ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	199/1144	423/7206	3.47364899319e-55
ko05033	Nicotine addiction	50/1144	56/7206	5.33270177924e-34
ko04724	Glutamatergic synapse	89/1144	152/7206	6.67434315095e-34
ko04713	Circadian entrainment	79/1144	136/7206	7.68135024047e-30
ko04727	GABAergic synapse	69/1144	110/7206	4.55549850504e-29
ko05032	Morphine addiction	69/1144	110/7206	4.55549850504e-29
ko04728	Dopaminergic synapse	87/1144	185/7206	5.65889444296e-24
ko04725	Cholinergic synapse	78/1144	160/7206	7.9070777536e-23
ko04721	Synaptic vesicle cycle	50/1144	80/7206	2.94397153522e-21
ko04723	Retrograde endocannabinoid signaling	80/1144	175/7206	3.84144837142e-21
ko04024	cAMP signaling pathway	102/1144	279/7206	7.18833007689e-18
ko04742	Taste transduction	39/1144	61/7206	2.3832268827e-17
ko04020	Calcium signaling pathway	97/1144	265/7206	4.79496298145e-17
ko04726	Serotonergic synapse	63/1144	137/7206	4.89600562599e-17
ko04744	Phototransduction	28/1144	36/7206	2.59759469667e-16
ko04911	Insulin secretion	56/1144	117/7206	3.02534237763e-16
ko04740	Olfactory transduction	42/1144	80/7206	2.83060163673e-14
ko04720	Long-term potentiation	46/1144	99/7206	5.60448905044e-13
ko04921	Oxytocin signaling pathway	75/1144	209/7206	6.87164346495e-13
ko04261	Adrenergic signaling in cardiomyocytes	74/1144	205/7206	7.94252679427e-13
ko05031	Amphetamine addiction	43/1144	91/7206	1.58093732158e-12
ko04970	Salivary secretion	43/1144	95/7206	9.68694764174e-12
ko03040	Spliceosome	1/1144	145/7206	5.14464601152e-10
ko05203	Viral carcinogenesis	14/1144	277/7206	2.04927000292e-08
ko04925	Aldosterone synthesis and secretion	40/1144	105/7206	3.55245551143e-08
ko05030	Cocaine addiction	31/1144	73/7206	4.94763867834e-08
ko04360	Axon guidance	69/1144	233/7206	7.78519608439e-08
ko04971	Gastric acid secretion	37/1144	98/7206	1.45234936344e-07
ko04745	Phototransduction - fly	19/1144	38/7206	9.62308787255e-07
ko05322	Systemic lupus erythematosus	5/1144	151/7206	1.35029583029e-06
ko04010	MAPK signaling pathway	84/1144	321/7206	1.47258082865e-06
ko05168	Herpes simplex infection	8/1144	182/7206	1.58447790755e-06
ko04060	Cytokine-cytokine receptor interaction	9/1144	191/7206	1.77747198822e-06
ko04621	NOD-like receptor signaling pathway	6/1144	157/7206	2.39327902753e-06
ko04022	cGMP-PKG signaling pathway	61/1144	216/7206	2.74217180263e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1144	74/7206	3.57729807002e-06
ko04540	Gap junction	41/1144	128/7206	4.08205300636e-06
ko03013	RNA transport	7/1144	166/7206	4.25588145637e-06
ko04730	Long-term depression	29/1144	78/7206	4.91878854018e-06
ko05164	Influenza A	8/1144	167/7206	1.33619033709e-05
ko04141	Protein processing in endoplasmic reticulum	10/1144	184/7206	2.13942356613e-05
ko04750	Inflammatory mediator regulation of TRP channels	38/1144	122/7206	2.47100093095e-05
ko04120	Ubiquitin mediated proteolysis	6/1144	138/7206	3.05546671899e-05
ko04972	Pancreatic secretion	35/1144	111/7206	3.35789967462e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1144	79/7206	6.29444601155e-05
ko04961	Endocrine and other factor-regulated calcium reabsorption	22/1144	59/7206	8.65715139864e-05
ko04260	Cardiac muscle contraction	31/1144	98/7206	0.000119238177056
ko04514	Cell adhesion molecules (CAMs)	38/1144	130/7206	0.000133761467722
ko04924	Renin secretion	28/1144	86/7206	0.00013659805724
ko04110	Cell cycle	8/1144	145/7206	0.000199584789489
ko05414	Dilated cardiomyopathy	33/1144	112/7206	0.000227568518919
ko04070	Phosphatidylinositol signaling system	33/1144	112/7206	0.000227568518919
ko04966	Collecting duct acid secretion	12/1144	26/7206	0.000265949648926
ko03008	Ribosome biogenesis in eukaryotes	2/1144	79/7206	0.000267248145249
ko04014	Ras signaling pathway	67/1144	279/7206	0.000305411393321
ko05162	Measles	6/1144	120/7206	0.000355796961039
ko04612	Antigen processing and presentation	2/1144	77/7206	0.000406748348063
ko04072	Phospholipase D signaling pathway	50/1144	197/7206	0.000489227741656
ko05110	Vibrio cholerae infection	21/1144	63/7206	0.000690138311358
ko00480	Glutathione metabolism	1/1144	55/7206	0.00133078006395
ko04932	Non-alcoholic fatty liver disease (NAFLD)	14/1144	182/7206	0.00134835323318
ko04915	Estrogen signaling pathway	35/1144	131/7206	0.00150195523268
