ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	184/1145	423/7206	1.52427815828e-44
ko04724	Glutamatergic synapse	85/1145	152/7206	2.38935985904e-30
ko05033	Nicotine addiction	47/1145	56/7206	2.21340795618e-29
ko05032	Morphine addiction	66/1145	110/7206	3.36468198005e-26
ko04727	GABAergic synapse	64/1145	110/7206	2.18514191511e-24
ko04728	Dopaminergic synapse	86/1145	185/7206	2.99895904825e-23
ko04713	Circadian entrainment	70/1145	136/7206	2.58843735759e-22
ko04721	Synaptic vesicle cycle	50/1145	80/7206	3.06355455198e-21
ko04725	Cholinergic synapse	75/1145	160/7206	1.14859196081e-20
ko04723	Retrograde endocannabinoid signaling	76/1145	175/7206	1.71009866321e-18
ko04024	cAMP signaling pathway	103/1145	279/7206	2.71375717633e-18
ko04742	Taste transduction	38/1145	61/7206	2.29283424448e-16
ko04911	Insulin secretion	55/1145	117/7206	1.57930128651e-15
ko04360	Axon guidance	83/1145	233/7206	7.95475737648e-14
ko04921	Oxytocin signaling pathway	75/1145	209/7206	7.11559597362e-13
ko04261	Adrenergic signaling in cardiomyocytes	74/1145	205/7206	8.1594378775e-13
ko04020	Calcium signaling pathway	88/1145	265/7206	1.0822333791e-12
ko04726	Serotonergic synapse	56/1145	137/7206	1.33852727579e-12
ko04744	Phototransduction	24/1145	36/7206	9.77744645319e-12
ko05031	Amphetamine addiction	41/1145	91/7206	3.65012162082e-11
ko04720	Long-term potentiation	42/1145	99/7206	2.21577825484e-10
ko03040	Spliceosome	1/1145	145/7206	5.15735288073e-10
ko04970	Salivary secretion	39/1145	95/7206	3.09227865155e-09
ko05030	Cocaine addiction	31/1145	73/7206	5.05173804539e-08
ko05203	Viral carcinogenesis	15/1145	277/7206	8.53530426664e-08
ko03013	RNA transport	5/1145	166/7206	1.33151260849e-07
ko04022	cGMP-PKG signaling pathway	64/1145	216/7206	2.2544425745e-07
ko04925	Aldosterone synthesis and secretion	38/1145	105/7206	2.77163066872e-07
ko05168	Herpes simplex infection	7/1145	182/7206	3.16539950778e-07
ko04971	Gastric acid secretion	36/1145	98/7206	3.96551505302e-07
ko04740	Olfactory transduction	31/1145	80/7206	5.99889578176e-07
ko04060	Cytokine-cytokine receptor interaction	9/1145	191/7206	1.77182963839e-06
ko04540	Gap junction	42/1145	128/7206	1.89306841461e-06
ko05322	Systemic lupus erythematosus	6/1145	151/7206	5.00547553881e-06
ko04010	MAPK signaling pathway	82/1145	321/7206	5.02647306388e-06
ko04120	Ubiquitin mediated proteolysis	5/1145	138/7206	8.91996727951e-06
ko05164	Influenza A	8/1145	167/7206	1.34028598491e-05
ko04514	Cell adhesion molecules (CAMs)	40/1145	130/7206	1.66060906509e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1145	79/7206	1.66419130399e-05
ko04141	Protein processing in endoplasmic reticulum	10/1145	184/7206	2.14946358825e-05
ko03008	Ribosome biogenesis in eukaryotes	1/1145	79/7206	3.27597086992e-05
ko04621	NOD-like receptor signaling pathway	8/1145	157/7206	3.69087512587e-05
ko04924	Renin secretion	29/1145	86/7206	3.80627568402e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	26/1145	74/7206	3.96129167151e-05
ko04745	Phototransduction - fly	16/1145	38/7206	0.000101876864609
ko05414	Dilated cardiomyopathy	34/1145	112/7206	0.000116175195756
ko04260	Cardiac muscle contraction	31/1145	98/7206	0.000119792138228
ko04961	Endocrine and other factor-regulated calcium reabsorption	21/1145	59/7206	0.000200583851666
ko04966	Collecting duct acid secretion	12/1145	26/7206	0.000268211436544
ko00240	Pyrimidine metabolism	5/1145	110/7206	0.000326610312064
ko05162	Measles	6/1145	120/7206	0.000355799974084
ko05140	Leishmaniasis	2/1145	75/7206	0.000389409955218
ko04730	Long-term depression	25/1145	78/7206	0.000438246001333
ko00604	Glycosphingolipid biosynthesis - ganglio series	8/1145	14/7206	0.000484571417456
ko04972	Pancreatic secretion	32/1145	111/7206	0.000545802242796
ko04064	NF-kappa B signaling pathway	4/1145	96/7206	0.000602771532862
ko04932	Non-alcoholic fatty liver disease (NAFLD)	13/1145	182/7206	0.000624343711216
ko04915	Estrogen signaling pathway	36/1145	131/7206	0.000636877594617
