ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	193/1000	423/7206	6.95012827668e-61
ko05033	Nicotine addiction	49/1000	56/7206	2.92361956104e-35
ko04724	Glutamatergic synapse	80/1000	152/7206	2.27766014881e-30
ko05032	Morphine addiction	64/1000	110/7206	8.41266831503e-28
ko04727	GABAergic synapse	62/1000	110/7206	6.55223818291e-26
ko04713	Circadian entrainment	67/1000	136/7206	2.03128088085e-23
ko04725	Cholinergic synapse	70/1000	160/7206	1.13278436296e-20
ko04728	Dopaminergic synapse	75/1000	185/7206	1.09331013829e-19
ko04723	Retrograde endocannabinoid signaling	72/1000	175/7206	2.25594894394e-19
ko04721	Synaptic vesicle cycle	43/1000	80/7206	2.88515158261e-17
ko04020	Calcium signaling pathway	86/1000	265/7206	2.70267400783e-15
ko04911	Insulin secretion	51/1000	117/7206	2.74684513625e-15
ko04024	cAMP signaling pathway	89/1000	279/7206	3.01690226361e-15
ko04742	Taste transduction	34/1000	61/7206	1.51290412353e-14
ko04726	Serotonergic synapse	54/1000	137/7206	7.03031104569e-14
ko05031	Amphetamine addiction	39/1000	91/7206	1.03961031417e-11
ko04921	Oxytocin signaling pathway	65/1000	209/7206	7.34393754281e-11
ko04360	Axon guidance	67/1000	233/7206	1.69541018985e-09
ko05030	Cocaine addiction	31/1000	73/7206	1.85076224305e-09
ko04261	Adrenergic signaling in cardiomyocytes	61/1000	205/7206	1.98943987867e-09
ko04720	Long-term potentiation	37/1000	99/7206	3.71756969289e-09
ko03040	Spliceosome	1/1000	145/7206	1.45158222438e-08
ko05203	Viral carcinogenesis	12/1000	277/7206	1.83588549729e-07
ko04970	Salivary secretion	33/1000	95/7206	1.99746761637e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1000	74/7206	2.20001595367e-07
ko05168	Herpes simplex infection	5/1000	182/7206	5.74034445536e-07
ko04925	Aldosterone synthesis and secretion	33/1000	105/7206	2.79188142096e-06
ko04010	MAPK signaling pathway	75/1000	321/7206	2.94386453809e-06
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1000	79/7206	3.65671487333e-06
ko05322	Systemic lupus erythematosus	4/1000	151/7206	3.9591684086e-06
ko04514	Cell adhesion molecules (CAMs)	38/1000	130/7206	4.20094230288e-06
ko04740	Olfactory transduction	27/1000	80/7206	4.80281629192e-06
ko04022	cGMP-PKG signaling pathway	54/1000	216/7206	8.70625879243e-06
ko05164	Influenza A	6/1000	167/7206	1.26423396837e-05
ko04060	Cytokine-cytokine receptor interaction	8/1000	191/7206	1.63437871822e-05
ko03013	RNA transport	6/1000	166/7206	1.87424514917e-05
ko04971	Gastric acid secretion	30/1000	98/7206	2.01959570637e-05
ko04972	Pancreatic secretion	31/1000	111/7206	8.12214770437e-05
ko04120	Ubiquitin mediated proteolysis	5/1000	138/7206	9.241046658e-05
ko04072	Phospholipase D signaling pathway	47/1000	197/7206	0.000141092648068
ko05414	Dilated cardiomyopathy	30/1000	112/7206	0.000266283711293
ko04540	Gap junction	33/1000	128/7206	0.000266447684935
ko04141	Protein processing in endoplasmic reticulum	10/1000	184/7206	0.00031893365764
ko04730	Long-term depression	23/1000	78/7206	0.000361689107268
ko04621	NOD-like receptor signaling pathway	8/1000	157/7206	0.000613445426737
ko00240	Pyrimidine metabolism	4/1000	110/7206	0.000693420849056
ko04924	Renin secretion	24/1000	86/7206	0.000732382617964
ko05205	Proteoglycans in cancer	20/1000	271/7206	0.000887702162623
ko04260	Cardiac muscle contraction	26/1000	98/7206	0.000956651847586
ko04932	Non-alcoholic fatty liver disease (NAFLD)	11/1000	182/7206	0.0010303345643
ko04750	Inflammatory mediator regulation of TRP channels	30/1000	122/7206	0.00133846617319
