ko pathway ratio_in_study ratio_in_pop p_value ko04080 Neuroactive ligand-receptor interaction 118/926 423/7206 1.21255659923e-17 ko04020 Calcium signaling pathway 85/926 265/7206 7.31713488661e-17 ko05033 Nicotine addiction 29/926 56/7206 2.23783659074e-12 ko04723 Retrograde endocannabinoid signaling 57/926 175/7206 5.72285042006e-12 ko04921 Oxytocin signaling pathway 64/926 209/7206 6.38868855319e-12 ko04724 Glutamatergic synapse 51/926 152/7206 2.23077901351e-11 ko04713 Circadian entrainment 47/926 136/7206 4.3213153189e-11 ko04022 cGMP-PKG signaling pathway 61/926 216/7206 1.27299810043e-09 ko04911 Insulin secretion 40/926 117/7206 1.78955061749e-09 ko04727 GABAergic synapse 37/926 110/7206 1.20968621917e-08 ko00190 Oxidative phosphorylation 40/926 127/7206 2.57954404687e-08 ko05032 Morphine addiction 36/926 110/7206 4.28426079826e-08 ko04261 Adrenergic signaling in cardiomyocytes 55/926 205/7206 5.50423388088e-08 ko04721 Synaptic vesicle cycle 29/926 80/7206 7.23900272281e-08 ko05010 Alzheimer's disease 54/926 202/7206 8.24775382074e-08 ko04970 Salivary secretion 32/926 95/7206 1.13470648379e-07 ko04725 Cholinergic synapse 45/926 160/7206 2.23365001548e-07 ko05168 Herpes simplex infection 4/926 182/7206 4.53074224449e-07 ko05203 Viral carcinogenesis 11/926 277/7206 5.31844514731e-07 ko04024 cAMP signaling pathway 66/926 279/7206 5.59863085433e-07 ko03010 Ribosome 1/926 129/7206 7.41702838405e-07 ko04728 Dopaminergic synapse 48/926 185/7206 1.03088121041e-06 ko04922 Glucagon signaling pathway 36/926 128/7206 3.11777419168e-06 ko03040 Spliceosome 3/926 145/7206 6.99233429269e-06 ko01200 Carbon metabolism 35/926 128/7206 1.13956295326e-05 ko03013 RNA transport 5/926 166/7206 1.70017367251e-05 ko05031 Amphetamine addiction 27/926 91/7206 1.99432462382e-05 ko05322 Systemic lupus erythematosus 4/926 151/7206 1.99859863745e-05 ko04726 Serotonergic synapse 36/926 137/7206 2.37181175036e-05 ko04260 Cardiac muscle contraction 28/926 98/7206 2.65099619284e-05 ko04971 Gastric acid secretion 28/926 98/7206 2.65099619284e-05 ko00010 Glycolysis / Gluconeogenesis 23/926 74/7206 3.0588975247e-05 ko04710 Circadian rhythm 16/926 43/7206 4.34366242014e-05 ko04720 Long-term potentiation 28/926 99/7206 4.84402784996e-05 ko05164 Influenza A 6/926 167/7206 5.65166464121e-05 ko05012 Parkinson's disease 38/926 155/7206 7.62496060285e-05 ko01230 Biosynthesis of amino acids 24/926 85/7206 0.000123526471811 ko04110 Cell cycle 5/926 145/7206 0.000142324369045 ko04657 IL-17 signaling pathway 1/926 87/7206 0.000143504018637 ko04745 Phototransduction - fly 14/926 38/7206 0.000147455428169 ko04925 Aldosterone synthesis and secretion 28/926 105/7206 0.000164248079044 ko00020 Citrate cycle (TCA cycle) 13/926 35/7206 0.000230881849158 ko04371 Apelin signaling pathway 40/926 177/7206 0.00035435078724 ko04924 Renin secretion 23/926 86/7206 0.000476306781612 ko05161 Hepatitis B 8/926 173/7206 0.000478250369334 ko05162 Measles 4/926 120/7206 0.000508237814522 ko04630 Jak-STAT signaling pathway 5/926 132/7206 0.000568337763329 ko04270 Vascular smooth muscle contraction 35/926 154/7206 0.000574819751717 ko00680 Methane metabolism 12/926 34/7206 0.00068742580949 ko05410 Hypertrophic cardiomyopathy (HCM) 25/926 100/7206 0.000780183109589 ko04730 Long-term depression 21/926 78/7206 0.000875504303092 ko04932 Non-alcoholic fatty liver disease (NAFLD) 39/926 182/7206 0.00103483416291 ko04120 Ubiquitin mediated proteolysis 6/926 138/7206 0.00117846040104 ko00710 Carbon fixation in photosynthetic organisms 10/926 27/7206 0.00125074454916 ko05169 Epstein-Barr virus infection 12/926 206/7206 0.00139330738547 ko04930 Type II diabetes mellitus 16/926 54/7206 0.00145277531955 ko04060 Cytokine-cytokine receptor interaction 11/926 191/7206 0.0019673579557 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 20/926 79/7206 0.00210401426933 ko04514 Cell adhesion molecules (CAMs) 29/926 130/7206 0.0022275872541 ko05414 Dilated cardiomyopathy 26/926 112/7206 0.00240990105653 ko05014 Amyotrophic lateral sclerosis (ALS) 19/926 74/7206 0.00245533986078 ko01040 Biosynthesis of unsaturated fatty acids 9/926 25/7206 0.0027432090806 ko04960 Aldosterone-regulated sodium reabsorption 12/926 41/7206 0.00421769592154 ko04210 Apoptosis 11/926 180/7206 0.00452504689196 ko04626 Plant-pathogen interaction 7/926 18/7206 0.00497460127784 ko04621 NOD-like receptor signaling pathway 9/926 157/7206 0.00518544422173 ko00030 Pentose phosphate pathway 10/926 32/7206 0.00524719478047 ko00604 Glycosphingolipid biosynthesis - ganglio series 6/926 14/7206 0.00531765603895 ko04742 Taste transduction 16/926 61/7206 0.0057365836373 ko04217 Necroptosis 11/926 178/7206 0.006071169592 ko04070 Phosphatidylinositol signaling system 25/926 112/7206 0.00613442026261 ko04010 MAPK signaling pathway 58/926 321/7206 0.00615148053342 ko04141 Protein processing in endoplasmic reticulum 12/926 184/7206 0.00713531590864 ko05166 HTLV-I infection 23/926 292/7206 0.0073607606789 ko04014 Ras signaling pathway 51/926 279/7206 0.00794698349227 ko04964 Proximal tubule bicarbonate reclamation 9/926 29/7206 0.00836857583838 ko01212 Fatty acid metabolism 15/926 60/7206 0.0100188519942 ko00071 Fatty acid degradation 12/926 45/7206 0.0114708591186 ko04360 Axon guidance 43/926 233/7206 0.0125608652652 ko00620 Pyruvate metabolism 12/926 46/7206 0.0130949792203 ko00240 Pyrimidine metabolism 6/926 110/7206 0.0145771085123 ko05130 Pathogenic Escherichia coli infection 3/926 77/7206 0.0151931260479 ko04612 Antigen processing and presentation 3/926 77/7206 0.0151931260479 ko00051 Fructose and mannose metabolism 11/926 42/7206 0.01764338184 ko05230 Central carbon metabolism in cancer 18/926 81/7206 0.0179728870425 ko04622 RIG-I-like receptor signaling pathway 2/926 62/7206 0.0202173540734 ko04064 NF-kappa B signaling pathway 5/926 96/7206 0.0206016564643 ko04214 Apoptosis - fly 3/926 72/7206 0.0210466772249 ko04152 AMPK signaling pathway 31/926 161/7206 0.0227075758199 ko04750 Inflammatory mediator regulation of TRP channels 24/926 122/7206 0.0286004940161 ko00362 Benzoate degradation 3/926 6/7206 0.0313241612691 ko04972 Pancreatic secretion 22/926 111/7206 0.0319676622022 ko04550 Signaling pathways regulating pluripotency of stem cells 12/926 165/7206 0.0331473551285 ko00120 Primary bile acid biosynthesis 6/926 20/7206 0.0349550499744 ko04620 Toll-like receptor signaling pathway 6/926 100/7206 0.0352057620629 ko05016 Huntington's disease 38/926 215/7206 0.0380110506891 ko04966 Collecting duct acid secretion 7/926 26/7206 0.0411639188917 ko04740 Olfactory transduction 17/926 80/7206 0.0413356715497 ko05321 Inflammatory bowel disease (IBD) 2/926 56/7206 0.0417353652146 ko05215 Prostate cancer 7/926 111/7206 0.0436773888247