ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	172/1095	423/7206	1.49036739289e-39
ko04724	Glutamatergic synapse	84/1095	152/7206	5.98101185106e-31
ko05033	Nicotine addiction	46/1095	56/7206	7.6645587432e-29
ko05032	Morphine addiction	65/1095	110/7206	2.00215465321e-26
ko04727	GABAergic synapse	64/1095	110/7206	1.67303127137e-25
ko04721	Synaptic vesicle cycle	50/1095	80/7206	3.9751841543e-22
ko04713	Circadian entrainment	67/1095	136/7206	3.80286145466e-21
ko04728	Dopaminergic synapse	79/1095	185/7206	7.35201672953e-20
ko04723	Retrograde endocannabinoid signaling	76/1095	175/7206	1.13958571676e-19
ko04725	Cholinergic synapse	69/1095	160/7206	9.35659791816e-18
ko04744	Phototransduction	27/1095	36/7206	1.43231225752e-15
ko04742	Taste transduction	36/1095	61/7206	3.86493554733e-15
ko04024	cAMP signaling pathway	94/1095	279/7206	4.44876818865e-15
ko04911	Insulin secretion	48/1095	117/7206	9.22053201652e-12
ko04726	Serotonergic synapse	53/1095	137/7206	1.15345289854e-11
ko04921	Oxytocin signaling pathway	70/1095	209/7206	2.40565810654e-11
ko04261	Adrenergic signaling in cardiomyocytes	69/1095	205/7206	3.116305731e-11
ko04020	Calcium signaling pathway	82/1095	265/7206	3.95072219448e-11
ko03040	Spliceosome	1/1095	145/7206	1.36060424821e-09
ko05031	Amphetamine addiction	36/1095	91/7206	1.20080740792e-08
ko04970	Salivary secretion	37/1095	95/7206	1.24097511555e-08
ko05203	Viral carcinogenesis	13/1095	277/7206	2.96884877322e-08
ko04720	Long-term potentiation	37/1095	99/7206	4.50600291442e-08
ko04360	Axon guidance	66/1095	233/7206	2.07467039662e-07
ko05322	Systemic lupus erythematosus	4/1095	151/7206	4.96883268156e-07
ko04120	Ubiquitin mediated proteolysis	3/1095	138/7206	4.97967736147e-07
ko04966	Collecting duct acid secretion	15/1095	26/7206	7.16873064636e-07
ko04060	Cytokine-cytokine receptor interaction	8/1095	191/7206	1.74423304242e-06
ko05164	Influenza A	6/1095	167/7206	1.7957265646e-06
ko03013	RNA transport	6/1095	166/7206	2.74297605047e-06
ko05030	Cocaine addiction	27/1095	73/7206	3.76542090827e-06
ko05168	Herpes simplex infection	8/1095	182/7206	4.9612965172e-06
ko04971	Gastric acid secretion	33/1095	98/7206	5.28254514588e-06
ko04925	Aldosterone synthesis and secretion	34/1095	105/7206	7.53430703315e-06
ko04022	cGMP-PKG signaling pathway	57/1095	216/7206	1.78871719149e-05
ko05205	Proteoglycans in cancer	18/1095	271/7206	1.97521350761e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1095	79/7206	2.25060680875e-05
ko04621	NOD-like receptor signaling pathway	7/1095	157/7206	2.56417818676e-05
ko04740	Olfactory transduction	27/1095	80/7206	2.82207349244e-05
ko04141	Protein processing in endoplasmic reticulum	10/1095	184/7206	4.26854012488e-05
ko05169	Epstein-Barr virus infection	12/1095	206/7206	4.39887981324e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	25/1095	74/7206	5.5999479293e-05
ko04972	Pancreatic secretion	33/1095	111/7206	8.25461124369e-05
ko04260	Cardiac muscle contraction	30/1095	98/7206	9.39100640277e-05
ko05414	Dilated cardiomyopathy	33/1095	112/7206	9.50362862606e-05
ko04514	Cell adhesion molecules (CAMs)	37/1095	130/7206	9.9696357681e-05
ko04924	Renin secretion	27/1095	86/7206	0.00012077985025
ko04540	Gap junction	36/1095	128/7206	0.000152771141392
ko04010	MAPK signaling pathway	74/1095	321/7206	0.000167757465382
ko04064	NF-kappa B signaling pathway	3/1095	96/7206	0.000257244776696
ko04070	Phosphatidylinositol signaling system	32/1095	112/7206	0.000266502942747
ko05110	Vibrio cholerae infection	21/1095	63/7206	0.000278404554034
ko00604	Glycosphingolipid biosynthesis - ganglio series	8/1095	14/7206	0.000353322255202
ko04730	Long-term depression	24/1095	78/7206	0.000403034309443
ko03008	Ribosome biogenesis in eukaryotes	2/1095	79/7206	0.000409376456504
ko05161	Hepatitis B	11/1095	173/7206	0.000530526572458
ko05162	Measles	6/1095	120/7206	0.000737645605654
ko04976	Bile secretion	24/1095	80/7206	0.000761797920145
ko05140	Leishmaniasis	2/1095	75/7206	0.000930885531186
ko05145	Toxoplasmosis	7/1095	126/7206	0.00104858999785
ko04072	Phospholipase D signaling pathway	47/1095	197/7206	0.00118490270306
