ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	213/1245	423/7206	6.16336471699e-59
ko04724	Glutamatergic synapse	91/1245	152/7206	1.05925125376e-32
ko05033	Nicotine addiction	49/1245	56/7206	1.29771496261e-30
ko05032	Morphine addiction	70/1245	110/7206	1.09137998036e-27
ko04713	Circadian entrainment	78/1245	136/7206	2.07572817329e-26
ko04727	GABAergic synapse	67/1245	110/7206	6.25790096669e-25
ko04721	Synaptic vesicle cycle	52/1245	80/7206	1.77453544299e-21
ko04020	Calcium signaling pathway	109/1245	265/7206	1.20875322737e-20
ko04024	cAMP signaling pathway	112/1245	279/7206	3.16886543405e-20
ko04728	Dopaminergic synapse	85/1245	185/7206	4.50216814633e-20
ko04725	Cholinergic synapse	77/1245	160/7206	8.85631437882e-20
ko04723	Retrograde endocannabinoid signaling	78/1245	175/7206	1.51744651894e-17
ko04742	Taste transduction	39/1245	61/7206	4.76373578965e-16
ko04911	Insulin secretion	57/1245	117/7206	3.02903212782e-15
ko04726	Serotonergic synapse	62/1245	137/7206	1.45094754168e-14
ko04744	Phototransduction	27/1245	36/7206	3.85101432095e-14
ko04921	Oxytocin signaling pathway	81/1245	209/7206	6.30590815091e-14
ko04261	Adrenergic signaling in cardiomyocytes	76/1245	205/7206	6.33028105751e-12
ko04970	Salivary secretion	45/1245	95/7206	9.09803171641e-12
ko03040	Spliceosome	1/1245	145/7206	4.30710614507e-11
ko04720	Long-term potentiation	45/1245	99/7206	5.28748903992e-11
ko05031	Amphetamine addiction	42/1245	91/7206	1.28190560485e-10
ko04740	Olfactory transduction	38/1245	80/7206	3.46282315252e-10
ko05203	Viral carcinogenesis	15/1245	277/7206	3.07093412788e-09
ko04022	cGMP-PKG signaling pathway	70/1245	216/7206	3.96662875507e-08
ko05168	Herpes simplex infection	7/1245	182/7206	4.11778893673e-08
ko04360	Axon guidance	74/1245	233/7206	4.55393276651e-08
ko05030	Cocaine addiction	32/1245	73/7206	9.48618172368e-08
ko04971	Gastric acid secretion	39/1245	98/7206	1.02470976186e-07
ko04925	Aldosterone synthesis and secretion	41/1245	105/7206	1.28350737375e-07
ko04060	Cytokine-cytokine receptor interaction	9/1245	191/7206	1.72956549739e-07
ko03013	RNA transport	7/1245	166/7206	3.78417573736e-07
ko05322	Systemic lupus erythematosus	6/1245	151/7206	9.96270970537e-07
ko05164	Influenza A	8/1245	167/7206	1.33577611457e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	30/1245	74/7206	2.55374169891e-06
ko04966	Collecting duct acid secretion	15/1245	26/7206	3.87026033663e-06
ko04540	Gap junction	43/1245	128/7206	8.08672364281e-06
ko04972	Pancreatic secretion	38/1245	111/7206	1.19831737349e-05
ko04010	MAPK signaling pathway	85/1245	321/7206	2.13911319077e-05
ko04621	NOD-like receptor signaling pathway	9/1245	157/7206	2.43907838387e-05
ko04110	Cell cycle	8/1245	145/7206	3.22941850337e-05
ko04976	Bile secretion	29/1245	80/7206	3.88363402829e-05
ko04070	Phosphatidylinositol signaling system	37/1245	112/7206	4.1227660376e-05
ko04730	Long-term depression	28/1245	78/7206	6.36658514262e-05
ko04610	Complement and coagulation cascades	2/1245	79/7206	7.05350006167e-05
ko03008	Ribosome biogenesis in eukaryotes	2/1245	79/7206	7.05350006167e-05
ko04924	Renin secretion	30/1245	86/7206	7.25447303826e-05
ko04120	Ubiquitin mediated proteolysis	8/1245	138/7206	9.05230421784e-05
ko05169	Epstein-Barr virus infection	16/1245	206/7206	0.000108685737925
ko04371	Apelin signaling pathway	51/1245	177/7206	0.000113038451343
ko05414	Dilated cardiomyopathy	36/1245	112/7206	0.000118288661195
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	28/1245	79/7206	0.000118996074812
ko04514	Cell adhesion molecules (CAMs)	40/1245	130/7206	0.000143584686971
ko05140	Leishmaniasis	2/1245	75/7206	0.000159703681622
ko04064	NF-kappa B signaling pathway	4/1245	96/7206	0.00018243870824
ko04961	Endocrine and other factor-regulated calcium reabsorption	22/1245	59/7206	0.000200025700131
ko05205	Proteoglycans in cancer	25/1245	271/7206	0.000206677297626
ko04260	Cardiac muscle contraction	32/1245	98/7206	0.000210331680433
ko04141	Protein processing in endoplasmic reticulum	14/1245	184/7206	0.000222479492588
ko04745	Phototransduction - fly	16/1245	38/7206	0.000280720160093
ko05110	Vibrio cholerae infection	23/1245	63/7206	0.000281600003435
ko04072	Phospholipase D signaling pathway	54/1245	197/7206	0.000360925669241
