ko pathway ratio_in_study ratio_in_pop p_value ko00120 Primary bile acid biosynthesis 11/483 20/7206 1.06025205607e-08 ko04380 Osteoclast differentiation 28/483 134/7206 4.50156826644e-08 ko00350 Tyrosine metabolism 11/483 33/7206 5.47929727265e-06 ko05164 Influenza A 27/483 167/7206 2.28220034707e-05 ko04060 Cytokine-cytokine receptor interaction 29/483 191/7206 2.59988370644e-05 ko04064 NF-kappa B signaling pathway 18/483 96/7206 5.53776392509e-05 ko04621 NOD-like receptor signaling pathway 25/483 157/7206 5.61887831005e-05 ko05150 Staphylococcus aureus infection 10/483 36/7206 8.66806023487e-05 ko05034 Alcoholism 3/483 238/7206 0.00010080070701 ko05140 Leishmaniasis 15/483 75/7206 0.000107285084351 ko03013 RNA transport 1/483 166/7206 0.000216457194199 ko04146 Peroxisome 16/483 89/7206 0.00023742196945 ko04630 Jak-STAT signaling pathway 21/483 132/7206 0.000262304079544 ko05145 Toxoplasmosis 20/483 126/7206 0.000391024233109 ko00360 Phenylalanine metabolism 6/483 17/7206 0.000575269845615 ko04672 Intestinal immune network for IgA production 9/483 37/7206 0.000580188274415 ko05144 Malaria 10/483 45/7206 0.000630023890209 ko04137 Mitophagy - animal 14/483 82/7206 0.000981886036963 ko00643 Styrene degradation 3/483 4/7206 0.00113770695975 ko04668 TNF signaling pathway 18/483 120/7206 0.00120587053641 ko05162 Measles 18/483 120/7206 0.00120587053641 ko04390 Hippo signaling pathway 3/483 188/7206 0.00171130925456 ko04610 Complement and coagulation cascades 13/483 79/7206 0.00208356048617 ko04659 Th17 cell differentiation 16/483 106/7206 0.00232968814705 ko04622 RIG-I-like receptor signaling pathway 11/483 62/7206 0.0024473360845 ko04620 Toll-like receptor signaling pathway 15/483 100/7206 0.00345488580952 ko05321 Inflammatory bowel disease (IBD) 10/483 56/7206 0.0036223204498 ko05152 Tuberculosis 23/483 187/7206 0.00431468367929 ko00130 Ubiquinone and other terpenoid-quinone biosynthesis 4/483 11/7206 0.00450224544885 ko05224 Breast cancer 3/483 174/7206 0.00497906584773 ko00362 Benzoate degradation 3/483 6/7206 0.00513689279025 ko04623 Cytosolic DNA-sensing pathway 8/483 41/7206 0.00513987353394 ko04660 T cell receptor signaling pathway 17/483 124/7206 0.00529618536935 ko03320 PPAR signaling pathway 11/483 69/7206 0.00575098166826 ko00051 Fructose and mannose metabolism 8/483 42/7206 0.00598667384334 ko04650 Natural killer cell mediated cytotoxicity 14/483 97/7206 0.0061045427319 ko04932 Non-alcoholic fatty liver disease (NAFLD) 22/483 182/7206 0.00628780459799 ko05132 Salmonella infection 14/483 98/7206 0.00651018098894 ko04710 Circadian rhythm 8/483 43/7206 0.00693545898075 ko04360 Axon guidance 6/483 233/7206 0.00722482447313 ko04662 B cell receptor signaling pathway 13/483 88/7206 0.00761325298792 ko05323 Rheumatoid arthritis 13/483 89/7206 0.00802388233239 ko00071 Fatty acid degradation 8/483 45/7206 0.00916843134715 ko04640 Hematopoietic cell lineage 10/483 64/7206 0.00954322251066 ko00982 Drug metabolism - cytochrome P450 7/483 37/7206 0.0103130047682 ko04068 FoxO signaling pathway 20/483 167/7206 0.0110476807291 ko04540 Gap junction 2/483 128/7206 0.0118828379084 ko04658 Th1 and Th2 cell differentiation 13/483 96/7206 0.0125154291555 ko05340 Primary immunodeficiency 6/483 30/7206 0.0131264928968 ko04723 Retrograde endocannabinoid signaling 4/483 175/7206 0.0135033043184 ko05168 Herpes simplex infection 21/483 182/7206 0.0149363822432 ko05133 Pertussis 12/483 87/7206 0.0150299962282 ko05134 Legionellosis 11/483 74/7206 0.0154875706419 ko04611 Platelet activation 19/483 163/7206 0.0164004757395 ko00380 Tryptophan metabolism 8/483 50/7206 0.0170509329845 ko03040 Spliceosome 3/483 145/7206 0.0180890284928 ko04110 Cell cycle 3/483 145/7206 0.0180890284928 ko04210 Apoptosis 20/483 180/7206 0.0227432253735 ko05131 Shigellosis 11/483 82/7206 0.0234962986609 ko05310 Asthma 4/483 17/7206 0.0235666928721 ko04728 Dopaminergic synapse 5/483 185/7206 0.0244042325091 ko00960 Tropane, piperidine and pyridine alkaloid biosynthesis 2/483 4/7206 0.0245687529738 ko00950 Isoquinoline alkaloid biosynthesis 3/483 10/7206 0.0251891493092 ko04916 Melanogenesis 3/483 142/7206 0.0255673642731 ko04550 Signaling pathways regulating pluripotency of stem cells 4/483 165/7206 0.0256552405353 ko00500 Starch and sucrose metabolism 6/483 35/7206 0.0270686933586 ko01200 Carbon metabolism 15/483 128/7206 0.0306114520763 ko00710 Carbon fixation in photosynthetic organisms 5/483 27/7206 0.0313432625894 ko05160 Hepatitis C 17/483 153/7206 0.0334413435596 ko00592 alpha-Linolenic acid metabolism 4/483 19/7206 0.0345305956388 ko04612 Antigen processing and presentation 10/483 77/7206 0.0365849496826 ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis 2/483 5/7206 0.0391461907468 ko05204 Chemical carcinogenesis 7/483 48/7206 0.0392619025012 ko04666 Fc gamma R-mediated phagocytosis 14/483 122/7206 0.0427642084698 ko02010 ABC transporters 6/483 39/7206 0.0434996920367 ko04217 Necroptosis 19/483 178/7206 0.0461585605516 ko05322 Systemic lupus erythematosus 4/483 151/7206 0.0463582535819 ko04724 Glutamatergic synapse 4/483 152/7206 0.0467441760044 ko04350 TGF-beta signaling pathway 2/483 103/7206 0.0467990087681