ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko05033	Nicotine addiction	40/521	56/7206	7.83787075894e-34
ko04724	Glutamatergic synapse	63/521	152/7206	4.12788923088e-33
ko04080	Neuroactive ligand-receptor interaction	99/521	423/7206	8.3936473443e-28
ko04723	Retrograde endocannabinoid signaling	57/521	175/7206	1.14159644781e-23
ko04727	GABAergic synapse	44/521	110/7206	1.41831528702e-22
ko05032	Morphine addiction	44/521	110/7206	1.41831528702e-22
ko04713	Circadian entrainment	44/521	136/7206	2.44866997683e-18
ko04728	Dopaminergic synapse	49/521	185/7206	2.81246129273e-16
ko04744	Phototransduction	21/521	36/7206	1.49716284527e-15
ko04721	Synaptic vesicle cycle	30/521	80/7206	7.74741880349e-15
ko04725	Cholinergic synapse	40/521	160/7206	1.35884258912e-12
ko04024	cAMP signaling pathway	55/521	279/7206	2.93488474342e-12
ko04726	Serotonergic synapse	36/521	137/7206	3.8617783799e-12
ko04020	Calcium signaling pathway	46/521	265/7206	1.61957077729e-08
ko04720	Long-term potentiation	25/521	99/7206	1.96219532281e-08
ko04921	Oxytocin signaling pathway	39/521	209/7206	2.55309649285e-08
ko04742	Taste transduction	19/521	61/7206	2.58116782994e-08
ko04911	Insulin secretion	27/521	117/7206	4.1996101123e-08
ko05030	Cocaine addiction	20/521	73/7206	1.22417913275e-07
ko05031	Amphetamine addiction	22/521	91/7206	3.22242163162e-07
ko04261	Adrenergic signaling in cardiomyocytes	36/521	205/7206	5.97691714364e-07
ko04970	Salivary secretion	22/521	95/7206	7.16431788987e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	19/521	74/7206	7.65124737622e-07
ko04730	Long-term depression	18/521	78/7206	7.76511502331e-06
ko04740	Olfactory transduction	18/521	80/7206	1.13237998061e-05
ko04010	MAPK signaling pathway	45/521	321/7206	1.27544553575e-05
ko04060	Cytokine-cytokine receptor interaction	1/521	191/7206	1.34035661576e-05
ko04972	Pancreatic secretion	21/521	111/7206	3.65145263182e-05
ko04022	cGMP-PKG signaling pathway	33/521	216/7206	4.05214650998e-05
ko04514	Cell adhesion molecules (CAMs)	23/521	130/7206	4.7867076588e-05
ko05164	Influenza A	1/521	167/7206	0.00010093086171
ko04925	Aldosterone synthesis and secretion	19/521	105/7206	0.000158401627418
ko05203	Viral carcinogenesis	6/521	277/7206	0.000317102930185
ko05205	Proteoglycans in cancer	6/521	271/7206	0.000437684159625
ko03040	Spliceosome	1/521	145/7206	0.000475654428069
ko04971	Gastric acid secretion	17/521	98/7206	0.000579646530969
ko04630	Jak-STAT signaling pathway	1/521	132/7206	0.0009873990982
ko04260	Cardiac muscle contraction	16/521	98/7206	0.00223520775676
ko04540	Gap junction	19/521	128/7206	0.00268067036455
ko04140	Autophagy - animal	3/521	164/7206	0.00335552687154
ko04068	FoxO signaling pathway	3/521	167/7206	0.00348312472222
ko04150	mTOR signaling pathway	4/521	184/7206	0.00366338224968
ko04141	Protein processing in endoplasmic reticulum	4/521	184/7206	0.00366338224968
ko05169	Epstein-Barr virus infection	5/521	206/7206	0.00383363870275
ko04120	Ubiquitin mediated proteolysis	2/521	138/7206	0.00411366866238
ko05215	Prostate cancer	1/521	111/7206	0.00461570560152
ko04924	Renin secretion	14/521	86/7206	0.0047180720897
ko05034	Alcoholism	29/521	238/7206	0.00481640549661
ko05168	Herpes simplex infection	4/521	182/7206	0.00522235260096
ko04932	Non-alcoholic fatty liver disease (NAFLD)	4/521	182/7206	0.00522235260096
ko05322	Systemic lupus erythematosus	3/521	151/7206	0.00659154867219
ko04014	Ras signaling pathway	32/521	279/7206	0.00894464762564
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	12/521	79/7206	0.0132468033279
ko04550	Signaling pathways regulating pluripotency of stem cells	4/521	165/7206	0.0136936388487
ko00604	Glycosphingolipid biosynthesis - ganglio series	4/521	14/7206	0.0150832388324
ko04964	Proximal tubule bicarbonate reclamation	6/521	29/7206	0.0157670395239
ko05414	Dilated cardiomyopathy	15/521	112/7206	0.0165128669471
ko04218	Cellular senescence	5/521	177/7206	0.0179018933292
ko05166	HTLV-I infection	11/521	292/7206	0.0201784945351
ko04146	Peroxisome	1/521	89/7206	0.0207736025122
ko04072	Phospholipase D signaling pathway	23/521	197/7206	0.0241378753839
ko05161	Hepatitis B	5/521	173/7206	0.0243947644455
ko05224	Breast cancer	5/521	174/7206	0.0246479669584
ko04062	Chemokine signaling pathway	23/521	201/7206	0.0261284290851
ko04810	Regulation of actin cytoskeleton	10/521	264/7206	0.0282960065591
ko05230	Central carbon metabolism in cancer	1/521	81/7206	0.0292721408558
ko00830	Retinol metabolism	7/521	42/7206	0.029298885602
ko04137	Mitophagy - animal	1/521	82/7206	0.0294997139627
ko05218	Melanoma	1/521	85/7206	0.0311099653759
ko05220	Chronic myeloid leukemia	1/521	85/7206	0.0311099653759
ko04071	Sphingolipid signaling pathway	19/521	162/7206	0.0312961657804
ko03013	RNA transport	5/521	166/7206	0.0324250983593
ko04110	Cell cycle	4/521	145/7206	0.0337770497124
ko04966	Collecting duct acid secretion	5/521	26/7206	0.0359125253108
ko04961	Endocrine and other factor-regulated calcium reabsorption	9/521	59/7206	0.0363916755377
ko04915	Estrogen signaling pathway	16/521	131/7206	0.0384517712929
ko04371	Apelin signaling pathway	20/521	177/7206	0.0395782562556
ko05140	Leishmaniasis	1/521	75/7206	0.0422623523174
ko04621	NOD-like receptor signaling pathway	5/521	157/7206	0.0429981096208
ko03008	Ribosome biogenesis in eukaryotes	1/521	79/7206	0.0444864832654
ko04976	Bile secretion	11/521	80/7206	0.0455672231544
ko04750	Inflammatory mediator regulation of TRP channels	15/521	122/7206	0.0491297291648