ko04750	Inflammatory mediator regulation of TRP channels	37/1245	122/7206	0.000379877924713
ko04923	Regulation of lipolysis in adipocytes	26/1245	77/7206	0.000388598903786
ko04014	Ras signaling pathway	71/1245	279/7206	0.00047806842061
ko04612	Antigen processing and presentation	3/1245	77/7206	0.00067647619949
ko05161	Hepatitis B	14/1245	173/7206	0.000706400389632
ko05162	Measles	8/1245	120/7206	0.000918915541003
ko04915	Estrogen signaling pathway	38/1245	131/7206	0.000949779480438
ko04640	Hematopoietic cell lineage	2/1245	64/7206	0.00122423790511
ko00240	Pyrimidine metabolism	7/1245	110/7206	0.00129745877515
ko04626	Plant-pathogen interaction	9/1245	18/7206	0.00145434999321
ko04146	Peroxisome	5/1245	89/7206	0.00171123476791
ko00330	Arginine and proline metabolism	2/1245	61/7206	0.00175005648352
ko04964	Proximal tubule bicarbonate reclamation	12/1245	29/7206	0.00193547843525
ko03420	Nucleotide excision repair	1/1245	46/7206	0.00279162237479
ko00480	Glutathione metabolism	2/1245	55/7206	0.00369763301483
ko05321	Inflammatory bowel disease (IBD)	2/1245	56/7206	0.00377914265209
ko03022	Basal transcription factors	1/1245	44/7206	0.0042427603386
ko00071	Fatty acid degradation	1/1245	45/7206	0.0044474100729
ko00562	Inositol phosphate metabolism	26/1245	89/7206	0.00453285496093
ko00310	Lysine degradation	4/1245	73/7206	0.00463269985558
ko05131	Shigellosis	5/1245	82/7206	0.00477972641941
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1245	14/7206	0.00501903521062
ko00590	Arachidonic acid metabolism	2/1245	52/7206	0.00545049565971
ko05166	HTLV-I infection	33/1245	292/7206	0.00550702179087
ko04330	Notch signaling pathway	3/1245	62/7206	0.0062178263937
ko04622	RIG-I-like receptor signaling pathway	3/1245	62/7206	0.0062178263937
ko04658	Th1 and Th2 cell differentiation	7/1245	96/7206	0.00632167513514
ko04657	IL-17 signaling pathway	6/1245	87/7206	0.00656096647467
ko05133	Pertussis	6/1245	87/7206	0.00656096647467
ko04932	Non-alcoholic fatty liver disease (NAFLD)	18/1245	182/7206	0.00701334300466
ko05145	Toxoplasmosis	11/1245	126/7206	0.00855649934997
ko04630	Jak-STAT signaling pathway	12/1245	132/7206	0.0102131268743
ko03018	RNA degradation	6/1245	84/7206	0.0126230888944
ko04115	p53 signaling pathway	5/1245	74/7206	0.012820657134
ko04918	Thyroid hormone synthesis	24/1245	86/7206	0.0137961743251
ko00630	Glyoxylate and dicarboxylate metabolism	1/1245	38/7206	0.0152922987826
ko05410	Hypertrophic cardiomyopathy (HCM)	27/1245	100/7206	0.0155713406622
ko05144	Malaria	2/1245	45/7206	0.0169692123734
ko04270	Vascular smooth muscle contraction	38/1245	154/7206	0.0175411491962
ko04214	Apoptosis - fly	5/1245	72/7206	0.0177919112817
ko00290	Valine, leucine and isoleucine biosynthesis	3/1245	4/7206	0.0179257327149
ko00280	Valine, leucine and isoleucine degradation	3/1245	54/7206	0.0180664934989
ko05206	MicroRNAs in cancer	19/1245	177/7206	0.020094307538
ko04912	GnRH signaling pathway	31/1245	122/7206	0.0212730423361
ko00500	Starch and sucrose metabolism	1/1245	35/7206	0.022132272083
ko04620	Toll-like receptor signaling pathway	9/1245	100/7206	0.0236559717885
ko03320	PPAR signaling pathway	5/1245	69/7206	0.0243403210375
ko04922	Glucagon signaling pathway	32/1245	128/7206	0.0245735102461
ko05016	Huntington's disease	25/1245	215/7206	0.0274870369479
ko04015	Rap1 signaling pathway	62/1245	278/7206	0.0286152851592
ko01524	Platinum drug resistance	6/1245	76/7206	0.0313318878839
ko04217	Necroptosis	20/1245	178/7206	0.0343426826855
ko05222	Small cell lung cancer	8/1245	89/7206	0.0344308438267
ko00980	Metabolism of xenobiotics by cytochrome P450	2/1245	40/7206	0.035670511126
ko00380	Tryptophan metabolism	3/1245	50/7206	0.036768489912
ko05215	Prostate cancer	11/1245	111/7206	0.0419563901229
ko05418	Fluid shear stress and atherosclerosis	20/1245	173/7206	0.0420258443897
ko04916	Melanogenesis	34/1245	142/7206	0.0427450432649
ko04210	Apoptosis	21/1245	180/7206	0.0454641126028
ko04510	Focal adhesion	30/1245	240/7206	0.0458572279766
ko04930	Type II diabetes mellitus	15/1245	54/7206	0.0469195989796
ko05320	Autoimmune thyroid disease	1/1245	29/7206	0.0479452444319
ko05231	Choline metabolism in cancer	32/1245	134/7206	0.0491913085564
ko04142	Lysosome	17/1245	151/7206	0.0498424024101