ko pathway ratio_in_study ratio_in_pop p_value ko04060 Cytokine-cytokine receptor interaction 37/291 191/7206 5.02913791897e-16 ko04380 Osteoclast differentiation 25/291 134/7206 8.66574216107e-11 ko05164 Influenza A 26/291 167/7206 2.21837883074e-09 ko04621 NOD-like receptor signaling pathway 24/291 157/7206 1.37317554638e-08 ko04064 NF-kappa B signaling pathway 18/291 96/7206 3.8159549195e-08 ko05145 Toxoplasmosis 19/291 126/7206 5.81881108661e-07 ko04658 Th1 and Th2 cell differentiation 16/291 96/7206 1.18049284221e-06 ko04623 Cytosolic DNA-sensing pathway 10/291 41/7206 3.64155076528e-06 ko04622 RIG-I-like receptor signaling pathway 12/291 62/7206 5.29189655368e-06 ko05162 Measles 17/291 120/7206 5.56542529665e-06 ko04660 T cell receptor signaling pathway 17/291 124/7206 8.73900044105e-06 ko04672 Intestinal immune network for IgA production 9/291 37/7206 1.15756127185e-05 ko05168 Herpes simplex infection 21/291 182/7206 1.23463114002e-05 ko05161 Hepatitis B 20/291 173/7206 1.94118465203e-05 ko04659 Th17 cell differentiation 15/291 106/7206 2.02290474125e-05 ko05140 Leishmaniasis 12/291 75/7206 3.99795912822e-05 ko05323 Rheumatoid arthritis 13/291 89/7206 5.16254966869e-05 ko04062 Chemokine signaling pathway 21/291 201/7206 5.56402447716e-05 ko04630 Jak-STAT signaling pathway 16/291 132/7206 7.5321299162e-05 ko04666 Fc gamma R-mediated phagocytosis 15/291 122/7206 0.000107217327221 ko05340 Primary immunodeficiency 7/291 30/7206 0.000148860529574 ko04620 Toll-like receptor signaling pathway 13/291 100/7206 0.000175266875326 ko04657 IL-17 signaling pathway 12/291 87/7206 0.000175991722998 ko00140 Steroid hormone biosynthesis 8/291 41/7206 0.00019164969898 ko04668 TNF signaling pathway 14/291 120/7206 0.00031680046748 ko05321 Inflammatory bowel disease (IBD) 9/291 56/7206 0.000359018251007 ko05160 Hepatitis C 16/291 153/7206 0.000425348091963 ko05142 Chagas disease (American trypanosomiasis) 14/291 130/7206 0.000720085285028 ko04611 Platelet activation 16/291 163/7206 0.000856970211759 ko05167 Kaposi's sarcoma-associated herpesvirus infection 18/291 191/7206 0.0010146654816 ko04512 ECM-receptor interaction 10/291 79/7206 0.00120396046764 ko05131 Shigellosis 10/291 82/7206 0.00160715939253 ko04650 Natural killer cell mediated cytotoxicity 11/291 97/7206 0.00173664059986 ko00350 Tyrosine metabolism 6/291 33/7206 0.00181425209623 ko05133 Pertussis 10/291 87/7206 0.00251740070284 ko04662 B cell receptor signaling pathway 10/291 88/7206 0.00274132782723 ko05150 Staphylococcus aureus infection 6/291 36/7206 0.00288253624525 ko05320 Autoimmune thyroid disease 5/291 29/7206 0.00554861725152 ko05034 Alcoholism 2/291 238/7206 0.0064056492889 ko05146 Amoebiasis 10/291 99/7206 0.00641487528751 ko04210 Apoptosis 15/291 180/7206 0.00656246879825 ko00643 Styrene degradation 2/291 4/7206 0.00923863014407 ko05222 Small cell lung cancer 9/291 89/7206 0.00944226222023 ko05120 Epithelial cell signaling in Helicobacter pylori infection 9/291 92/7206 0.0116237255985 ko05152 Tuberculosis 15/291 187/7206 0.0121588072782 ko05016 Huntington's disease 2/291 215/7206 0.0126429933095 ko04640 Hematopoietic cell lineage 7/291 64/7206 0.0141136575482 ko05330 Allograft rejection 4/291 24/7206 0.0146119047656 ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis 2/291 5/7206 0.0149886668343 ko04550 Signaling pathways regulating pluripotency of stem cells 1/291 165/7206 0.015041973276 ko00590 Arachidonic acid metabolism 6/291 52/7206 0.0176061600913 ko05166 HTLV-I infection 20/291 292/7206 0.0211600940102 ko05012 Parkinson's disease 1/291 155/7206 0.0217174519817 ko04810 Regulation of actin cytoskeleton 18/291 264/7206 0.0252937364169 ko00051 Fructose and mannose metabolism 5/291 42/7206 0.0259958616025 ko00360 Phenylalanine metabolism 3/291 17/7206 0.0291162220114 ko04217 Necroptosis 13/291 178/7206 0.0328366763676 ko05144 Malaria 5/291 45/7206 0.0338826143462 ko05332 Graft-versus-host disease 3/291 18/7206 0.033921774269 ko04141 Protein processing in endoplasmic reticulum 2/291 184/7206 0.0351179592452 ko04728 Dopaminergic synapse 2/291 185/7206 0.0352520244091 ko04610 Complement and coagulation cascades 7/291 79/7206 0.039670001777 ko04145 Phagosome 12/291 162/7206 0.0398959516148 ko00966 Glucosinolate biosynthesis 1/291 1/7206 0.0403830141548 ko00401 Novobiocin biosynthesis 1/291 1/7206 0.0403830141548 ko00120 Primary bile acid biosynthesis 3/291 20/7206 0.0446791635622 ko04713 Circadian entrainment 1/291 136/7206 0.0451293346194 ko04068 FoxO signaling pathway 12/291 167/7206 0.0451582841488 ko04120 Ubiquitin mediated proteolysis 1/291 138/7206 0.0456487831552 ko04114 Oocyte meiosis 1/291 139/7206 0.0460078776731 ko04916 Melanogenesis 1/291 142/7206 0.0474806243617