ko pathway ratio_in_study ratio_in_pop p_value ko04080 Neuroactive ligand-receptor interaction 72/435 423/7206 1.44284549352e-16 ko05032 Morphine addiction 31/435 110/7206 1.45010863663e-13 ko04724 Glutamatergic synapse 35/435 152/7206 2.57333977058e-12 ko05033 Nicotine addiction 21/435 56/7206 2.92175733058e-12 ko04911 Insulin secretion 30/435 117/7206 5.35128756245e-12 ko04713 Circadian entrainment 30/435 136/7206 3.09940762342e-10 ko04727 GABAergic synapse 26/435 110/7206 1.00518492248e-09 ko04726 Serotonergic synapse 28/435 137/7206 7.63276661542e-09 ko04744 Phototransduction 14/435 36/7206 7.7299658774e-09 ko04728 Dopaminergic synapse 33/435 185/7206 1.26573497902e-08 ko04725 Cholinergic synapse 30/435 160/7206 1.82145922336e-08 ko04024 cAMP signaling pathway 42/435 279/7206 2.38070949842e-08 ko04723 Retrograde endocannabinoid signaling 31/435 175/7206 4.20430241965e-08 ko04020 Calcium signaling pathway 38/435 265/7206 4.65345769564e-07 ko04721 Synaptic vesicle cycle 18/435 80/7206 8.7001092921e-07 ko04921 Oxytocin signaling pathway 30/435 209/7206 8.86771830398e-06 ko04070 Phosphatidylinositol signaling system 20/435 112/7206 9.8096362551e-06 ko04742 Taste transduction 14/435 61/7206 1.13422764257e-05 ko04720 Long-term potentiation 18/435 99/7206 2.11547396651e-05 ko04261 Adrenergic signaling in cardiomyocytes 28/435 205/7206 3.86682761494e-05 ko04971 Gastric acid secretion 17/435 98/7206 6.67067845416e-05 ko04925 Aldosterone synthesis and secretion 17/435 105/7206 0.000161643793545 ko04072 Phospholipase D signaling pathway 26/435 197/7206 0.000178454478359 ko04750 Inflammatory mediator regulation of TRP channels 18/435 122/7206 0.000346931688602 ko05030 Cocaine addiction 13/435 73/7206 0.000364789409834 ko04960 Aldosterone-regulated sodium reabsorption 9/435 41/7206 0.000606561265104 ko05031 Amphetamine addiction 14/435 91/7206 0.00101841992284 ko04930 Type II diabetes mellitus 10/435 54/7206 0.0012569454023 ko04970 Salivary secretion 14/435 95/7206 0.00156260992785 ko04745 Phototransduction - fly 8/435 38/7206 0.00162246580236 ko04360 Axon guidance 26/435 233/7206 0.00196090950582 ko04540 Gap junction 17/435 128/7206 0.00200195068824 ko04260 Cardiac muscle contraction 14/435 98/7206 0.00211402266417 ko04961 Endocrine and other factor-regulated calcium reabsorption 10/435 59/7206 0.00251902830344 ko04740 Olfactory transduction 12/435 80/7206 0.00285008193625 ko05203 Viral carcinogenesis 6/435 277/7206 0.00292950650098 ko04626 Plant-pathogen interaction 5/435 18/7206 0.00348189438201 ko04972 Pancreatic secretion 15/435 111/7206 0.00354663170385 ko04710 Circadian rhythm 8/435 43/7206 0.00369184568913 ko05014 Amyotrophic lateral sclerosis (ALS) 11/435 74/7206 0.00452136847057 ko04711 Circadian rhythm - fly 4/435 13/7206 0.00604901552173 ko04062 Chemokine signaling pathway 22/435 201/7206 0.00617078660698 ko05168 Herpes simplex infection 3/435 182/7206 0.00682780716317 ko04014 Ras signaling pathway 28/435 279/7206 0.00683647196529 ko04514 Cell adhesion molecules (CAMs) 16/435 130/7206 0.00761103534299 ko04010 MAPK signaling pathway 31/435 321/7206 0.00809448200455 ko04022 cGMP-PKG signaling pathway 23/435 216/7206 0.00810695006057 ko04973 Carbohydrate digestion and absorption 7/435 42/7206 0.011934505399 ko03040 Spliceosome 2/435 145/7206 0.0122857351519 ko00680 Methane metabolism 6/435 34/7206 0.0148476800045 ko05010 Alzheimer's disease 21/435 202/7206 0.0151270851251 ko04966 Collecting duct acid secretion 5/435 26/7206 0.0179569051759 ko04924 Renin secretion 11/435 86/7206 0.0184251871067 ko04918 Thyroid hormone synthesis 11/435 86/7206 0.0184251871067 ko03013 RNA transport 3/435 166/7206 0.0191110658973 ko00290 Valine, leucine and isoleucine biosynthesis 2/435 4/7206 0.0201082167853 ko00562 Inositol phosphate metabolism 11/435 89/7206 0.0213870913618 ko04371 Apelin signaling pathway 18/435 177/7206 0.0250086230954 ko04621 NOD-like receptor signaling pathway 3/435 157/7206 0.0257658039538 ko05205 Proteoglycans in cancer 8/435 271/7206 0.0265224025279 ko04722 Neurotrophin signaling pathway 17/435 160/7206 0.0267142095822 ko04964 Proximal tubule bicarbonate reclamation 5/435 29/7206 0.0279658165632 ko04064 NF-kappa B signaling pathway 1/435 96/7206 0.0300410146385 ko04978 Mineral absorption 6/435 40/7206 0.031304564371 ko00030 Pentose phosphate pathway 5/435 32/7206 0.0409436875031 ko00010 Glycolysis / Gluconeogenesis 9/435 74/7206 0.0428561667978 ko05202 Transcriptional misregulation in cancer 5/435 188/7206 0.0438686326603 ko04071 Sphingolipid signaling pathway 16/435 162/7206 0.0446634325187 ko00604 Glycosphingolipid biosynthesis - ganglio series 3/435 14/7206 0.0483413392694