ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	205/1167	423/7206	3.99130124512e-58
ko04724	Glutamatergic synapse	89/1167	152/7206	3.32429758127e-33
ko05033	Nicotine addiction	48/1167	56/7206	1.85106788214e-30
ko05032	Morphine addiction	68/1167	110/7206	1.44999772254e-27
ko04713	Circadian entrainment	77/1167	136/7206	1.73101553406e-27
ko04727	GABAergic synapse	66/1167	110/7206	1.04725167738e-25
ko04721	Synaptic vesicle cycle	52/1167	80/7206	8.14048681631e-23
ko04728	Dopaminergic synapse	86/1167	185/7206	1.1490454414e-22
ko04725	Cholinergic synapse	78/1167	160/7206	2.89760360491e-22
ko04024	cAMP signaling pathway	106/1167	279/7206	2.4262945577e-19
ko04723	Retrograde endocannabinoid signaling	78/1167	175/7206	2.86797037251e-19
ko04020	Calcium signaling pathway	100/1167	265/7206	7.22818688408e-18
ko04742	Taste transduction	39/1167	61/7206	4.83930754797e-17
ko04911	Insulin secretion	57/1167	117/7206	1.48964155298e-16
ko04726	Serotonergic synapse	60/1167	137/7206	1.17696256331e-14
ko04921	Oxytocin signaling pathway	79/1167	209/7206	1.80572724066e-14
ko04261	Adrenergic signaling in cardiomyocytes	76/1167	205/7206	2.60388951521e-13
ko04744	Phototransduction	25/1167	36/7206	1.33857697952e-12
ko04720	Long-term potentiation	45/1167	99/7206	5.3865979391e-12
ko05031	Amphetamine addiction	42/1167	91/7206	1.49710885782e-11
ko04970	Salivary secretion	43/1167	95/7206	1.91220146691e-11
ko04740	Olfactory transduction	37/1167	80/7206	2.29431437104e-10
ko03040	Spliceosome	1/1167	145/7206	3.17197686327e-10
ko04925	Aldosterone synthesis and secretion	43/1167	105/7206	9.6944390296e-10
ko04360	Axon guidance	74/1167	233/7206	2.01165059385e-09
ko04022	cGMP-PKG signaling pathway	68/1167	216/7206	1.59683532028e-08
ko05030	Cocaine addiction	31/1167	73/7206	7.93675720576e-08
ko04971	Gastric acid secretion	38/1167	98/7206	8.02815358053e-08
ko05203	Viral carcinogenesis	16/1167	277/7206	1.1675598052e-07
ko05168	Herpes simplex infection	7/1167	182/7206	2.08729427628e-07
ko04060	Cytokine-cytokine receptor interaction	8/1167	191/7206	2.50197668492e-07
ko04961	Endocrine and other factor-regulated calcium reabsorption	25/1167	59/7206	1.50874640694e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	29/1167	74/7206	1.57035149035e-06
ko03013	RNA transport	7/1167	166/7206	1.89871881603e-06
ko04924	Renin secretion	32/1167	86/7206	1.99249499962e-06
ko04540	Gap junction	42/1167	128/7206	2.62111540404e-06
ko05322	Systemic lupus erythematosus	6/1167	151/7206	3.34112331249e-06
ko04010	MAPK signaling pathway	83/1167	321/7206	5.89077477614e-06
ko04120	Ubiquitin mediated proteolysis	5/1167	138/7206	5.93025041668e-06
ko04972	Pancreatic secretion	37/1167	111/7206	6.63472069206e-06
ko04966	Collecting duct acid secretion	14/1167	26/7206	1.11307249728e-05
ko04730	Long-term depression	28/1167	78/7206	1.80119154861e-05
ko05164	Influenza A	9/1167	167/7206	2.6985182999e-05
ko04745	Phototransduction - fly	17/1167	38/7206	3.09013200644e-05
ko04750	Inflammatory mediator regulation of TRP channels	38/1167	122/7206	3.18421037439e-05
ko05110	Vibrio cholerae infection	24/1167	63/7206	3.56519449765e-05
ko04976	Bile secretion	28/1167	80/7206	4.03627095463e-05
ko04072	Phospholipase D signaling pathway	54/1167	197/7206	4.94128887045e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1167	79/7206	7.82476205039e-05
ko04514	Cell adhesion molecules (CAMs)	39/1167	130/7206	9.12524434264e-05
ko04141	Protein processing in endoplasmic reticulum	12/1167	184/7206	0.000101761627984
ko04260	Cardiac muscle contraction	31/1167	98/7206	0.000139145577467
ko04110	Cell cycle	8/1167	145/7206	0.000140057759929
ko05414	Dilated cardiomyopathy	34/1167	112/7206	0.000145832364919
ko04070	Phosphatidylinositol signaling system	34/1167	112/7206	0.000145832364919
ko03008	Ribosome biogenesis in eukaryotes	2/1167	79/7206	0.00017243001153
ko05162	Measles	6/1167	120/7206	0.000245737959398
