ko pathway ratio_in_study ratio_in_pop p_value ko04110 Cell cycle 62/452 145/7206 2.89183465971e-37 ko04111 Cell cycle - yeast 43/452 90/7206 1.78503928099e-28 ko03030 DNA replication 29/452 38/7206 5.42860810278e-28 ko03040 Spliceosome 53/452 145/7206 7.71643497133e-28 ko03460 Fanconi anemia pathway 30/452 51/7206 1.11194818058e-23 ko03440 Homologous recombination 26/452 41/7206 7.14118019887e-22 ko04113 Meiosis - yeast 30/452 70/7206 1.76211604329e-18 ko03430 Mismatch repair 17/452 22/7206 5.31143883679e-17 ko03420 Nucleotide excision repair 22/452 46/7206 4.11751904545e-15 ko03410 Base excision repair 20/452 38/7206 6.92311283111e-15 ko00240 Pyrimidine metabolism 31/452 110/7206 4.09670099467e-13 ko03013 RNA transport 38/452 166/7206 1.15103215743e-12 ko03008 Ribosome biogenesis in eukaryotes 24/452 79/7206 3.40733567509e-11 ko04144 Endocytosis 1/452 342/7206 6.97172150793e-09 ko03015 mRNA surveillance pathway 22/452 93/7206 3.95236831659e-08 ko04810 Regulation of actin cytoskeleton 2/452 264/7206 1.19379271871e-05 ko03018 RNA degradation 17/452 84/7206 1.35688597774e-05 ko04114 Oocyte meiosis 23/452 139/7206 1.51121795265e-05 ko04022 cGMP-PKG signaling pathway 1/452 216/7206 2.15382542378e-05 ko04024 cAMP signaling pathway 3/452 279/7206 2.37022315816e-05 ko04014 Ras signaling pathway 3/452 279/7206 2.37022315816e-05 ko04115 p53 signaling pathway 15/452 74/7206 4.26914564556e-05 ko04218 Cellular senescence 26/452 177/7206 4.63447635566e-05 ko05166 HTLV-I infection 36/452 292/7206 9.90021733002e-05 ko05152 Tuberculosis 1/452 187/7206 0.000100692637466 ko04060 Cytokine-cytokine receptor interaction 1/452 191/7206 0.000103286278713 ko00230 Purine metabolism 27/452 194/7206 0.000111512839696 ko04015 Rap1 signaling pathway 4/452 278/7206 0.000126658321651 ko04510 Focal adhesion 3/452 240/7206 0.000209824923607 ko04723 Retrograde endocannabinoid signaling 1/452 175/7206 0.00021840565311 ko04914 Progesterone-mediated oocyte maturation 17/452 104/7206 0.000227234091799 ko03020 RNA polymerase 8/452 29/7206 0.000299226147379 ko04151 PI3K-Akt signaling pathway 9/452 390/7206 0.000342281390268 ko04072 Phospholipase D signaling pathway 2/452 197/7206 0.000481578523292 ko04142 Lysosome 1/452 151/7206 0.00102056803261 ko04724 Glutamatergic synapse 1/452 152/7206 0.00102902716506 ko05012 Parkinson's disease 1/452 155/7206 0.00108693295449 ko04360 Axon guidance 4/452 233/7206 0.00139955698217 ko03450 Non-homologous end-joining 5/452 15/7206 0.00168519659371 ko04261 Adrenergic signaling in cardiomyocytes 3/452 205/7206 0.00179541033362 ko04910 Insulin signaling pathway 2/452 172/7206 0.0020792251905 ko04010 MAPK signaling pathway 8/452 321/7206 0.00210395645467 ko04931 Insulin resistance 1/452 137/7206 0.00217946422907 ko04611 Platelet activation 2/452 163/7206 0.00292844485975 ko05205 Proteoglycans in cancer 6/452 271/7206 0.00296954387912 ko04380 Osteoclast differentiation 1/452 134/7206 0.0032626044402 ko04713 Circadian entrainment 1/452 136/7206 0.00339420702355 ko04725 Cholinergic synapse 2/452 160/7206 0.00430307242 ko04660 T cell receptor signaling pathway 1/452 124/7206 0.00464438372882 ko05145 Toxoplasmosis 1/452 126/7206 0.00467056042679 ko04932 Non-alcoholic fatty liver disease (NAFLD) 3/452 182/7206 0.00485065034379 ko03010 Ribosome 1/452 129/7206 0.0048752230562 ko04728 Dopaminergic synapse 3/452 185/7206 0.00497508247046 ko04921 Oxytocin signaling pathway 4/452 209/7206 0.00531961973042 ko04668 TNF signaling pathway 1/452 120/7206 0.00682267216094 ko04371 Apelin signaling pathway 3/452 177/7206 0.00685695296942 ko04666 Fc gamma R-mediated phagocytosis 1/452 122/7206 0.0070090708475 ko04062 Chemokine signaling pathway 4/452 201/7206 0.00725703551564 ko05203 Viral carcinogenesis 28/452 277/7206 0.0110176261111 ko04726 Serotonergic synapse 2/452 137/7206 0.0120258652799 ko05222 Small cell lung cancer 12/452 89/7206 0.0122516067758 ko04145 Phagosome 3/452 162/7206 0.0131855923023 ko04140 Autophagy - animal 3/452 164/7206 0.013339748077 ko04925 Aldosterone synthesis and secretion 1/452 105/7206 0.0142666379281 ko04012 ErbB signaling pathway 1/452 109/7206 0.0147189871204 ko04727 GABAergic synapse 1/452 110/7206 0.0149859453483 ko05032 Morphine addiction 1/452 110/7206 0.0149859453483 ko04915 Estrogen signaling pathway 2/452 131/7206 0.0170317314174 ko04630 Jak-STAT signaling pathway 2/452 132/7206 0.0171185861209 ko05231 Choline metabolism in cancer 2/452 134/7206 0.0174626683593 ko03022 Basal transcription factors 7/452 44/7206 0.0185344203013 ko04120 Ubiquitin mediated proteolysis 16/452 138/7206 0.0188410569836 ko00564 Glycerophospholipid metabolism 1/452 99/7206 0.0206704096506 ko04971 Gastric acid secretion 1/452 98/7206 0.020686529383 ko04620 Toll-like receptor signaling pathway 1/452 100/7206 0.0207389688381 ko04520 Adherens junction 1/452 103/7206 0.0214542664864 ko04922 Glucagon signaling pathway 2/452 128/7206 0.0247899437298 ko04670 Leukocyte transendothelial migration 3/452 151/7206 0.0256204571572 ko05120 Epithelial cell signaling in Helicobacter pylori infection 1/452 92/7206 0.0298807645338 ko04658 Th1 and Th2 cell differentiation 1/452 96/7206 0.0307182945847 ko04912 GnRH signaling pathway 2/452 122/7206 0.0350941314766 ko04924 Renin secretion 1/452 86/7206 0.0431090187449 ko05133 Pertussis 1/452 87/7206 0.0432369258838 ko05323 Rheumatoid arthritis 1/452 89/7206 0.0439721695621 ko04972 Pancreatic secretion 2/452 111/7206 0.0472472478812