ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	183/1013	423/7206	2.8736696236e-52
ko05033	Nicotine addiction	47/1013	56/7206	7.44716851785e-32
ko04724	Glutamatergic synapse	81/1013	152/7206	7.76219212534e-31
ko05032	Morphine addiction	61/1013	110/7206	1.11298356538e-24
ko04727	GABAergic synapse	60/1013	110/7206	8.80062425764e-24
ko04721	Synaptic vesicle cycle	50/1013	80/7206	1.09203518851e-23
ko04713	Circadian entrainment	64/1013	136/7206	9.49651961477e-21
ko04728	Dopaminergic synapse	77/1013	185/7206	1.14301239079e-20
ko04725	Cholinergic synapse	70/1013	160/7206	2.39892664481e-20
ko04723	Retrograde endocannabinoid signaling	72/1013	175/7206	4.78054493025e-19
ko04024	cAMP signaling pathway	92/1013	279/7206	1.96787772647e-16
ko04726	Serotonergic synapse	56/1013	137/7206	6.47811723081e-15
ko04742	Taste transduction	34/1013	61/7206	2.23872873585e-14
ko04921	Oxytocin signaling pathway	72/1013	209/7206	4.5539583218e-14
ko04911	Insulin secretion	48/1013	117/7206	4.94587550395e-13
ko04744	Phototransduction	24/1013	36/7206	6.40377899414e-13
ko04020	Calcium signaling pathway	81/1013	265/7206	1.69910414113e-12
ko05031	Amphetamine addiction	38/1013	91/7206	7.33114898738e-11
ko04720	Long-term potentiation	40/1013	99/7206	7.88223342064e-11
ko04261	Adrenergic signaling in cardiomyocytes	63/1013	205/7206	5.25680987095e-10
ko03040	Spliceosome	1/1013	145/7206	9.05259771058e-09
ko04360	Axon guidance	65/1013	233/7206	2.36602734133e-08
ko04060	Cytokine-cytokine receptor interaction	5/1013	191/7206	1.20368123545e-07
ko05203	Viral carcinogenesis	12/1013	277/7206	1.28600156851e-07
ko05030	Cocaine addiction	28/1013	73/7206	2.07351274346e-07
ko04966	Collecting duct acid secretion	15/1013	26/7206	2.53299351003e-07
ko04970	Salivary secretion	33/1013	95/7206	2.71934451055e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1013	74/7206	2.89564928583e-07
ko05168	Herpes simplex infection	6/1013	182/7206	2.14570452313e-06
ko04971	Gastric acid secretion	32/1013	98/7206	2.29122646044e-06
ko05322	Systemic lupus erythematosus	4/1013	151/7206	2.65840246944e-06
ko05110	Vibrio cholerae infection	23/1013	63/7206	6.75227661372e-06
ko04010	MAPK signaling pathway	74/1013	321/7206	1.10493727268e-05
ko04925	Aldosterone synthesis and secretion	32/1013	105/7206	1.22352689863e-05
ko04022	cGMP-PKG signaling pathway	54/1013	216/7206	1.47631007368e-05
ko04120	Ubiquitin mediated proteolysis	4/1013	138/7206	1.77313354295e-05
ko04745	Phototransduction - fly	16/1013	38/7206	2.18734977802e-05
ko04141	Protein processing in endoplasmic reticulum	8/1013	184/7206	2.20060215975e-05
ko04740	Olfactory transduction	26/1013	80/7206	2.46768219327e-05
ko04514	Cell adhesion molecules (CAMs)	36/1013	130/7206	3.54126759902e-05
ko05164	Influenza A	7/1013	167/7206	4.01107408664e-05
ko04730	Long-term depression	25/1013	78/7206	4.36798857338e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	25/1013	79/7206	5.26796657188e-05
ko04260	Cardiac muscle contraction	29/1013	98/7206	5.3974176512e-05
ko03013	RNA transport	7/1013	166/7206	5.88150911552e-05
ko04924	Renin secretion	26/1013	86/7206	0.000110028478211
ko04621	NOD-like receptor signaling pathway	7/1013	157/7206	0.000162553898661
ko04612	Antigen processing and presentation	1/1013	77/7206	0.000197041800471
ko00604	Glycosphingolipid biosynthesis - ganglio series	8/1013	14/7206	0.000202676807003
ko04350	TGF-beta signaling pathway	3/1013	103/7206	0.000274543359202
ko00310	Lysine degradation	1/1013	73/7206	0.000294469907747
ko04070	Phosphatidylinositol signaling system	30/1013	112/7206	0.000310906368427
ko04540	Gap junction	33/1013	128/7206	0.000428357793341
ko05169	Epstein-Barr virus infection	13/1013	206/7206	0.000513798684821
ko05162	Measles	5/1013	120/7206	0.000768957110805
ko04072	Phospholipase D signaling pathway	45/1013	197/7206	0.000788991950606
ko05414	Dilated cardiomyopathy	29/1013	112/7206	0.000835815772342
