1239	216/7206	1.85782228831e-07
ko05203	Viral carcinogenesis	19/1239	277/7206	5.34536229281e-07
ko05168	Herpes simplex infection	9/1239	182/7206	7.41135719778e-07
ko04060	Cytokine-cytokine receptor interaction	10/1239	191/7206	8.19463201484e-07
ko04971	Gastric acid secretion	37/1239	98/7206	1.02140092456e-06
ko04010	MAPK signaling pathway	89/1239	321/7206	1.50787838498e-06
ko04610	Complement and coagulation cascades	1/1239	79/7206	7.93684220624e-06
ko03008	Ribosome biogenesis in eukaryotes	1/1239	79/7206	7.93684220624e-06
ko04141	Protein processing in endoplasmic reticulum	11/1239	184/7206	9.95770427053e-06
ko05322	Systemic lupus erythematosus	8/1239	151/7206	1.62558999461e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1239	74/7206	1.80119047289e-05
ko05164	Influenza A	10/1239	167/7206	2.57969576683e-05
ko04540	Gap junction	41/1239	128/7206	4.226909086e-05
ko04514	Cell adhesion molecules (CAMs)	41/1239	130/7206	5.13686334907e-05
ko04014	Ras signaling pathway	74/1239	279/7206	6.57433281629e-05
ko04972	Pancreatic secretion	36/1239	111/7206	6.95463830111e-05
ko04120	Ubiquitin mediated proteolysis	8/1239	138/7206	9.10555442473e-05
ko04621	NOD-like receptor signaling pathway	10/1239	157/7206	9.6760988388e-05
ko04640	Hematopoietic cell lineage	1/1239	64/7206	0.000157939326787
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1239	79/7206	0.00023279131669
ko04924	Renin secretion	29/1239	86/7206	0.000233825987175
ko04745	Phototransduction - fly	16/1239	38/7206	0.000265015979207
ko04371	Apelin signaling pathway	49/1239	177/7206	0.000384968485799
ko04730	Long-term depression	26/1239	78/7206	0.000436303068507
ko04072	Phospholipase D signaling pathway	53/1239	197/7206	0.00052183004847
ko04070	Phosphatidylinositol signaling system	34/1239	112/7206	0.00055048515323
ko04612	Antigen processing and presentation	3/1239	77/7206	0.000673912719453
ko04961	Endocrine and other factor-regulated calcium reabsorption	21/1239	59/7206	0.000693212140348
ko00604	Glycosphingolipid biosynthesis - ganglio series	8/1239	14/7206	0.000842016199417
ko04260	Cardiac muscle contraction	30/1239	98/7206	0.00102687614247
ko00590	Arachidonic acid metabolism	1/1239	52/7206	0.0012654827827
ko00240	Pyrimidine metabolism	7/1239	110/7206	0.00129028415892
ko05169	Epstein-Barr virus infection	19/1239	206/7206	0.00136757856634
ko05414	Dilated cardiomyopathy	33/1239	112/7206	0.00138569319193
ko04750	Inflammatory mediator regulation of TRP channels	35/1239	122/7206	0.00147893363245
ko04146	Peroxisome	5/1239	89/7206	0.00172030597745
ko05205	Proteoglycans in cancer	28/1239	271/7206	0.00173621815939
ko00330	Arginine and proline metabolism	2/1239	61/7206	0.00173803129604
ko00260	Glycine, serine and threonine metabolism	1/1239	48/7206	0.00186163266977
ko03320	PPAR signaling pathway	3/1239	69/7206	0.00206189370007
ko04966	Collecting duct acid secretion	11/1239	26/7206	0.00231153197729
ko04976	Bile secretion	25/1239	80/7206	0.00243208859907
ko04064	NF-kappa B signaling pathway	6/1239	96/7206	0.00247791653
ko04110	Cell cycle	12/1239	145/7206	0.00256395214292
ko03420	Nucleotide excision repair	1/1239	46/7206	0.00280195496871
ko04711	Circadian rhythm - fly	7/1239	13/7206	0.00286119194029
ko05162	Measles	9/1239	120/7206	0.00314170799496
