ko pathway ratio_in_study ratio_in_pop p_value ko03040 Spliceosome 53/438 145/7206 1.5802121046e-28 ko03440 Homologous recombination 21/438 41/7206 1.5681324717e-15 ko03008 Ribosome biogenesis in eukaryotes 28/438 79/7206 4.01952150668e-15 ko03013 RNA transport 39/438 166/7206 8.38604434602e-14 ko04110 Cell cycle 36/438 145/7206 1.31505324347e-13 ko04111 Cell cycle - yeast 27/438 90/7206 1.28622085631e-12 ko03460 Fanconi anemia pathway 20/438 51/7206 4.15054471327e-12 ko03030 DNA replication 17/438 38/7206 1.36895933943e-11 ko00240 Pyrimidine metabolism 25/438 110/7206 5.84356143844e-09 ko04113 Meiosis - yeast 19/438 70/7206 1.86968013084e-08 ko04144 Endocytosis 2/438 342/7206 1.59668653228e-07 ko03410 Base excision repair 13/438 38/7206 1.73023279565e-07 ko05322 Systemic lupus erythematosus 26/438 151/7206 1.07582399229e-06 ko03018 RNA degradation 18/438 84/7206 2.05273027667e-06 ko03430 Mismatch repair 9/438 22/7206 2.55016622117e-06 ko04151 PI3K-Akt signaling pathway 5/438 390/7206 3.14603935867e-06 ko04022 cGMP-PKG signaling pathway 1/438 216/7206 3.2020737538e-05 ko04024 cAMP signaling pathway 3/438 279/7206 5.20530269528e-05 ko05010 Alzheimer's disease 1/438 202/7206 6.91950305183e-05 ko03420 Nucleotide excision repair 11/438 46/7206 7.07131275152e-05 ko04072 Phospholipase D signaling pathway 1/438 197/7206 0.00010411025116 ko03022 Basal transcription factors 10/438 44/7206 0.000237114248979 ko03020 RNA polymerase 8/438 29/7206 0.000241117645514 ko04510 Focal adhesion 3/438 240/7206 0.000302248126077 ko04921 Oxytocin signaling pathway 2/438 209/7206 0.000333692077046 ko04261 Adrenergic signaling in cardiomyocytes 2/438 205/7206 0.000495534865551 ko04810 Regulation of actin cytoskeleton 4/438 264/7206 0.00052409379843 ko04530 Tight junction 3/438 228/7206 0.000613710302493 ko04152 AMPK signaling pathway 1/438 161/7206 0.000699339912082 ko04014 Ras signaling pathway 5/438 279/7206 0.000788273081317 ko04060 Cytokine-cytokine receptor interaction 2/438 191/7206 0.00101815934077 ko05012 Parkinson's disease 1/438 155/7206 0.00102550415639 ko04621 NOD-like receptor signaling pathway 1/438 157/7206 0.00103885561045 ko03450 Non-homologous end-joining 5/438 15/7206 0.00146327185699 ko04728 Dopaminergic synapse 2/438 185/7206 0.00147578886584 ko04724 Glutamatergic synapse 1/438 152/7206 0.0015555774916 ko00230 Purine metabolism 23/438 194/7206 0.00192611550231 ko04723 Retrograde endocannabinoid signaling 2/438 175/7206 0.00205914770381 ko04371 Apelin signaling pathway 2/438 177/7206 0.00208240086943 ko04015 Rap1 signaling pathway 6/438 278/7206 0.00294513585885 ko04910 Insulin signaling pathway 2/438 172/7206 0.00304201469851 ko04713 Circadian entrainment 1/438 136/7206 0.00321278946459 ko04630 Jak-STAT signaling pathway 1/438 132/7206 0.00480926931781 ko04914 Progesterone-mediated oocyte maturation 14/438 104/7206 0.00533978678297 ko04114 Oocyte meiosis 17/438 139/7206 0.00588166786009 ko04725 Cholinergic synapse 2/438 160/7206 0.00632777007723 ko04750 Inflammatory mediator regulation of TRP channels 1/438 122/7206 0.00680276691558 ko04666 Fc gamma R-mediated phagocytosis 1/438 122/7206 0.00680276691558 ko04932 Non-alcoholic fatty liver disease (NAFLD) 3/438 182/7206 0.00685924367589 ko05034 Alcoholism 25/438 238/7206 0.00792752429663 ko05166 HTLV-I infection 29/438 292/7206 0.00816225175934 ko04010 MAPK signaling pathway 9/438 321/7206 0.00835546849539 ko04062 Chemokine signaling pathway 4/438 201/7206 0.0100577107689 ko04668 TNF signaling pathway 1/438 120/7206 0.0103721436041 ko05205 Proteoglycans in cancer 7/438 271/7206 0.0128960980007 ko03015 mRNA surveillance pathway 12/438 93/7206 0.0130542472601 ko04115 p53 signaling pathway 10/438 74/7206 0.0134677612567 ko05203 Viral carcinogenesis 27/438 277/7206 0.0140865657059 ko04012 ErbB signaling pathway 1/438 109/7206 0.0143485561827 ko04727 GABAergic synapse 1/438 110/7206 0.0144060001342 ko05032 Morphine addiction 1/438 110/7206 0.0144060001342 ko04070 Phosphatidylinositol signaling system 1/438 112/7206 0.0146933633146 ko04931 Insulin resistance 2/438 137/7206 0.0173036805369 ko04726 Serotonergic synapse 2/438 137/7206 0.0173036805369 ko04611 Platelet activation 3/438 163/7206 0.0186766845646 ko04140 Autophagy - animal 3/438 164/7206 0.0188800036578 ko04659 Th17 cell differentiation 1/438 106/7206 0.0214583861295 ko01521 EGFR tyrosine kinase inhibitor resistance 1/438 106/7206 0.0214583861295 ko00190 Oxidative phosphorylation 2/438 127/7206 0.0240806301666 ko05142 Chagas disease (American trypanosomiasis) 2/438 130/7206 0.0243374596956 ko04514 Cell adhesion molecules (CAMs) 2/438 130/7206 0.0243374596956 ko04915 Estrogen signaling pathway 2/438 131/7206 0.0245661496053 ko04064 NF-kappa B signaling pathway 1/438 96/7206 0.0300503844053 ko04971 Gastric acid secretion 1/438 98/7206 0.0304570199919 ko00564 Glycerophospholipid metabolism 1/438 99/7206 0.0308252367885 ko04660 T cell receptor signaling pathway 2/438 124/7206 0.0344227665597 ko05145 Toxoplasmosis 2/438 126/7206 0.0352845714152 ko00562 Inositol phosphate metabolism 1/438 89/7206 0.0432983136512 ko05152 Tuberculosis 5/438 187/7206 0.0438260660076 ko05167 Kaposi's sarcoma-associated herpesvirus infection 5/438 191/7206 0.0442435839707 ko04360 Axon guidance 7/438 233/7206 0.0494513799455