ko pathway ratio_in_study ratio_in_pop p_value ko05217 Basal cell carcinoma 30/532 68/7206 6.38435152625e-17 ko04550 Signaling pathways regulating pluripotency of stem cells 47/532 165/7206 1.18535533596e-16 ko04310 Wnt signaling pathway 39/532 181/7206 6.29050366375e-10 ko05224 Breast cancer 37/532 174/7206 2.59327415222e-09 ko04390 Hippo signaling pathway 37/532 188/7206 2.36276259099e-08 ko04330 Notch signaling pathway 19/532 62/7206 4.86989286641e-08 ko04340 Hedgehog signaling pathway 18/532 58/7206 8.86442718592e-08 ko04360 Axon guidance 41/532 233/7206 1.24820840424e-07 ko04950 Maturity onset diabetes of the young 12/532 29/7206 3.75818646857e-07 ko04080 Neuroactive ligand-receptor interaction 9/532 423/7206 1.88644322344e-06 ko05202 Transcriptional misregulation in cancer 32/532 188/7206 6.43874612391e-06 ko03040 Spliceosome 26/532 145/7206 1.75311880517e-05 ko04110 Cell cycle 26/532 145/7206 1.75311880517e-05 ko04391 Hippo signaling pathway - fly 18/532 90/7206 8.03232629752e-05 ko05205 Proteoglycans in cancer 38/532 271/7206 0.000116626951534 ko04144 Endocytosis 9/532 342/7206 0.000179112962527 ko04724 Glutamatergic synapse 1/532 152/7206 0.000213333248573 ko04111 Cell cycle - yeast 17/532 90/7206 0.000261171642316 ko03015 mRNA surveillance pathway 17/532 93/7206 0.000391794841324 ko04072 Phospholipase D signaling pathway 3/532 197/7206 0.000429032055246 ko03050 Proteasome 12/532 54/7206 0.000450413206585 ko05200 Pathways in cancer 57/532 492/7206 0.000470547794878 ko04725 Cholinergic synapse 2/532 160/7206 0.000657064585757 ko04921 Oxytocin signaling pathway 4/532 209/7206 0.000684383568872 ko04726 Serotonergic synapse 1/532 137/7206 0.000701180196174 ko04932 Non-alcoholic fatty liver disease (NAFLD) 3/532 182/7206 0.000829704204611 ko05012 Parkinson's disease 2/532 155/7206 0.000947710012481 ko05010 Alzheimer's disease 4/532 202/7206 0.000961466320992 ko01200 Carbon metabolism 1/532 128/7206 0.000969962891558 ko05166 HTLV-I infection 37/532 292/7206 0.00121297050202 ko03410 Base excision repair 9/532 38/7206 0.00142896056679 ko03030 DNA replication 9/532 38/7206 0.00142896056679 ko04910 Insulin signaling pathway 3/532 172/7206 0.00167720307248 ko04723 Retrograde endocannabinoid signaling 3/532 175/7206 0.0017521928135 ko04020 Calcium signaling pathway 8/532 265/7206 0.00373954435109 ko04350 TGF-beta signaling pathway 16/532 103/7206 0.00374682701498 ko04062 Chemokine signaling pathway 5/532 201/7206 0.00380911173061 ko05130 Pathogenic Escherichia coli infection 13/532 77/7206 0.00383811751716 ko05231 Choline metabolism in cancer 2/532 134/7206 0.00404463156791 ko04727 GABAergic synapse 1/532 110/7206 0.00472713809473 ko04916 Melanogenesis 20/532 142/7206 0.00500173555894 ko04341 Hedgehog signaling pathway - fly 8/532 38/7206 0.00566505330962 ko03010 Ribosome 2/532 129/7206 0.00580138175313 ko04915 Estrogen signaling pathway 2/532 131/7206 0.00597218122803 ko05169 Epstein-Barr virus infection 26/532 206/7206 0.00637681177726 ko04060 Cytokine-cytokine receptor interaction 5/532 191/7206 0.00716309530485 ko04211 Longevity regulating pathway 2/532 123/7206 0.00823516834732 ko05211 Renal cell carcinoma 1/532 96/7206 0.00953216692242 ko04650 Natural killer cell mediated cytotoxicity 1/532 97/7206 0.0096285471672 ko04141 Protein processing in endoplasmic reticulum 5/532 184/7206 0.00970520328469 ko04971 Gastric acid secretion 1/532 98/7206 0.00978494129647 ko04720 Long-term potentiation 1/532 99/7206 0.0100021296027 ko04013 MAPK signaling pathway - fly 16/532 115/7206 0.0114038966128 ko04612 Antigen processing and presentation 12/532 77/7206 0.0128687812341 ko04022 cGMP-PKG signaling pathway 7/532 216/7206 0.0164451654511 ko04113 Meiosis - yeast 11/532 70/7206 0.0173954672288 ko04630 Jak-STAT signaling pathway 3/532 132/7206 0.0177990430271 ko05206 MicroRNAs in cancer 22/532 177/7206 0.0184690601411 ko01230 Biosynthesis of amino acids 1/532 85/7206 0.0201367099473 ko04925 Aldosterone synthesis and secretion 2/532 105/7206 0.0233377362921 ko00190 Oxidative phosphorylation 3/532 127/7206 0.0247247423314 ko04922 Glucagon signaling pathway 3/532 128/7206 0.0249130444696 ko04610 Complement and coagulation cascades 1/532 79/7206 0.0291188648846 ko04740 Olfactory transduction 1/532 80/7206 0.0292995107981 ko04138 Autophagy - yeast 1/532 81/7206 0.0296410435159 ko00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin 5/532 26/7206 0.0388117142036 ko04371 Apelin signaling pathway 6/532 177/7206 0.0402223720636 ko01524 Platinum drug resistance 1/532 76/7206 0.0431809961196 ko04621 NOD-like receptor signaling pathway 5/532 157/7206 0.0432064257011 ko04931 Insulin resistance 4/532 137/7206 0.0457461533162 ko04512 ECM-receptor interaction 11/532 79/7206 0.0462544007084 ko04911 Insulin secretion 3/532 117/7206 0.0473669227981