ko pathway ratio_in_study ratio_in_pop p_value ko03040 Spliceosome 39/359 145/7206 6.15550452591e-19 ko03460 Fanconi anemia pathway 22/359 51/7206 4.85679624707e-16 ko03440 Homologous recombination 19/359 41/7206 9.9902325442e-15 ko04110 Cell cycle 33/359 145/7206 7.12724078968e-14 ko04111 Cell cycle - yeast 24/359 90/7206 5.50533035857e-12 ko03008 Ribosome biogenesis in eukaryotes 22/359 79/7206 1.68660657459e-11 ko03013 RNA transport 32/359 166/7206 2.07358393347e-11 ko04080 Neuroactive ligand-receptor interaction 1/359 423/7206 1.07343138947e-08 ko03410 Base excision repair 13/359 38/7206 1.63548027438e-08 ko00240 Pyrimidine metabolism 21/359 110/7206 7.87666798729e-08 ko03030 DNA replication 12/359 38/7206 1.6271340183e-07 ko04113 Meiosis - yeast 16/359 70/7206 2.17209031506e-07 ko04020 Calcium signaling pathway 1/359 265/7206 3.41856186055e-05 ko05322 Systemic lupus erythematosus 20/359 151/7206 5.39061555693e-05 ko03020 RNA polymerase 8/359 29/7206 5.98767561452e-05 ko04914 Progesterone-mediated oocyte maturation 15/359 104/7206 0.00017808655334 ko04144 Endocytosis 4/359 342/7206 0.000184208458127 ko05166 HTLV-I infection 29/359 292/7206 0.000305205108626 ko04024 cAMP signaling pathway 3/359 279/7206 0.000632165197356 ko05010 Alzheimer's disease 1/359 202/7206 0.00076255974037 ko03018 RNA degradation 12/359 84/7206 0.000853204041395 ko05203 Viral carcinogenesis 27/359 277/7206 0.000962775084798 ko03022 Basal transcription factors 8/359 44/7206 0.00128426037749 ko04151 PI3K-Akt signaling pathway 7/359 390/7206 0.00164448494413 ko03420 Nucleotide excision repair 8/359 46/7206 0.00173343441998 ko04114 Oocyte meiosis 16/359 139/7206 0.00219104568905 ko04261 Adrenergic signaling in cardiomyocytes 2/359 205/7206 0.00303502750376 ko04115 p53 signaling pathway 10/359 74/7206 0.00344977657109 ko04510 Focal adhesion 3/359 240/7206 0.00361573106554 ko04621 NOD-like receptor signaling pathway 1/359 157/7206 0.00482705046052 ko05034 Alcoholism 22/359 238/7206 0.00553424111205 ko04060 Cytokine-cytokine receptor interaction 2/359 191/7206 0.00621422729757 ko03015 mRNA surveillance pathway 11/359 93/7206 0.00624133577056 ko04142 Lysosome 1/359 151/7206 0.00707681672479 ko04724 Glutamatergic synapse 1/359 152/7206 0.00713717480118 ko05012 Parkinson's disease 1/359 155/7206 0.00744000059628 ko04728 Dopaminergic synapse 2/359 185/7206 0.00898510698154 ko04139 Mitophagy - yeast 6/359 37/7206 0.00918729433174 ko04550 Signaling pathways regulating pluripotency of stem cells 16/359 165/7206 0.00985186626776 ko04022 cGMP-PKG signaling pathway 3/359 216/7206 0.00995226908091 ko04723 Retrograde endocannabinoid signaling 2/359 175/7206 0.0125185681991 ko04921 Oxytocin signaling pathway 3/359 209/7206 0.014007808336 ko04713 Circadian entrainment 1/359 136/7206 0.0149985496501 ko04530 Tight junction 4/359 228/7206 0.0191255418763 ko04218 Cellular senescence 16/359 177/7206 0.0207661459166 ko00190 Oxidative phosphorylation 1/359 127/7206 0.0215056714163 ko01200 Carbon metabolism 1/359 128/7206 0.0216838039934 ko03430 Mismatch repair 4/359 22/7206 0.0217257584089 ko04014 Ras signaling pathway 6/359 279/7206 0.0237626143434 ko05152 Tuberculosis 3/359 187/7206 0.0258641063005 ko00230 Purine metabolism 17/359 194/7206 0.0272417963022 ko04911 Insulin secretion 1/359 117/7206 0.0307434016126 ko04668 TNF signaling pathway 1/359 120/7206 0.0312870854287 ko04750 Inflammatory mediator regulation of TRP channels 1/359 122/7206 0.0320208226605 ko04066 HIF-1 signaling pathway 1/359 123/7206 0.0324991417997 ko04010 MAPK signaling pathway 8/359 321/7206 0.0348263471344 ko04932 Non-alcoholic fatty liver disease (NAFLD) 3/359 182/7206 0.0360996048022 ko05202 Transcriptional misregulation in cancer 16/359 188/7206 0.038597282274 ko04810 Regulation of actin cytoskeleton 6/359 264/7206 0.0418816065015 ko04727 GABAergic synapse 1/359 110/7206 0.0444163849716 ko04972 Pancreatic secretion 1/359 111/7206 0.0446814004521