ko pathway ratio_in_study ratio_in_pop p_value ko04721 Synaptic vesicle cycle 30/425 80/7206 2.81236261114e-17 ko04724 Glutamatergic synapse 41/425 152/7206 3.34016986728e-17 ko05033 Nicotine addiction 24/425 56/7206 1.25557691876e-15 ko04728 Dopaminergic synapse 38/425 185/7206 5.93421306741e-12 ko04744 Phototransduction 16/425 36/7206 3.98474886786e-11 ko04727 GABAergic synapse 27/425 110/7206 1.11298978816e-10 ko04080 Neuroactive ligand-receptor interaction 59/425 423/7206 3.15210907941e-10 ko05032 Morphine addiction 25/425 110/7206 3.14647263448e-09 ko04723 Retrograde endocannabinoid signaling 31/425 175/7206 2.44493548706e-08 ko04911 Insulin secretion 24/425 117/7206 5.50405360977e-08 ko04713 Circadian entrainment 25/425 136/7206 2.75730439147e-07 ko04024 cAMP signaling pathway 39/425 279/7206 3.4194129696e-07 ko05030 Cocaine addiction 17/425 73/7206 7.57198052871e-07 ko05203 Viral carcinogenesis 1/425 277/7206 1.38184044161e-06 ko04725 Cholinergic synapse 26/425 160/7206 1.8963404154e-06 ko04726 Serotonergic synapse 23/425 137/7206 4.25299587337e-06 ko04514 Cell adhesion molecules (CAMs) 22/425 130/7206 6.01987682638e-06 ko04970 Salivary secretion 18/425 95/7206 8.49200127369e-06 ko05205 Proteoglycans in cancer 3/425 271/7206 0.000104350622968 ko05014 Amyotrophic lateral sclerosis (ALS) 13/425 74/7206 0.000334399846635 ko04261 Adrenergic signaling in cardiomyocytes 25/425 205/7206 0.000445762056687 ko04020 Calcium signaling pathway 30/425 265/7206 0.000475151947876 ko05164 Influenza A 1/425 167/7206 0.000705612882531 ko04972 Pancreatic secretion 16/425 111/7206 0.000737405458625 ko05166 HTLV-I infection 5/425 292/7206 0.000820111331111 ko04964 Proximal tubule bicarbonate reclamation 7/425 29/7206 0.00118557023827 ko04060 Cytokine-cytokine receptor interaction 2/425 191/7206 0.00149250047697 ko04730 Long-term depression 12/425 78/7206 0.00188466269732 ko05168 Herpes simplex infection 2/425 182/7206 0.00208744641719 ko04932 Non-alcoholic fatty liver disease (NAFLD) 2/425 182/7206 0.00208744641719 ko05322 Systemic lupus erythematosus 1/425 151/7206 0.00233830376192 ko04976 Bile secretion 12/425 80/7206 0.00234993860327 ko05031 Amphetamine addiction 13/425 91/7206 0.00245858748629 ko04810 Regulation of actin cytoskeleton 5/425 264/7206 0.0029968869999 ko03040 Spliceosome 1/425 145/7206 0.00346903516571 ko04974 Protein digestion and absorption 13/425 96/7206 0.00396149741868 ko04120 Ubiquitin mediated proteolysis 1/425 138/7206 0.00502195986524 ko04140 Autophagy - animal 2/425 164/7206 0.00626445626948 ko04740 Olfactory transduction 11/425 80/7206 0.00692073820898 ko04010 MAPK signaling pathway 31/425 321/7206 0.00708572656881 ko04720 Long-term potentiation 13/425 99/7206 0.00750559749927 ko04978 Mineral absorption 7/425 40/7206 0.008088294068 ko04742 Taste transduction 9/425 61/7206 0.00892116070317 ko04668 TNF signaling pathway 1/425 120/7206 0.00997154146537 ko05169 Epstein-Barr virus infection 4/425 206/7206 0.0100300372977 ko04211 Longevity regulating pathway 1/425 123/7206 0.0103036848248 ko04022 cGMP-PKG signaling pathway 22/425 216/7206 0.0116625586718 ko04110 Cell cycle 2/425 145/7206 0.0121377080121 ko05161 Hepatitis B 3/425 173/7206 0.0133350378075 ko04966 Collecting duct acid secretion 5/425 26/7206 0.0163766879908 ko04924 Renin secretion 11/425 86/7206 0.0169807889951 ko04510 Focal adhesion 6/425 240/7206 0.0176036979054 ko04068 FoxO signaling pathway 3/425 167/7206 0.0185981442382 ko00965 Betalain biosynthesis 2/425 4/7206 0.0192301141824 ko05215 Prostate cancer 1/425 111/7206 0.0222405318459 ko04630 Jak-STAT signaling pathway 2/425 132/7206 0.0241942862826 ko04621 NOD-like receptor signaling pathway 3/425 157/7206 0.0254299554006 ko05200 Pathways in cancer 18/425 492/7206 0.0286555007692 ko05110 Vibrio cholerae infection 8/425 63/7206 0.0307233147155 ko04660 T cell receptor signaling pathway 2/425 124/7206 0.0339523338221 ko04940 Type I diabetes mellitus 5/425 32/7206 0.0375911988736 ko05211 Renal cell carcinoma 1/425 96/7206 0.0451026751607 ko00604 Glycosphingolipid biosynthesis - ganglio series 3/425 14/7206 0.0456014743246 ko05418 Fluid shear stress and atherosclerosis 4/425 173/7206 0.0474647199087 ko05224 Breast cancer 4/425 174/7206 0.0479128500097