ko pathway ratio_in_study ratio_in_pop p_value ko04260 Cardiac muscle contraction 32/310 98/7206 2.01626362043e-20 ko05410 Hypertrophic cardiomyopathy (HCM) 28/310 100/7206 5.07606203315e-16 ko05414 Dilated cardiomyopathy 27/310 112/7206 9.93126908343e-14 ko01200 Carbon metabolism 27/310 128/7206 3.10416151673e-12 ko00020 Citrate cycle (TCA cycle) 15/310 35/7206 3.41159210076e-12 ko05010 Alzheimer's disease 32/310 202/7206 9.14848738241e-11 ko00010 Glycolysis / Gluconeogenesis 19/310 74/7206 1.5802797619e-10 ko05012 Parkinson's disease 27/310 155/7206 3.27969539485e-10 ko00190 Oxidative phosphorylation 24/310 127/7206 5.87558388973e-10 ko04261 Adrenergic signaling in cardiomyocytes 31/310 205/7206 6.08599568373e-10 ko05016 Huntington's disease 29/310 215/7206 3.22104872413e-08 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 15/310 79/7206 1.01168922534e-06 ko00620 Pyruvate metabolism 11/310 46/7206 2.70561322431e-06 ko04974 Protein digestion and absorption 16/310 96/7206 2.71566315424e-06 ko00710 Carbon fixation in photosynthetic organisms 8/310 27/7206 1.16229300787e-05 ko01230 Biosynthesis of amino acids 14/310 85/7206 1.32564624384e-05 ko05416 Viral myocarditis 11/310 55/7206 1.71516161606e-05 ko04932 Non-alcoholic fatty liver disease (NAFLD) 20/310 182/7206 9.90619116926e-05 ko04510 Focal adhesion 24/310 240/7206 0.000114328173375 ko04964 Proximal tubule bicarbonate reclamation 7/310 29/7206 0.000175431625554 ko04512 ECM-receptor interaction 11/310 79/7206 0.000515411002353 ko04020 Calcium signaling pathway 23/310 265/7206 0.00161896597866 ko00030 Pentose phosphate pathway 6/310 32/7206 0.00212092767627 ko04062 Chemokine signaling pathway 1/310 201/7206 0.00231311449046 ko00680 Methane metabolism 6/310 34/7206 0.00292832682382 ko04022 cGMP-PKG signaling pathway 19/310 216/7206 0.00303429187379 ko00500 Starch and sucrose metabolism 6/310 35/7206 0.00340895498679 ko04072 Phospholipase D signaling pathway 1/310 197/7206 0.00352472514228 ko05203 Viral carcinogenesis 3/310 277/7206 0.00362223433486 ko04921 Oxytocin signaling pathway 18/310 209/7206 0.00471597825823 ko04310 Wnt signaling pathway 1/310 181/7206 0.00489954820214 ko05152 Tuberculosis 1/310 187/7206 0.00507697757999 ko00250 Alanine, aspartate and glutamate metabolism 6/310 38/7206 0.00520420034206 ko05230 Central carbon metabolism in cancer 9/310 81/7206 0.0076843693341 ko01210 2-Oxocarboxylic acid metabolism 4/310 20/7206 0.00942256938001 ko04014 Ras signaling pathway 4/310 279/7206 0.0102097827315 ko03013 RNA transport 1/310 166/7206 0.010443829201 ko04922 Glucagon signaling pathway 12/310 128/7206 0.0122205849474 ko04015 Rap1 signaling pathway 4/310 278/7206 0.0145047687394 ko00330 Arginine and proline metabolism 7/310 61/7206 0.0151541746088 ko00260 Glycine, serine and threonine metabolism 6/310 48/7206 0.0161719155312 ko05167 Kaposi's sarcoma-associated herpesvirus infection 2/310 191/7206 0.0177099011868 ko00220 Arginine biosynthesis 4/310 24/7206 0.0180601999903 ko04610 Complement and coagulation cascades 8/310 79/7206 0.0197052635502 ko04110 Cell cycle 1/310 145/7206 0.0215981350519 ko04723 Retrograde endocannabinoid signaling 14/310 175/7206 0.0220815673845 ko04724 Glutamatergic synapse 1/310 152/7206 0.0229243218595 ko04371 Apelin signaling pathway 14/310 177/7206 0.0234982807239 ko04150 mTOR signaling pathway 2/310 184/7206 0.0251792079408 ko04728 Dopaminergic synapse 2/310 185/7206 0.0253474574878 ko04933 AGE-RAGE signaling pathway in diabetic complications 1/310 135/7206 0.0310919866421 ko04114 Oocyte meiosis 1/310 139/7206 0.0316694685101 ko00051 Fructose and mannose metabolism 5/310 42/7206 0.0329668941387 ko05161 Hepatitis B 2/310 173/7206 0.0350497916803 ko05200 Pathways in cancer 12/310 492/7206 0.0372405413939 ko00071 Fatty acid degradation 5/310 45/7206 0.0427031306558 ko01212 Fatty acid metabolism 6/310 60/7206 0.0431366406345 ko03010 Ribosome 1/310 129/7206 0.0453055009005 ko05142 Chagas disease (American trypanosomiasis) 1/310 130/7206 0.0456498881424 ko04630 Jak-STAT signaling pathway 1/310 132/7206 0.0465634163506 ko04722 Neurotrophin signaling pathway 2/310 160/7206 0.0487040824123 ko04071 Sphingolipid signaling pathway 2/310 162/7206 0.0487639850737 ko04140 Autophagy - animal 2/310 164/7206 0.0490762846014 ko04550 Signaling pathways regulating pluripotency of stem cells 2/310 165/7206 0.0493265793242