ko04612	Antigen processing and presentation	2/1000	77/7206	0.00141338517981
ko04610	Complement and coagulation cascades	2/1000	79/7206	0.00147676917471
ko03008	Ribosome biogenesis in eukaryotes	2/1000	79/7206	0.00147676917471
ko04966	Collecting duct acid secretion	10/1000	26/7206	0.00162859144423
ko04146	Peroxisome	3/1000	89/7206	0.00173608267525
ko05140	Leishmaniasis	2/1000	75/7206	0.00208617694715
ko04110	Cell cycle	8/1000	145/7206	0.00215816062136
ko04961	Endocrine and other factor-regulated calcium reabsorption	17/1000	59/7206	0.0022003262211
ko04744	Phototransduction	12/1000	36/7206	0.00241265706738
ko05110	Vibrio cholerae infection	18/1000	63/7206	0.00258919417893
ko04976	Bile secretion	21/1000	80/7206	0.00295310678954
ko05162	Measles	6/1000	120/7206	0.00301715271219
ko04214	Apoptosis - fly	2/1000	72/7206	0.00304110876569
ko05410	Hypertrophic cardiomyopathy (HCM)	25/1000	100/7206	0.00307113949409
ko00310	Lysine degradation	2/1000	73/7206	0.00313699472752
ko04014	Ras signaling pathway	56/1000	279/7206	0.00344772659522
ko04745	Phototransduction - fly	12/1000	38/7206	0.00400656435593
ko05169	Epstein-Barr virus infection	15/1000	206/7206	0.00400724414884
ko00480	Glutathione metabolism	1/1000	55/7206	0.00507035080776
ko05133	Pertussis	4/1000	87/7206	0.007608272044
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/1000	14/7206	0.00781269316489
ko04640	Hematopoietic cell lineage	2/1000	64/7206	0.00956731880991
ko04915	Estrogen signaling pathway	29/1000	131/7206	0.0100417813892
ko04064	NF-kappa B signaling pathway	5/1000	96/7206	0.0107152713918
ko00260	Glycine, serine and threonine metabolism	1/1000	48/7206	0.010987823052
ko05219	Bladder cancer	1/1000	48/7206	0.010987823052
ko04070	Phosphatidylinositol signaling system	25/1000	112/7206	0.0128281245993
ko04371	Apelin signaling pathway	36/1000	177/7206	0.0152027978718
ko04217	Necroptosis	14/1000	178/7206	0.0156449578921
ko05016	Huntington's disease	18/1000	215/7206	0.0159537508972
ko05144	Malaria	1/1000	45/7206	0.0162878098263
ko00071	Fatty acid degradation	1/1000	45/7206	0.0162878098263
ko04930	Type II diabetes mellitus	14/1000	54/7206	0.016313705601
ko03420	Nucleotide excision repair	1/1000	46/7206	0.0165316165203
ko04142	Lysosome	11/1000	151/7206	0.0167122474205
ko05321	Inflammatory bowel disease (IBD)	2/1000	56/7206	0.0191639325475
ko04071	Sphingolipid signaling pathway	33/1000	162/7206	0.0209092488364
ko04140	Autophagy - animal	13/1000	164/7206	0.0223045934458
ko00565	Ether lipid metabolism	1/1000	42/7206	0.0240985889217
ko03022	Basal transcription factors	1/1000	44/7206	0.0253169089659
ko05161	Hepatitis B	14/1000	173/7206	0.0254169183731
ko04658	Th1 and Th2 cell differentiation	6/1000	96/7206	0.025539444557
ko04657	IL-17 signaling pathway	5/1000	87/7206	0.0274703564751
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1000	40/7206	0.0360560824704
ko05131	Shigellosis	5/1000	82/7206	0.0367220615112
ko03018	RNA degradation	5/1000	84/7206	0.0372798287014
ko05215	Prostate cancer	8/1000	111/7206	0.0378547875594
ko00330	Arginine and proline metabolism	3/1000	61/7206	0.039931594258
ko04622	RIG-I-like receptor signaling pathway	3/1000	62/7206	0.040344529229
ko04620	Toll-like receptor signaling pathway	7/1000	100/7206	0.0417181369625
ko05034	Alcoholism	44/1000	238/7206	0.0446065710674
ko05418	Fluid shear stress and atherosclerosis	15/1000	173/7206	0.0448318028945
ko04923	Regulation of lipolysis in adipocytes	17/1000	77/7206	0.0454079004932
ko05166	HTLV-I infection	29/1000	292/7206	0.0467308280605