ko04915	Estrogen signaling pathway	36/1239	131/7206	0.00319377521853
ko05140	Leishmaniasis	4/1239	75/7206	0.00327582699652
ko03018	RNA degradation	5/1239	84/7206	0.00340923183285
ko00480	Glutathione metabolism	2/1239	55/7206	0.00371408658228
ko05110	Vibrio cholerae infection	20/1239	63/7206	0.00399280622315
ko03022	Basal transcription factors	1/1239	44/7206	0.0042419547154
ko00071	Fatty acid degradation	1/1239	45/7206	0.00440657860468
ko04916	Melanogenesis	38/1239	142/7206	0.00463667332821
ko05131	Shigellosis	5/1239	82/7206	0.00477877681916
ko04630	Jak-STAT signaling pathway	11/1239	132/7206	0.00491384382183
ko00280	Valine, leucine and isoleucine degradation	2/1239	54/7206	0.00561503622955
ko04923	Regulation of lipolysis in adipocytes	23/1239	77/7206	0.00565844848949
ko04622	RIG-I-like receptor signaling pathway	3/1239	62/7206	0.00621390708138
ko04626	Plant-pathogen interaction	8/1239	18/7206	0.00642444384295
ko04932	Non-alcoholic fatty liver disease (NAFLD)	18/1239	182/7206	0.00696613849233
ko04015	Rap1 signaling pathway	65/1239	278/7206	0.00729612185614
ko04962	Vasopressin-regulated water reabsorption	18/1239	58/7206	0.00825659061891
ko01200	Carbon metabolism	11/1239	128/7206	0.00877455274443
ko04217	Necroptosis	18/1239	178/7206	0.00887110529698
ko04658	Th1 and Th2 cell differentiation	7/1239	96/7206	0.00892602979595
ko05133	Pertussis	6/1239	87/7206	0.00926545718075
ko04270	Vascular smooth muscle contraction	39/1239	154/7206	0.00935126576405
ko04964	Proximal tubule bicarbonate reclamation	11/1239	29/7206	0.010449482153
ko04115	p53 signaling pathway	5/1239	74/7206	0.0128571391994
ko05161	Hepatitis B	18/1239	173/7206	0.0142673844457
ko00982	Drug metabolism - cytochrome P450	1/1239	37/7206	0.0145058856425
ko03410	Base excision repair	1/1239	38/7206	0.0151609515501
ko00620	Pyruvate metabolism	2/1239	46/7206	0.0171503039249
ko04214	Apoptosis - fly	5/1239	72/7206	0.0177761169989
ko05321	Inflammatory bowel disease (IBD)	3/1239	56/7206	0.0189175603876
ko04912	GnRH signaling pathway	31/1239	122/7206	0.0208118292151
ko04657	IL-17 signaling pathway	7/1239	87/7206	0.021395247959
ko04975	Fat digestion and absorption	1/1239	35/7206	0.0220371547719
ko04930	Type II diabetes mellitus	16/1239	54/7206	0.0274407036186
ko04142	Lysosome	16/1239	151/7206	0.0289493423456
ko01524	Platinum drug resistance	6/1239	76/7206	0.0312267106927
ko04620	Toll-like receptor signaling pathway	9/1239	100/7206	0.0315697475125
ko00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	9/1239	26/7206	0.0319361530158
ko00980	Metabolism of xenobiotics by cytochrome P450	2/1239	40/7206	0.0357982992985
ko00140	Steroid hormone biosynthesis	2/1239	41/7206	0.0359821447702
ko00380	Tryptophan metabolism	3/1239	50/7206	0.0366586304969
ko00983	Drug metabolism - other enzymes	2/1239	42/7206	0.0371131650987
ko00310	Lysine degradation	6/1239	73/7206	0.0418295838298
ko05145	Toxoplasmosis	13/1239	126/7206	0.0420654836607
ko04918	Thyroid hormone synthesis	22/1239	86/7206	0.0439227259483
ko05034	Alcoholism	53/1239	238/7206	0.0439572524149
ko05410	Hypertrophic cardiomyopathy (HCM)	25/1239	100/7206	0.0445967197241
ko05340	Primary immunodeficiency	1/1239	30/7206	0.0488533471665
ko04670	Leukocyte transendothelial migration	17/1239	151/7206	0.0499288263959