ko05205	Proteoglycans in cancer	25/1144	271/7206	0.00163650187367
ko04976	Bile secretion	24/1144	80/7206	0.00169158509545
ko04146	Peroxisome	4/1144	89/7206	0.00182094437433
ko05169	Epstein-Barr virus infection	17/1144	206/7206	0.00182517151284
ko05166	HTLV-I infection	28/1144	292/7206	0.00184765033613
ko04064	NF-kappa B signaling pathway	5/1144	96/7206	0.00186187239565
ko00590	Arachidonic acid metabolism	1/1144	52/7206	0.00200627398317
ko05140	Leishmaniasis	3/1144	75/7206	0.00222632479057
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1144	14/7206	0.00305861019726
ko04214	Apoptosis - fly	3/1144	72/7206	0.00320225290941
ko00240	Pyrimidine metabolism	7/1144	110/7206	0.00361827676553
ko04626	Plant-pathogen interaction	8/1144	18/7206	0.0038731807719
ko04610	Complement and coagulation cascades	4/1144	79/7206	0.0049514505805
ko04912	GnRH signaling pathway	31/1144	122/7206	0.00572342574912
ko04371	Apelin signaling pathway	42/1144	177/7206	0.00642744365521
ko05144	Malaria	1/1144	45/7206	0.00679647724815
ko00071	Fatty acid degradation	1/1144	45/7206	0.00679647724815
ko03022	Basal transcription factors	1/1144	44/7206	0.00680154233647
ko04658	Th1 and Th2 cell differentiation	6/1144	96/7206	0.00701568225107
ko03420	Nucleotide excision repair	1/1144	46/7206	0.00702533821315
ko05418	Fluid shear stress and atherosclerosis	15/1144	173/7206	0.00807123913279
ko05161	Hepatitis B	15/1144	173/7206	0.00807123913279
ko04217	Necroptosis	16/1144	178/7206	0.00916266573459
ko00310	Lysine degradation	4/1144	73/7206	0.00982058517535
ko03018	RNA degradation	5/1144	84/7206	0.00989683482348
ko04923	Regulation of lipolysis in adipocytes	21/1144	77/7206	0.0109933387224
ko00330	Arginine and proline metabolism	3/1144	61/7206	0.0134048478422
ko04622	RIG-I-like receptor signaling pathway	3/1144	62/7206	0.0134754116142
ko05131	Shigellosis	5/1144	82/7206	0.0138875207896
ko04630	Jak-STAT signaling pathway	11/1144	132/7206	0.0156045484328
ko00140	Steroid hormone biosynthesis	1/1144	41/7206	0.0158391354974
ko05231	Choline metabolism in cancer	32/1144	134/7206	0.0162533852459
ko04964	Proximal tubule bicarbonate reclamation	10/1144	29/7206	0.0174669138013
ko04657	IL-17 signaling pathway	6/1144	87/7206	0.0177224851117
ko05133	Pertussis	6/1144	87/7206	0.0177224851117
ko03320	PPAR signaling pathway	4/1144	69/7206	0.0192709959092
ko04350	TGF-beta signaling pathway	8/1144	103/7206	0.0205402886342
ko05016	Huntington's disease	22/1144	215/7206	0.0224798089163
ko00630	Glyoxylate and dicarboxylate metabolism	1/1144	38/7206	0.0231707790372
ko03410	Base excision repair	1/1144	38/7206	0.0231707790372
ko04015	Rap1 signaling pathway	58/1144	278/7206	0.0236723945755
ko04062	Chemokine signaling pathway	44/1144	201/7206	0.0238148882063
ko01524	Platinum drug resistance	5/1144	76/7206	0.0257768478261
ko05145	Toxoplasmosis	11/1144	126/7206	0.0262090712139
ko05321	Inflammatory bowel disease (IBD)	3/1144	56/7206	0.0268410447288
ko00562	Inositol phosphate metabolism	22/1144	89/7206	0.0278512342697
ko04722	Neurotrophin signaling pathway	36/1144	160/7206	0.0279022254859
ko05214	Glioma	20/1144	79/7206	0.0289299323162
ko04960	Aldosterone-regulated sodium reabsorption	12/1144	41/7206	0.029152985334
ko04210	Apoptosis	18/1144	180/7206	0.0295509186854
ko05034	Alcoholism	50/1144	238/7206	0.030455837914
ko04973	Carbohydrate digestion and absorption	12/1144	42/7206	0.0326215412896
ko00860	Porphyrin and chlorophyll metabolism	1/1144	34/7206	0.0335437942453
ko04975	Fat digestion and absorption	1/1144	35/7206	0.0340098742629
ko04115	p53 signaling pathway	5/1144	74/7206	0.0357101728251
ko04330	Notch signaling pathway	4/1144	62/7206	0.0367350534636
ko04218	Cellular senescence	18/1144	177/7206	0.0367407030715
ko04918	Thyroid hormone synthesis	21/1144	86/7206	0.0367594604643
ko05410	Hypertrophic cardiomyopathy (HCM)	24/1144	100/7206	0.0372521614694
ko04640	Hematopoietic cell lineage	4/1144	64/7206	0.0372600718696
ko00280	Valine, leucine and isoleucine degradation	3/1144	54/7206	0.0380113412607
ko04711	Circadian rhythm - fly	5/1144	13/7206	0.0423862196955
ko04670	Leukocyte transendothelial migration	15/1144	151/7206	0.0426813761011
ko05215	Prostate cancer	10/1144	111/7206	0.0487911338515
ko04071	Sphingolipid signaling pathway	35/1144	162/7206	0.0498808077951