ko pathway ratio_in_study ratio_in_pop p_value ko04060 Cytokine-cytokine receptor interaction 44/357 191/7206 1.69336771681e-18 ko04380 Osteoclast differentiation 32/357 134/7206 3.50240382625e-14 ko05321 Inflammatory bowel disease (IBD) 20/357 56/7206 7.17872108626e-13 ko05340 Primary immunodeficiency 15/357 30/7206 1.56708320731e-12 ko05168 Herpes simplex infection 34/357 182/7206 1.01285165306e-11 ko05164 Influenza A 32/357 167/7206 2.1117888062e-11 ko05145 Toxoplasmosis 27/357 126/7206 5.75032772755e-11 ko04621 NOD-like receptor signaling pathway 30/357 157/7206 9.93934405457e-11 ko04650 Natural killer cell mediated cytotoxicity 23/357 97/7206 1.85740271299e-10 ko05330 Allograft rejection 12/357 24/7206 2.87588519701e-10 ko05140 Leishmaniasis 20/357 75/7206 3.07860053621e-10 ko05162 Measles 25/357 120/7206 5.73145278212e-10 ko05150 Staphylococcus aureus infection 14/357 36/7206 5.85750001877e-10 ko04630 Jak-STAT signaling pathway 26/357 132/7206 9.33493345922e-10 ko05152 Tuberculosis 31/357 187/7206 1.94198125714e-09 ko04064 NF-kappa B signaling pathway 21/357 96/7206 5.6388897972e-09 ko04612 Antigen processing and presentation 18/357 77/7206 2.3563163036e-08 ko04658 Th1 and Th2 cell differentiation 20/357 96/7206 3.17242603457e-08 ko04659 Th17 cell differentiation 21/357 106/7206 3.63341763954e-08 ko04217 Necroptosis 28/357 178/7206 3.97737867087e-08 ko05332 Graft-versus-host disease 9/357 18/7206 5.32033253001e-08 ko04620 Toll-like receptor signaling pathway 19/357 100/7206 3.28845275408e-07 ko04640 Hematopoietic cell lineage 15/357 64/7206 3.42984283001e-07 ko05310 Asthma 8/357 17/7206 5.5091304323e-07 ko04660 T cell receptor signaling pathway 21/357 124/7206 5.96327732116e-07 ko05320 Autoimmune thyroid disease 10/357 29/7206 6.75963739163e-07 ko04672 Intestinal immune network for IgA production 11/357 37/7206 1.01098182925e-06 ko05167 Kaposi's sarcoma-associated herpesvirus infection 25/357 191/7206 7.06409418574e-06 ko05144 Malaria 11/357 45/7206 8.38909058089e-06 ko04940 Type I diabetes mellitus 9/357 32/7206 1.65219536972e-05 ko05160 Hepatitis C 21/357 153/7206 1.86931844132e-05 ko05133 Pertussis 15/357 87/7206 1.99345212503e-05 ko04662 B cell receptor signaling pathway 15/357 88/7206 2.29664640377e-05 ko05323 Rheumatoid arthritis 15/357 89/7206 2.63987808526e-05 ko04610 Complement and coagulation cascades 14/357 79/7206 2.73513106428e-05 ko05161 Hepatitis B 21/357 173/7206 0.000117740346085 ko04145 Phagosome 20/357 162/7206 0.000135162439964 ko04611 Platelet activation 20/357 163/7206 0.000147202569143 ko04622 RIG-I-like receptor signaling pathway 11/357 62/7206 0.000196771787595 ko05142 Chagas disease (American trypanosomiasis) 17/357 130/7206 0.000213356526037 ko04668 TNF signaling pathway 16/357 120/7206 0.000260176124115 ko04062 Chemokine signaling pathway 22/357 201/7206 0.000399248443969 ko05034 Alcoholism 2/357 238/7206 0.000717140332883 ko05146 Amoebiasis 13/357 99/7206 0.0011211926594 ko04664 Fc epsilon RI signaling pathway 11/357 77/7206 0.00132952175608 ko05169 Epstein-Barr virus infection 21/357 206/7206 0.00155640919071 ko04310 Wnt signaling pathway 1/357 181/7206 0.00155844762094 ko04728 Dopaminergic synapse 1/357 185/7206 0.00158630609247 ko04666 Fc gamma R-mediated phagocytosis 14/357 122/7206 0.00271898847503 ko05132 Salmonella infection 12/357 98/7206 0.00313443834385 ko04657 IL-17 signaling pathway 11/357 87/7206 0.00358315436036 ko00140 Steroid hormone biosynthesis 7/357 41/7206 0.00360846555247 ko00590 Arachidonic acid metabolism 8/357 52/7206 0.00372575330392 ko05143 African trypanosomiasis 6/357 32/7206 0.0042944417153 ko04210 Apoptosis 18/357 180/7206 0.00440676654985 ko05416 Viral myocarditis 8/357 55/7206 0.00529937130909 ko04390 Hippo signaling pathway 2/357 188/7206 0.00921745391558 ko04916 Melanogenesis 1/357 142/7206 0.0101903953003 ko03040 Spliceosome 1/357 145/7206 0.0103819614723 ko04072 Phospholipase D signaling pathway 18/357 197/7206 0.0112789343706 ko04670 Leukocyte transendothelial migration 15/357 151/7206 0.0115271030072 ko04723 Retrograde endocannabinoid signaling 2/357 175/7206 0.0124560826296 ko00592 alpha-Linolenic acid metabolism 4/357 19/7206 0.0127003294951 ko05166 HTLV-I infection 24/357 292/7206 0.012774620351 ko04514 Cell adhesion molecules (CAMs) 13/357 130/7206 0.0132151333196 ko04623 Cytosolic DNA-sensing pathway 6/357 41/7206 0.0146680242638 ko00120 Primary bile acid biosynthesis 4/357 20/7206 0.0152687700774 ko05418 Fluid shear stress and atherosclerosis 16/357 173/7206 0.0187877365422 ko03010 Ribosome 1/357 129/7206 0.0217561429166 ko05016 Huntington's disease 4/357 215/7206 0.035818029757 ko04727 GABAergic synapse 1/357 110/7206 0.0443254806235 ko00601 Glycosphingolipid biosynthesis - lacto and neolacto series 4/357 28/7206 0.0473758599087 ko03050 Proteasome 6/357 54/7206 0.0494668430473