ko03008	Ribosome biogenesis in eukaryotes	2/1013	79/7206	0.000954713813166
ko04014	Ras signaling pathway	59/1013	279/7206	0.0010724057964
ko04915	Estrogen signaling pathway	32/1013	131/7206	0.00134011728682
ko04972	Pancreatic secretion	28/1013	111/7206	0.00142430662666
ko04750	Inflammatory mediator regulation of TRP channels	30/1013	122/7206	0.00151787963852
ko04110	Cell cycle	8/1013	145/7206	0.00153548883868
ko04626	Plant-pathogen interaction	8/1013	18/7206	0.001751487827
ko04146	Peroxisome	3/1013	89/7206	0.00176971819238
ko05161	Hepatitis B	11/1013	173/7206	0.00182370264327
ko05140	Leishmaniasis	2/1013	75/7206	0.00212976678863
ko03018	RNA degradation	3/1013	84/7206	0.00245406335029
ko04064	NF-kappa B signaling pathway	4/1013	96/7206	0.00274094654311
ko04932	Non-alcoholic fatty liver disease (NAFLD)	13/1013	182/7206	0.00477105126615
ko00480	Glutathione metabolism	1/1013	55/7206	0.00517284545956
ko00240	Pyrimidine metabolism	6/1013	110/7206	0.00551794207777
ko04640	Hematopoietic cell lineage	2/1013	64/7206	0.00631602527958
ko04961	Endocrine and other factor-regulated calcium reabsorption	16/1013	59/7206	0.00740673781967
ko00590	Arachidonic acid metabolism	1/1013	52/7206	0.00766092844084
ko04976	Bile secretion	20/1013	80/7206	0.00867175348785
ko05120	Epithelial cell signaling in Helicobacter pylori infection	22/1013	92/7206	0.00974579637684
ko05205	Proteoglycans in cancer	24/1013	271/7206	0.00974976421032
ko04214	Apoptosis - fly	3/1013	72/7206	0.0101403134658
ko00260	Glycine, serine and threonine metabolism	1/1013	48/7206	0.010986488904
ko00533	Glycosaminoglycan biosynthesis - keratan sulfate	6/1013	15/7206	0.012256862363
ko05410	Hypertrophic cardiomyopathy (HCM)	23/1013	100/7206	0.0134357953245
ko04964	Proximal tubule bicarbonate reclamation	9/1013	29/7206	0.014839055853
ko04630	Jak-STAT signaling pathway	9/1013	132/7206	0.0154956051186
ko05166	HTLV-I infection	27/1013	292/7206	0.015755773071
ko03022	Basal transcription factors	1/1013	44/7206	0.0161951622226
ko05144	Malaria	1/1013	45/7206	0.0162767618461
ko00071	Fatty acid degradation	1/1013	45/7206	0.0162767618461
ko00620	Pyruvate metabolism	1/1013	46/7206	0.0167489415285
ko03420	Nucleotide excision repair	1/1013	46/7206	0.0167489415285
ko05321	Inflammatory bowel disease (IBD)	2/1013	56/7206	0.0191427532931
ko04657	IL-17 signaling pathway	5/1013	87/7206	0.019813340732
ko05418	Fluid shear stress and atherosclerosis	14/1013	173/7206	0.0198331459452
ko04371	Apelin signaling pathway	36/1013	177/7206	0.0208225174613
ko04140	Autophagy - animal	13/1013	164/7206	0.0223425011954
ko04912	GnRH signaling pathway	26/1013	122/7206	0.0251263482476
ko05202	Transcriptional misregulation in cancer	16/1013	188/7206	0.0252147343842
ko05145	Toxoplasmosis	9/1013	126/7206	0.0267763450386
ko00280	Valine, leucine and isoleucine degradation	2/1013	54/7206	0.0280898223375
ko00600	Sphingolipid metabolism	3/1013	63/7206	0.0283994802205
ko01524	Platinum drug resistance	4/1013	76/7206	0.0290126575044
ko05323	Rheumatoid arthritis	20/1013	89/7206	0.030241544849
ko04668	TNF signaling pathway	9/1013	120/7206	0.0340649392505
ko00630	Glyoxylate and dicarboxylate metabolism	1/1013	38/7206	0.0354433621671
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1013	40/7206	0.0364107390281
ko05131	Shigellosis	5/1013	82/7206	0.0366525699673
ko01200	Carbon metabolism	10/1013	128/7206	0.0396217481257
ko04330	Notch signaling pathway	3/1013	62/7206	0.0408580385551
ko04622	RIG-I-like receptor signaling pathway	3/1013	62/7206	0.0408580385551
ko05146	Amoebiasis	7/1013	99/7206	0.0414925514248
ko04015	Rap1 signaling pathway	51/1013	278/7206	0.0425140333405
ko05231	Choline metabolism in cancer	27/1013	134/7206	0.0448333005454
ko05222	Small cell lung cancer	6/1013	89/7206	0.0454381487922
ko04923	Regulation of lipolysis in adipocytes	17/1013	77/7206	0.047844171952