ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko05033	Nicotine addiction	33/580	56/7206	1.77887012772e-22
ko04721	Synaptic vesicle cycle	39/580	80/7206	2.87036618881e-22
ko04080	Neuroactive ligand-receptor interaction	96/580	423/7206	3.39755981782e-22
ko04724	Glutamatergic synapse	43/580	152/7206	7.32608525635e-14
ko04728	Dopaminergic synapse	44/580	185/7206	2.57638904065e-11
ko04727	GABAergic synapse	32/580	110/7206	5.61715128855e-11
ko05032	Morphine addiction	32/580	110/7206	5.61715128855e-11
ko04723	Retrograde endocannabinoid signaling	41/580	175/7206	2.08392571357e-10
ko04713	Circadian entrainment	33/580	136/7206	4.98418667268e-09
ko04966	Collecting duct acid secretion	12/580	26/7206	2.23316357137e-07
ko05030	Cocaine addiction	20/580	73/7206	6.98354068385e-07
ko04725	Cholinergic synapse	32/580	160/7206	1.028239965e-06
ko04514	Cell adhesion molecules (CAMs)	28/580	130/7206	1.04373695148e-06
ko04911	Insulin secretion	26/580	117/7206	1.35688158857e-06
ko04060	Cytokine-cytokine receptor interaction	1/580	191/7206	2.57399778895e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	19/580	74/7206	3.84893586005e-06
ko04024	cAMP signaling pathway	45/580	279/7206	4.89943696342e-06
ko05110	Vibrio cholerae infection	17/580	63/7206	6.00780646855e-06
ko04726	Serotonergic synapse	26/580	137/7206	3.72098361936e-05
ko05203	Viral carcinogenesis	6/580	277/7206	3.96694381493e-05
ko05031	Amphetamine addiction	19/580	91/7206	8.89897849938e-05
ko04145	Phagosome	28/580	162/7206	9.76890503062e-05
ko05120	Epithelial cell signaling in Helicobacter pylori infection	19/580	92/7206	0.000103917168662
ko03040	Spliceosome	1/580	145/7206	0.00014106511546
ko05164	Influenza A	2/580	167/7206	0.000143783284524
ko04120	Ubiquitin mediated proteolysis	1/580	138/7206	0.000199923305171
ko04140	Autophagy - animal	2/580	164/7206	0.000211532045242
ko04742	Taste transduction	14/580	61/7206	0.000264695162847
ko05166	HTLV-I infection	9/580	292/7206	0.000595954268999
ko05323	Rheumatoid arthritis	17/580	89/7206	0.000623822955737
ko04961	Endocrine and other factor-regulated calcium reabsorption	13/580	59/7206	0.000662471969947
ko05205	Proteoglycans in cancer	8/580	271/7206	0.00083975225549
ko04260	Cardiac muscle contraction	18/580	98/7206	0.000964775889786
ko05169	Epstein-Barr virus infection	5/580	206/7206	0.00102539079004
ko04611	Platelet activation	3/580	163/7206	0.00115132315925
ko05168	Herpes simplex infection	4/580	182/7206	0.00131477359607
ko00190	Oxidative phosphorylation	21/580	127/7206	0.00138369509602
ko04630	Jak-STAT signaling pathway	2/580	132/7206	0.00190738719688
ko04261	Adrenergic signaling in cardiomyocytes	29/580	205/7206	0.00248507016718
ko04914	Progesterone-mediated oocyte maturation	1/580	104/7206	0.00301415738396
ko03013	RNA transport	4/580	166/7206	0.00356581801097
ko04010	MAPK signaling pathway	40/580	321/7206	0.00451275892386
ko04730	Long-term depression	14/580	78/7206	0.00475848898959
ko04744	Phototransduction	8/580	36/7206	0.00673412311655
ko04950	Maturity onset diabetes of the young	7/580	29/7206	0.00688773398539
ko04621	NOD-like receptor signaling pathway	4/580	157/7206	0.00691391754994
ko05161	Hepatitis B	5/580	173/7206	0.00699316961979
ko05215	Prostate cancer	2/580	111/7206	0.0080270238716
ko05322	Systemic lupus erythematosus	4/580	151/7206	0.00947779220404
ko01521	EGFR tyrosine kinase inhibitor resistance	2/580	106/7206	0.0114209177165
ko00240	Pyrimidine metabolism	2/580	110/7206	0.0118269726066
ko04141	Protein processing in endoplasmic reticulum	6/580	184/7206	0.0126845543909
ko04110	Cell cycle	4/580	145/7206	0.0129875985831
ko04137	Mitophagy - animal	1/580	82/7206	0.0135335838541
ko03018	RNA degradation	1/580	84/7206	0.0137230483784
ko05220	Chronic myeloid leukemia	1/580	85/7206	0.0139659324946
ko04213	Longevity regulating pathway - multiple species	1/580	86/7206	0.0143089538221
ko05206	MicroRNAs in cancer	6/580	177/7206	0.0168441281562
ko04218	Cellular senescence	6/580	177/7206	0.0168441281562
ko04217	Necroptosis	6/580	178/7206	0.0169087316374
ko01522	Endocrine resistance	3/580	124/7206	0.0180149858602
ko04612	Antigen processing and presentation	1/580	77/7206	0.0196910499317
ko03008	Ribosome biogenesis in eukaryotes	1/580	79/7206	0.0199699817435
ko04972	Pancreatic secretion	16/580	111/7206	0.020538386464
ko00604	Glycosphingolipid biosynthesis - ganglio series	4/580	14/7206	0.0216707168301
ko04970	Salivary secretion	14/580	95/7206	0.0221886223562
ko04910	Insulin signaling pathway	6/580	172/7206	0.0224904190691
ko05418	Fluid shear stress and atherosclerosis	6/580	173/7206	0.0225984187186
ko04064	NF-kappa B signaling pathway	2/580	96/7206	0.0229348213965
ko05146	Amoebiasis	2/580	99/7206	0.0234184057934
ko04962	Vasopressin-regulated water reabsorption	10/580	58/7206	0.023779224684
ko04933	AGE-RAGE signaling pathway in diabetic complications	4/580	135/7206	0.0243359011099
ko04964	Proximal tubule bicarbonate reclamation	6/580	29/7206	0.0254898250256
ko04214	Apoptosis - fly	1/580	72/7206	0.0285954096951
ko04068	FoxO signaling pathway	6/580	167/7206	0.0299167440387
ko00290	Valine, leucine and isoleucine biosynthesis	2/580	4/7206	0.0347817899498
ko04360	Axon guidance	28/580	233/7206	0.036149637424
ko04720	Long-term potentiation	14/580	99/7206	0.0376240429008
ko04978	Mineral absorption	7/580	40/7206	0.0382767768853
ko04919	Thyroid hormone signaling pathway	5/580	143/7206	0.0424108509513
ko04066	HIF-1 signaling pathway	4/580	123/7206	0.0446577110225
ko05145	Toxoplasmosis	4/580	126/7206	0.045281407193
ko05222	Small cell lung cancer	2/580	89/7206	0.0466088079556