ko04750	Inflammatory mediator regulation of TRP channels	34/1145	122/7206	0.000653462621004
ko05169	Epstein-Barr virus infection	16/1145	206/7206	0.000660165644743
ko04916	Melanogenesis	38/1145	142/7206	0.00102326772248
ko04371	Apelin signaling pathway	45/1145	177/7206	0.00112767275461
ko00480	Glutathione metabolism	1/1145	55/7206	0.00132991321497
ko05110	Vibrio cholerae infection	20/1145	63/7206	0.00149054995116
ko04070	Phosphatidylinositol signaling system	31/1145	112/7206	0.0015227900902
ko04146	Peroxisome	4/1145	89/7206	0.00182609867301
ko04014	Ras signaling pathway	64/1145	279/7206	0.0018947375546
ko00590	Arachidonic acid metabolism	1/1145	52/7206	0.00200371102304
ko03018	RNA degradation	4/1145	84/7206	0.0024686501865
ko04640	Hematopoietic cell lineage	2/1145	64/7206	0.00284083934473
ko04072	Phospholipase D signaling pathway	47/1145	197/7206	0.00294467851019
ko05161	Hepatitis B	14/1145	173/7206	0.00306660304957
ko04976	Bile secretion	23/1145	80/7206	0.00313162675249
ko04626	Plant-pathogen interaction	8/1145	18/7206	0.00389496242951
ko01200	Carbon metabolism	9/1145	128/7206	0.00461027991006
ko05205	Proteoglycans in cancer	27/1145	271/7206	0.00511131656211
ko03022	Basal transcription factors	1/1145	44/7206	0.00679291621033
ko05144	Malaria	1/1145	45/7206	0.00679662292702
ko00071	Fatty acid degradation	1/1145	45/7206	0.00679662292702
ko04612	Antigen processing and presentation	4/1145	77/7206	0.00702692882563
ko03420	Nucleotide excision repair	1/1145	46/7206	0.00703491137353
ko04630	Jak-STAT signaling pathway	10/1145	132/7206	0.00766992441158
ko04391	Hippo signaling pathway - fly	24/1145	90/7206	0.00832920518465
ko05321	Inflammatory bowel disease (IBD)	2/1145	56/7206	0.00880764498813
ko04110	Cell cycle	12/1145	145/7206	0.0110054132478
ko04620	Toll-like receptor signaling pathway	7/1145	100/7206	0.0124403066793
ko05145	Toxoplasmosis	10/1145	126/7206	0.0132391494488
ko00330	Arginine and proline metabolism	3/1145	61/7206	0.0133942684662
ko04622	RIG-I-like receptor signaling pathway	3/1145	62/7206	0.0134800569285
ko00561	Glycerolipid metabolism	3/1145	63/7206	0.0138539252285
ko05131	Shigellosis	5/1145	82/7206	0.0139091524902
ko04214	Apoptosis - fly	4/1145	72/7206	0.0139204010824
ko00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	9/1145	26/7206	0.0151142276302
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1145	40/7206	0.0152552638853
ko05133	Pertussis	6/1145	87/7206	0.0177170320888
ko00380	Tryptophan metabolism	2/1145	50/7206	0.0180983335001
ko05410	Hypertrophic cardiomyopathy (HCM)	25/1145	100/7206	0.018217564087
ko03320	PPAR signaling pathway	4/1145	69/7206	0.0192817125924
ko04668	TNF signaling pathway	10/1145	120/7206	0.0225671047824
ko00982	Drug metabolism - cytochrome P450	1/1145	37/7206	0.0225893812216
ko04912	GnRH signaling pathway	29/1145	122/7206	0.0236115918453
ko04270	Vascular smooth muscle contraction	35/1145	154/7206	0.0251774879153
ko01524	Platinum drug resistance	5/1145	76/7206	0.0257982423503
ko00620	Pyruvate metabolism	2/1145	46/7206	0.0258299169435
ko04923	Regulation of lipolysis in adipocytes	20/1145	77/7206	0.0264955423901
ko05219	Bladder cancer	2/1145	48/7206	0.0267048254657
ko04962	Vasopressin-regulated water reabsorption	16/1145	58/7206	0.0280859711337
ko04210	Apoptosis	18/1145	180/7206	0.0295703586479
ko04115	p53 signaling pathway	5/1145	74/7206	0.0357604901637
ko00600	Sphingolipid metabolism	4/1145	63/7206	0.0367147333081
ko04918	Thyroid hormone synthesis	21/1145	86/7206	0.03688966767
ko04964	Proximal tubule bicarbonate reclamation	9/1145	29/7206	0.037677777783
ko00280	Valine, leucine and isoleucine degradation	3/1145	54/7206	0.0380253478706
ko04062	Chemokine signaling pathway	43/1145	201/7206	0.0391901417575
ko04142	Lysosome	15/1145	151/7206	0.0426680985646
ko05418	Fluid shear stress and atherosclerosis	18/1145	173/7206	0.0454000916558
ko04114	Oocyte meiosis	31/1145	139/7206	0.0455284093821
ko05034	Alcoholism	49/1145	238/7206	0.047301155729
ko04136	Autophagy - other	1/1145	31/7206	0.0498291127944