ko pathway ratio_in_study ratio_in_pop p_value ko00120 Primary bile acid biosynthesis 10/296 20/7206 1.50960289231e-09 ko01200 Carbon metabolism 19/296 128/7206 9.68122337326e-07 ko04974 Protein digestion and absorption 16/296 96/7206 1.47963975143e-06 ko00380 Tryptophan metabolism 11/296 50/7206 4.15897015945e-06 ko00071 Fatty acid degradation 10/296 45/7206 1.04325105897e-05 ko00620 Pyruvate metabolism 10/296 46/7206 1.28524709546e-05 ko04610 Complement and coagulation cascades 13/296 79/7206 1.67178160088e-05 ko00360 Phenylalanine metabolism 6/296 17/7206 3.85148092924e-05 ko00362 Benzoate degradation 4/296 6/7206 3.92087637653e-05 ko00190 Oxidative phosphorylation 16/296 127/7206 5.75595887868e-05 ko04976 Bile secretion 12/296 80/7206 9.06533295929e-05 ko04964 Proximal tubule bicarbonate reclamation 7/296 29/7206 0.000131480278524 ko04146 Peroxisome 12/296 89/7206 0.000256649701944 ko00350 Tyrosine metabolism 7/296 33/7206 0.000312451330742 ko00640 Propanoate metabolism 7/296 34/7206 0.000379818747491 ko03320 PPAR signaling pathway 10/296 69/7206 0.000464239936636 ko04972 Pancreatic secretion 13/296 111/7206 0.000584601355446 ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis 3/296 5/7206 0.000645170688797 ko01230 Biosynthesis of amino acids 11/296 85/7206 0.000659787959124 ko05204 Chemical carcinogenesis 8/296 48/7206 0.000662817945127 ko00010 Glycolysis / Gluconeogenesis 10/296 74/7206 0.000818298409965 ko05134 Legionellosis 10/296 74/7206 0.000818298409965 ko00980 Metabolism of xenobiotics by cytochrome P450 7/296 40/7206 0.00106565820861 ko00140 Steroid hormone biosynthesis 7/296 41/7206 0.0012406978671 ko00830 Retinol metabolism 7/296 42/7206 0.00143747378319 ko04151 PI3K-Akt signaling pathway 5/296 390/7206 0.00153405340957 ko00020 Citrate cycle (TCA cycle) 6/296 35/7206 0.00270683656666 ko00270 Cysteine and methionine metabolism 7/296 47/7206 0.00281245240849 ko04144 Endocytosis 4/296 342/7206 0.00291629297671 ko00260 Glycine, serine and threonine metabolism 7/296 48/7206 0.00317946317056 ko00982 Drug metabolism - cytochrome P450 6/296 37/7206 0.0036191994752 ko00630 Glyoxylate and dicarboxylate metabolism 6/296 38/7206 0.0041526883667 ko00710 Carbon fixation in photosynthetic organisms 5/296 27/7206 0.00433337768109 ko05034 Alcoholism 2/296 238/7206 0.00439018245162 ko04978 Mineral absorption 6/296 40/7206 0.00539094852837 ko04614 Renin-angiotensin system 4/296 18/7206 0.00540642014277 ko05012 Parkinson's disease 14/296 155/7206 0.00589179578122 ko04922 Glucagon signaling pathway 12/296 128/7206 0.00617476304314 ko00280 Valine, leucine and isoleucine degradation 7/296 54/7206 0.00620305423001 ko00130 Ubiquinone and other terpenoid-quinone biosynthesis 3/296 11/7206 0.00885460031868 ko00960 Tropane, piperidine and pyridine alkaloid biosynthesis 2/296 4/7206 0.00955033767268 ko00643 Styrene degradation 2/296 4/7206 0.00955033767268 ko01212 Fatty acid metabolism 7/296 60/7206 0.0109816152781 ko00053 Ascorbate and aldarate metabolism 4/296 22/7206 0.0113592932104 ko04932 Non-alcoholic fatty liver disease (NAFLD) 15/296 182/7206 0.011688497946 ko00330 Arginine and proline metabolism 7/296 61/7206 0.0119825859322 ko04975 Fat digestion and absorption 5/296 35/7206 0.0133405156646 ko05150 Staphylococcus aureus infection 5/296 36/7206 0.0149860258559 ko00220 Arginine biosynthesis 4/296 24/7206 0.0154742213326 ko00281 Geraniol degradation 2/296 5/7206 0.0154871156621 ko04015 Rap1 signaling pathway 4/296 278/7206 0.0193921943649 ko04014 Ras signaling pathway 4/296 279/7206 0.0195083253178 ko00040 Pentose and glucuronate interconversions 4/296 26/7206 0.020420628525 ko04966 Collecting duct acid secretion 4/296 26/7206 0.020420628525 ko02010 ABC transporters 5/296 39/7206 0.0207212043215 ko04724 Glutamatergic synapse 1/296 152/7206 0.021672718359 ko00480 Glutathione metabolism 6/296 55/7206 0.0244327453045 ko04390 Hippo signaling pathway 2/296 188/7206 0.0249275687225 ko05133 Pertussis 8/296 87/7206 0.0259513417693 ko00983 Drug metabolism - other enzymes 5/296 42/7206 0.027727676089 ko05010 Alzheimer's disease 15/296 202/7206 0.0280022185878 ko00310 Lysine degradation 7/296 73/7206 0.029585655629 ko00720 Carbon fixation pathways in prokaryotes 3/296 17/7206 0.0304253484142 ko04080 Neuroactive ligand-receptor interaction 9/296 423/7206 0.0313930492126 ko04110 Cell cycle 1/296 145/7206 0.031630413463 ko05200 Pathways in cancer 11/296 492/7206 0.0330282996292 ko04310 Wnt signaling pathway 2/296 181/7206 0.0351052836717 ko00592 alpha-Linolenic acid metabolism 3/296 19/7206 0.0408289309308 ko00910 Nitrogen metabolism 3/296 19/7206 0.0408289309308 ko00401 Novobiocin biosynthesis 1/296 1/7206 0.0410768803776 ko04726 Serotonergic synapse 1/296 137/7206 0.0461088767126 ko00680 Methane metabolism 4/296 34/7206 0.0491329384605 ko05224 Breast cancer 2/296 174/7206 0.0497917954937