ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko05033	Nicotine addiction	35/572	56/7206	3.18946841749e-25
ko04080	Neuroactive ligand-receptor interaction	100/572	423/7206	4.40788619677e-25
ko04724	Glutamatergic synapse	51/572	152/7206	4.45418205075e-20
ko05032	Morphine addiction	43/572	110/7206	5.1240743302e-20
ko04727	GABAergic synapse	40/572	110/7206	2.22339636457e-17
ko04723	Retrograde endocannabinoid signaling	47/572	175/7206	2.45669673452e-14
ko04728	Dopaminergic synapse	45/572	185/7206	4.06634381687e-12
ko04024	cAMP signaling pathway	57/572	279/7206	1.19399851661e-11
ko04713	Circadian entrainment	34/572	136/7206	8.65559410102e-10
ko04020	Calcium signaling pathway	49/572	265/7206	1.71524463885e-08
ko04261	Adrenergic signaling in cardiomyocytes	41/572	205/7206	2.02897250362e-08
ko04010	MAPK signaling pathway	54/572	321/7206	7.09739741876e-08
ko05030	Cocaine addiction	21/572	73/7206	1.16395759909e-07
ko04725	Cholinergic synapse	33/572	160/7206	2.39017095858e-07
ko04911	Insulin secretion	27/572	117/7206	2.87718336068e-07
ko04921	Oxytocin signaling pathway	39/572	209/7206	3.3746422318e-07
ko04742	Taste transduction	18/572	61/7206	6.19565046064e-07
ko04072	Phospholipase D signaling pathway	36/572	197/7206	1.58395124985e-06
ko05203	Viral carcinogenesis	4/572	277/7206	2.2245243094e-06
ko04721	Synaptic vesicle cycle	20/572	80/7206	2.70966461802e-06
ko05414	Dilated cardiomyopathy	24/572	112/7206	5.33135899201e-06
ko05031	Amphetamine addiction	21/572	91/7206	6.07080150004e-06
ko04514	Cell adhesion molecules (CAMs)	26/572	130/7206	8.29830597325e-06
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	19/572	79/7206	8.86690320532e-06
ko04744	Phototransduction	12/572	36/7206	1.18481018449e-05
ko04720	Long-term potentiation	21/572	99/7206	2.42219288325e-05
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/572	14/7206	4.01013573356e-05
ko04970	Salivary secretion	20/572	95/7206	4.23031508871e-05
ko04360	Axon guidance	35/572	233/7206	0.000189131011583
ko00515	Mannose type O-glycan biosynthesis	8/572	25/7206	0.000481793724339
ko04925	Aldosterone synthesis and secretion	19/572	105/7206	0.000680246220906
ko04260	Cardiac muscle contraction	18/572	98/7206	0.000888789833396
ko04060	Cytokine-cytokine receptor interaction	4/572	191/7206	0.000953039090564
ko05410	Hypertrophic cardiomyopathy (HCM)	18/572	100/7206	0.00101598406842
ko03013	RNA transport	3/572	166/7206	0.00116589747861
ko04726	Serotonergic synapse	22/572	137/7206	0.00121021198525
ko04144	Endocytosis	44/572	342/7206	0.00135097215994
ko04915	Estrogen signaling pathway	21/572	131/7206	0.00163290111689
ko01200	Carbon metabolism	2/572	128/7206	0.00275645188221
ko04022	cGMP-PKG signaling pathway	30/572	216/7206	0.00291384707648
ko05231	Choline metabolism in cancer	21/572	134/7206	0.00301303418428
ko00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	7/572	26/7206	0.00331475417644
ko04972	Pancreatic secretion	18/572	111/7206	0.00367660500661
ko00190	Oxidative phosphorylation	2/572	127/7206	0.00409770498174
ko04923	Regulation of lipolysis in adipocytes	14/572	77/7206	0.00427909349464
ko04110	Cell cycle	3/572	145/7206	0.00463372296636
ko04145	Phagosome	4/572	162/7206	0.0049632003876
ko04740	Olfactory transduction	14/572	80/7206	0.00506725320814
ko04141	Protein processing in endoplasmic reticulum	5/572	184/7206	0.0052001074346
ko04621	NOD-like receptor signaling pathway	4/572	157/7206	0.0068655467585
ko04070	Phosphatidylinositol signaling system	17/572	112/7206	0.00778701411531
ko04146	Peroxisome	1/572	89/7206	0.00933786995558
ko04670	Leukocyte transendothelial migration	4/572	151/7206	0.00947922955431
ko05322	Systemic lupus erythematosus	4/572	151/7206	0.00947922955431
ko05014	Amyotrophic lateral sclerosis (ALS)	12/572	74/7206	0.0150610271185
ko04350	TGF-beta signaling pathway	2/572	103/7206	0.0162564814125
ko05168	Herpes simplex infection	6/572	182/7206	0.0171546668731
ko04932	Non-alcoholic fatty liver disease (NAFLD)	6/572	182/7206	0.0171546668731
ko03008	Ribosome biogenesis in eukaryotes	1/572	79/7206	0.0198137138099
ko00512	Mucin type O-glycan biosynthesis	6/572	29/7206	0.0239781443556
ko04120	Ubiquitin mediated proteolysis	4/572	138/7206	0.0245833303394
ko05169	Epstein-Barr virus infection	8/572	206/7206	0.0256909807948
ko04750	Inflammatory mediator regulation of TRP channels	17/572	122/7206	0.025765576331
ko02024	Quorum sensing	4/572	15/7206	0.0264803591049
ko00010	Glycolysis / Gluconeogenesis	1/572	74/7206	0.0287866199723
ko05205	Proteoglycans in cancer	12/572	271/7206	0.0288014843482
ko04612	Antigen processing and presentation	1/572	77/7206	0.0302240775603
ko04730	Long-term depression	12/572	78/7206	0.0310752103839
ko04064	NF-kappa B signaling pathway	2/572	96/7206	0.0335538425537
ko04151	PI3K-Akt signaling pathway	20/572	390/7206	0.0337970592193
ko04971	Gastric acid secretion	14/572	98/7206	0.0350685579484
ko05164	Influenza A	6/572	167/7206	0.0406639384207
ko05210	Colorectal cancer	12/572	86/7206	0.0447274878404
ko05145	Toxoplasmosis	4/572	126/7206	0.0448556958186