ko00480	Glutathione metabolism	1/1095	55/7206	0.00208649618609
ko04964	Proximal tubule bicarbonate reclamation	11/1095	29/7206	0.00234220642188
ko04146	Peroxisome	4/1095	89/7206	0.00258778468087
ko04140	Autophagy - animal	12/1095	164/7206	0.0028421309669
ko00240	Pyrimidine metabolism	6/1095	110/7206	0.00285151443726
ko04915	Estrogen signaling pathway	33/1095	131/7206	0.00287678640947
ko00590	Arachidonic acid metabolism	1/1095	52/7206	0.0031201765101
ko04932	Non-alcoholic fatty liver disease (NAFLD)	14/1095	182/7206	0.00319738521488
ko04110	Cell cycle	10/1095	145/7206	0.00326789701737
ko01524	Platinum drug resistance	3/1095	76/7206	0.00334390963197
ko04612	Antigen processing and presentation	3/1095	77/7206	0.00344593551118
ko04014	Ras signaling pathway	60/1095	279/7206	0.00377997290483
ko04371	Apelin signaling pathway	41/1095	177/7206	0.00412186790958
ko04640	Hematopoietic cell lineage	2/1095	64/7206	0.00427811037405
ko05410	Hypertrophic cardiomyopathy (HCM)	26/1095	100/7206	0.00457885533356
ko04630	Jak-STAT signaling pathway	9/1095	132/7206	0.00464182782633
ko04745	Phototransduction - fly	13/1095	38/7206	0.00471601065994
ko04214	Apoptosis - fly	3/1095	72/7206	0.0047617193573
ko00310	Lysine degradation	3/1095	73/7206	0.0047753099368
ko03018	RNA degradation	4/1095	84/7206	0.00524083708877
ko03420	Nucleotide excision repair	1/1095	46/7206	0.00700496917437
ko00260	Glycine, serine and threonine metabolism	1/1095	48/7206	0.00723416628849
ko04961	Endocrine and other factor-regulated calcium reabsorption	17/1095	59/7206	0.00927903823748
ko03022	Basal transcription factors	1/1095	44/7206	0.0104277586195
ko05144	Malaria	1/1095	45/7206	0.0106618677997
ko00071	Fatty acid degradation	1/1095	45/7206	0.0106618677997
ko04217	Necroptosis	15/1095	178/7206	0.0106864188661
ko00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	9/1095	26/7206	0.0113753585857
ko05120	Epithelial cell signaling in Helicobacter pylori infection	23/1095	92/7206	0.0123923106333
ko05321	Inflammatory bowel disease (IBD)	2/1095	56/7206	0.0132804491977
ko04668	TNF signaling pathway	9/1095	120/7206	0.0145824650069
ko04923	Regulation of lipolysis in adipocytes	20/1095	77/7206	0.0152074541011
ko04210	Apoptosis	16/1095	180/7206	0.0152634076862
ko05215	Prostate cancer	8/1095	111/7206	0.0158623695494
ko04620	Toll-like receptor signaling pathway	7/1095	100/7206	0.0170633888542
ko05131	Shigellosis	5/1095	82/7206	0.0192081286384
ko05206	MicroRNAs in cancer	16/1095	177/7206	0.0193366764369
ko00330	Arginine and proline metabolism	3/1095	61/7206	0.0194578801122
ko04622	RIG-I-like receptor signaling pathway	3/1095	62/7206	0.0195842940682
ko00561	Glycerolipid metabolism	3/1095	63/7206	0.0200680772916
ko04750	Inflammatory mediator regulation of TRP channels	28/1095	122/7206	0.0214177931505
ko00630	Glyoxylate and dicarboxylate metabolism	1/1095	38/7206	0.0230994668559
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1095	40/7206	0.0240186803047
ko05418	Fluid shear stress and atherosclerosis	16/1095	173/7206	0.0244045382734
ko05222	Small cell lung cancer	6/1095	89/7206	0.0247100936808
ko05219	Bladder cancer	2/1095	48/7206	0.0264287118101
ko00380	Tryptophan metabolism	2/1095	50/7206	0.0271314390381
ko03320	PPAR signaling pathway	4/1095	69/7206	0.0272373425126
ko04658	Th1 and Th2 cell differentiation	7/1095	96/7206	0.0306269149035
ko04657	IL-17 signaling pathway	6/1095	87/7206	0.0337507805143
ko05133	Pertussis	6/1095	87/7206	0.0337507805143
ko01200	Carbon metabolism	11/1095	128/7206	0.034362479141
ko00982	Drug metabolism - cytochrome P450	1/1095	37/7206	0.0352048846221
ko05166	HTLV-I infection	32/1095	292/7206	0.0376155059113
ko00620	Pyruvate metabolism	2/1095	46/7206	0.0379835381787
ko00270	Cysteine and methionine metabolism	2/1095	47/7206	0.0386875117973
ko04933	AGE-RAGE signaling pathway in diabetic complications	12/1095	135/7206	0.039189882301
ko04626	Plant-pathogen interaction	6/1095	18/7206	0.0440854261116
ko04137	Mitophagy - animal	6/1095	82/7206	0.0440924211248
ko04918	Thyroid hormone synthesis	20/1095	86/7206	0.0477774766655
ko04115	p53 signaling pathway	5/1095	74/7206	0.0487324288731