ko pathway ratio_in_study ratio_in_pop p_value ko05164 Influenza A 24/185 167/7206 4.02662484095e-12 ko04380 Osteoclast differentiation 20/185 134/7206 1.40217837599e-10 ko04668 TNF signaling pathway 18/185 120/7206 1.13693919925e-09 ko05161 Hepatitis B 21/185 173/7206 2.38466634548e-09 ko04621 NOD-like receptor signaling pathway 20/185 157/7206 2.50611918785e-09 ko04620 Toll-like receptor signaling pathway 16/185 100/7206 3.80419848511e-09 ko05162 Measles 17/185 120/7206 8.26960993393e-09 ko05168 Herpes simplex infection 20/185 182/7206 3.29631626224e-08 ko04630 Jak-STAT signaling pathway 17/185 132/7206 3.57507966566e-08 ko05160 Hepatitis C 18/185 153/7206 5.81562937942e-08 ko05167 Kaposi's sarcoma-associated herpesvirus infection 19/185 191/7206 3.6331728843e-07 ko05145 Toxoplasmosis 15/185 126/7206 6.68887037124e-07 ko04064 NF-kappa B signaling pathway 13/185 96/7206 8.65033610847e-07 ko05142 Chagas disease (American trypanosomiasis) 15/185 130/7206 1.00450077229e-06 ko04622 RIG-I-like receptor signaling pathway 10/185 62/7206 3.29271973128e-06 ko04060 Cytokine-cytokine receptor interaction 17/185 191/7206 7.14720588641e-06 ko04933 AGE-RAGE signaling pathway in diabetic complications 14/185 135/7206 8.31745047337e-06 ko04917 Prolactin signaling pathway 11/185 87/7206 1.21484989978e-05 ko05133 Pertussis 11/185 87/7206 1.21484989978e-05 ko04210 Apoptosis 16/185 180/7206 1.36747080885e-05 ko05140 Leishmaniasis 10/185 75/7206 1.90099694408e-05 ko04658 Th1 and Th2 cell differentiation 11/185 96/7206 3.12940032935e-05 ko04931 Insulin resistance 13/185 137/7206 4.5657535174e-05 ko04657 IL-17 signaling pathway 10/185 87/7206 7.02788456296e-05 ko04623 Cytosolic DNA-sensing pathway 7/185 41/7206 7.04541846087e-05 ko05321 Inflammatory bowel disease (IBD) 8/185 56/7206 8.02599647933e-05 ko04920 Adipocytokine signaling pathway 10/185 89/7206 8.54467382617e-05 ko04217 Necroptosis 14/185 178/7206 0.000180747452902 ko05152 Tuberculosis 14/185 187/7206 0.000302368453887 ko04672 Intestinal immune network for IgA production 6/185 37/7206 0.000316332774195 ko04659 Th17 cell differentiation 10/185 106/7206 0.000367185781562 ko05166 HTLV-I infection 18/185 292/7206 0.000477967014601 ko04115 p53 signaling pathway 8/185 74/7206 0.000574543067576 ko04932 Non-alcoholic fatty liver disease (NAFLD) 13/185 182/7206 0.000776412889972 ko05132 Salmonella infection 9/185 98/7206 0.000877605243521 ko05340 Primary immunodeficiency 5/185 30/7206 0.000893351684008 ko05212 Pancreatic cancer 8/185 83/7206 0.00123586815692 ko04660 T cell receptor signaling pathway 10/185 124/7206 0.00126336594697 ko01522 Endocrine resistance 10/185 124/7206 0.00126336594697 ko04662 B cell receptor signaling pathway 8/185 88/7206 0.00180644882033 ko04218 Cellular senescence 12/185 177/7206 0.00192883573714 ko04080 Neuroactive ligand-receptor interaction 2/185 423/7206 0.00214082509225 ko05134 Legionellosis 7/185 74/7206 0.00276727739261 ko04068 FoxO signaling pathway 11/185 167/7206 0.00369282135753 ko00140 Steroid hormone biosynthesis 5/185 41/7206 0.00374081506988 ko00643 Styrene degradation 2/185 4/7206 0.00380182684624 ko04211 Longevity regulating pathway 9/185 123/7206 0.00424398510446 ko04976 Bile secretion 7/185 80/7206 0.00429547621775 ko04062 Chemokine signaling pathway 12/185 201/7206 0.00545147159541 ko05144 Malaria 5/185 45/7206 0.00561599164537 ko01521 EGFR tyrosine kinase inhibitor resistance 8/185 106/7206 0.00573708548085 ko05210 Colorectal cancer 7/185 86/7206 0.00639058436236 ko05169 Epstein-Barr virus infection 12/185 206/7206 0.0066069618905 ko05215 Prostate cancer 8/185 111/7206 0.00753925842507 ko04624 Toll and Imd signaling pathway 5/185 49/7206 0.00807314665238 ko05120 Epithelial cell signaling in Helicobacter pylori infection 7/185 92/7206 0.00916730253709 ko00362 Benzoate degradation 2/185 6/7206 0.00918699993221 ko05150 Staphylococcus aureus infection 4/185 36/7206 0.0130450690017 ko04066 HIF-1 signaling pathway 8/185 123/7206 0.0135785726472 ko00120 Primary bile acid biosynthesis 3/185 20/7206 0.0137584039568 ko04610 Complement and coagulation cascades 6/185 79/7206 0.0155914864892 ko05131 Shigellosis 6/185 82/7206 0.0184493602721 ko04137 Mitophagy - animal 6/185 82/7206 0.0184493602721 ko04915 Estrogen signaling pathway 8/185 131/7206 0.019206700587 ko04960 Aldosterone-regulated sodium reabsorption 4/185 41/7206 0.0203189338695 ko05220 Chronic myeloid leukemia 6/185 85/7206 0.0216471423555 ko04012 ErbB signaling pathway 7/185 109/7206 0.021731354743 ko05221 Acute myeloid leukemia 5/185 63/7206 0.0223519821044 ko00401 Novobiocin biosynthesis 1/185 1/7206 0.0256730502359 ko05323 Rheumatoid arthritis 6/185 89/7206 0.0264667525604 ko03320 PPAR signaling pathway 5/185 69/7206 0.0316405271521 ko04010 MAPK signaling pathway 14/185 321/7206 0.0457302401707 ko05143 African trypanosomiasis 3/185 32/7206 0.0478913244473 ko04930 Type II diabetes mellitus 4/185 54/7206 0.0491959444328