ko pathway ratio_in_study ratio_in_pop p_value ko05033 Nicotine addiction 25/403 56/7206 2.65879187045e-17 ko04724 Glutamatergic synapse 38/403 152/7206 1.34700495876e-15 ko05032 Morphine addiction 30/403 110/7206 1.25280288171e-13 ko04727 GABAergic synapse 29/403 110/7206 8.4085595821e-13 ko04744 Phototransduction 17/403 36/7206 1.18601157067e-12 ko04723 Retrograde endocannabinoid signaling 36/403 175/7206 4.42306566288e-12 ko04728 Dopaminergic synapse 36/403 185/7206 2.43994394469e-11 ko04080 Neuroactive ligand-receptor interaction 51/403 423/7206 1.4258883915e-07 ko04721 Synaptic vesicle cycle 18/403 80/7206 2.81004654708e-07 ko04024 cAMP signaling pathway 38/403 279/7206 3.00494968766e-07 ko04713 Circadian entrainment 24/403 136/7206 3.95998514037e-07 ko04725 Cholinergic synapse 26/403 160/7206 6.90359616906e-07 ko04010 MAPK signaling pathway 39/403 321/7206 4.30507802811e-06 ko05030 Cocaine addiction 15/403 73/7206 9.22794807543e-06 ko04742 Taste transduction 13/403 61/7206 2.41908802722e-05 ko04726 Serotonergic synapse 20/403 137/7206 6.70534474873e-05 ko05203 Viral carcinogenesis 3/403 277/7206 0.000149838521201 ko05205 Proteoglycans in cancer 3/403 271/7206 0.000215847194323 ko04911 Insulin secretion 17/403 117/7206 0.000248125210355 ko04261 Adrenergic signaling in cardiomyocytes 25/403 205/7206 0.000262211324023 ko04514 Cell adhesion molecules (CAMs) 18/403 130/7206 0.00030366674455 ko04060 Cytokine-cytokine receptor interaction 1/403 191/7206 0.000332527154902 ko05031 Amphetamine addiction 14/403 91/7206 0.000478101015347 ko00604 Glycosphingolipid biosynthesis - ganglio series 5/403 14/7206 0.000701418309975 ko04720 Long-term potentiation 14/403 99/7206 0.00113085622493 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 12/403 79/7206 0.00134080249698 ko04072 Phospholipase D signaling pathway 22/403 197/7206 0.00227506265935 ko04144 Endocytosis 33/403 342/7206 0.00228699287196 ko04930 Type II diabetes mellitus 9/403 54/7206 0.00275609160391 ko04921 Oxytocin signaling pathway 22/403 209/7206 0.00347792436168 ko03040 Spliceosome 1/403 145/7206 0.00501528313038 ko04915 Estrogen signaling pathway 15/403 131/7206 0.00670986497796 ko04630 Jak-STAT signaling pathway 1/403 132/7206 0.00690124951865 ko04120 Ubiquitin mediated proteolysis 1/403 138/7206 0.00730735479893 ko03013 RNA transport 2/403 166/7206 0.00900925105227 ko05414 Dilated cardiomyopathy 13/403 112/7206 0.0109029280556 ko05231 Choline metabolism in cancer 15/403 134/7206 0.0114208790213 ko04260 Cardiac muscle contraction 12/403 98/7206 0.0115936269357 ko05410 Hypertrophic cardiomyopathy (HCM) 12/403 100/7206 0.012606693104 ko04022 cGMP-PKG signaling pathway 21/403 216/7206 0.0147217673656 ko04066 HIF-1 signaling pathway 1/403 123/7206 0.0151606659712 ko04110 Cell cycle 2/403 145/7206 0.0172846195943 ko04142 Lysosome 2/403 151/7206 0.0178989067797 ko04020 Calcium signaling pathway 24/403 265/7206 0.019405720432 ko00512 Mucin type O-glycan biosynthesis 5/403 29/7206 0.0208415958919 ko00240 Pyrimidine metabolism 1/403 110/7206 0.0210249300403 ko05014 Amyotrophic lateral sclerosis (ALS) 9/403 74/7206 0.0214935920881 ko04666 Fc gamma R-mediated phagocytosis 13/403 122/7206 0.0254062045035 ko05164 Influenza A 3/403 167/7206 0.0256325208585 ko04320 Dorso-ventral axis formation 5/403 31/7206 0.0272281643326 ko00513 Various types of N-glycan biosynthesis 6/403 42/7206 0.0280048925263 ko04070 Phosphatidylinositol signaling system 12/403 112/7206 0.0337847789378 ko04141 Protein processing in endoplasmic reticulum 4/403 184/7206 0.034628345799 ko04730 Long-term depression 9/403 78/7206 0.040160769808 ko04970 Salivary secretion 10/403 95/7206 0.0428745842966 ko05169 Epstein-Barr virus infection 5/403 206/7206 0.0442504192757 ko04217 Necroptosis 4/403 178/7206 0.0466840066187 ko04932 Non-alcoholic fatty liver disease (NAFLD) 4/403 182/7206 0.0475094307852 ko04670 Leukocyte transendothelial migration 3/403 151/7206 0.0482055109142 ko05322 Systemic lupus erythematosus 3/403 151/7206 0.0482055109142 ko00190 Oxidative phosphorylation 2/403 127/7206 0.0484395023146