ko04621	NOD-like receptor signaling pathway	10/1167	157/7206	0.000270370562514
ko04014	Ras signaling pathway	68/1167	279/7206	0.000336875740519
ko05140	Leishmaniasis	2/1167	75/7206	0.000387956661895
ko04915	Estrogen signaling pathway	37/1167	131/7206	0.000441336794376
ko05169	Epstein-Barr virus infection	16/1167	206/7206	0.000496485128132
ko05205	Proteoglycans in cancer	24/1167	271/7206	0.000526783075758
ko04626	Plant-pathogen interaction	9/1167	18/7206	0.000897390517326
ko04610	Complement and coagulation cascades	3/1167	79/7206	0.00104685744594
ko04964	Proximal tubule bicarbonate reclamation	12/1167	29/7206	0.00107973118282
ko04146	Peroxisome	4/1167	89/7206	0.0012118139924
ko04371	Apelin signaling pathway	45/1167	177/7206	0.00130365563411
ko00480	Glutathione metabolism	1/1167	55/7206	0.0013388907965
ko04612	Antigen processing and presentation	3/1167	77/7206	0.00153978901626
ko04640	Hematopoietic cell lineage	2/1167	64/7206	0.00181585402461
ko04064	NF-kappa B signaling pathway	5/1167	96/7206	0.00185800953873
ko00590	Arachidonic acid metabolism	1/1167	52/7206	0.00198386713011
ko00310	Lysine degradation	3/1167	73/7206	0.00218455356071
ko04923	Regulation of lipolysis in adipocytes	23/1167	77/7206	0.00262967326515
ko00330	Arginine and proline metabolism	2/1167	61/7206	0.00266488479535
ko00240	Pyrimidine metabolism	7/1167	110/7206	0.00369173254032
ko04932	Non-alcoholic fatty liver disease (NAFLD)	16/1167	182/7206	0.00423653994542
ko03420	Nucleotide excision repair	1/1167	46/7206	0.00445042948444
ko00260	Glycine, serine and threonine metabolism	1/1167	48/7206	0.00471098519577
ko05321	Inflammatory bowel disease (IBD)	2/1167	56/7206	0.00572446609788
ko03022	Basal transcription factors	1/1167	44/7206	0.00668557271501
ko00071	Fatty acid degradation	1/1167	45/7206	0.00688747142316
ko03018	RNA degradation	5/1167	84/7206	0.00697639584549
ko04912	GnRH signaling pathway	31/1167	122/7206	0.00870153429788
ko04214	Apoptosis - fly	4/1167	72/7206	0.00967000092127
ko05131	Shigellosis	5/1167	82/7206	0.00971443398838
ko04270	Vascular smooth muscle contraction	37/1167	154/7206	0.0106663234778
ko05166	HTLV-I infection	32/1167	292/7206	0.0118110421807
ko04217	Necroptosis	17/1167	178/7206	0.0131372968965
ko04330	Notch signaling pathway	3/1167	62/7206	0.0137905904862
ko04622	RIG-I-like receptor signaling pathway	3/1167	62/7206	0.0137905904862
ko04916	Melanogenesis	34/1167	142/7206	0.0152743134445
ko04015	Rap1 signaling pathway	60/1167	278/7206	0.0158585076925
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1167	14/7206	0.0165574426086
ko04658	Th1 and Th2 cell differentiation	7/1167	96/7206	0.0167389734577
ko04657	IL-17 signaling pathway	6/1167	87/7206	0.0179554402851
ko05133	Pertussis	6/1167	87/7206	0.0179554402851
ko05410	Hypertrophic cardiomyopathy (HCM)	25/1167	100/7206	0.0200440261493
ko05161	Hepatitis B	17/1167	173/7206	0.0210655777237
ko04630	Jak-STAT signaling pathway	12/1167	132/7206	0.0231821210399
ko04071	Sphingolipid signaling pathway	37/1167	162/7206	0.0235026173224
ko04115	p53 signaling pathway	5/1167	74/7206	0.0253137131763
ko05144	Malaria	2/1167	45/7206	0.0256034102863
ko05231	Choline metabolism in cancer	31/1167	134/7206	0.0328055762447
ko00860	Porphyrin and chlorophyll metabolism	1/1167	34/7206	0.0334288702496
ko04114	Oocyte meiosis	32/1167	139/7206	0.0355160832333
ko04973	Carbohydrate digestion and absorption	12/1167	42/7206	0.0358254301422
ko05145	Toxoplasmosis	12/1167	126/7206	0.0381422085033
ko01200	Carbon metabolism	12/1167	128/7206	0.0385695129881
ko00280	Valine, leucine and isoleucine degradation	3/1167	54/7206	0.0387089442798
ko04210	Apoptosis	19/1167	180/7206	0.0398579682565
ko04350	TGF-beta signaling pathway	9/1167	103/7206	0.0421465622494
ko03320	PPAR signaling pathway	5/1167	69/7206	0.0470900371043
ko05034	Alcoholism	50/1167	238/7206	0.0484693832752