ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	160/821	423/7206	4.6410365049e-49
ko05033	Nicotine addiction	44/821	56/7206	1.5938545205e-31
ko04724	Glutamatergic synapse	71/821	152/7206	2.37246429197e-28
ko04728	Dopaminergic synapse	70/821	185/7206	2.28406508817e-21
ko05032	Morphine addiction	52/821	110/7206	2.61406734666e-21
ko04713	Circadian entrainment	56/821	136/7206	2.59562696334e-19
ko04727	GABAergic synapse	49/821	110/7206	9.03000584716e-19
ko04024	cAMP signaling pathway	80/821	279/7206	6.92054148436e-16
ko04723	Retrograde endocannabinoid signaling	59/821	175/7206	1.91983577506e-15
ko04725	Cholinergic synapse	55/821	160/7206	6.95952711763e-15
ko04721	Synaptic vesicle cycle	36/821	80/7206	2.78292980189e-14
ko04020	Calcium signaling pathway	68/821	265/7206	3.90551729993e-11
ko04921	Oxytocin signaling pathway	58/821	209/7206	4.33875506871e-11
ko04726	Serotonergic synapse	44/821	137/7206	5.11258520087e-11
ko04261	Adrenergic signaling in cardiomyocytes	56/821	205/7206	1.682618106e-10
ko04911	Insulin secretion	39/821	117/7206	1.87640021579e-10
ko05031	Amphetamine addiction	33/821	91/7206	3.96188649207e-10
ko04742	Taste transduction	25/821	61/7206	2.87289693743e-09
ko05030	Cocaine addiction	27/821	73/7206	9.65762805078e-09
ko04010	MAPK signaling pathway	68/821	321/7206	2.13120825756e-07
ko04360	Axon guidance	54/821	233/7206	2.64659193618e-07
ko03040	Spliceosome	1/821	145/7206	8.75293416826e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	24/821	74/7206	1.07702963318e-06
ko04720	Long-term potentiation	28/821	99/7206	3.09080836182e-06
ko04970	Salivary secretion	27/821	95/7206	4.18112987263e-06
ko05203	Viral carcinogenesis	11/821	277/7206	1.18883088267e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	23/821	79/7206	1.38625719855e-05
ko05322	Systemic lupus erythematosus	3/821	151/7206	2.43732645326e-05
ko04022	cGMP-PKG signaling pathway	46/821	216/7206	2.67470111271e-05
ko05168	Herpes simplex infection	5/821	182/7206	2.72394374247e-05
ko04514	Cell adhesion molecules (CAMs)	31/821	130/7206	6.19548500245e-05
ko04060	Cytokine-cytokine receptor interaction	6/821	191/7206	6.61210978142e-05
ko04120	Ubiquitin mediated proteolysis	3/821	138/7206	0.000110687371251
ko05164	Influenza A	5/821	167/7206	0.000111484646051
ko04925	Aldosterone synthesis and secretion	26/821	105/7206	0.00012763480787
ko03013	RNA transport	5/821	166/7206	0.000163001953549
ko04260	Cardiac muscle contraction	24/821	98/7206	0.000283299552157
ko04621	NOD-like receptor signaling pathway	5/821	157/7206	0.000315011495557
ko04972	Pancreatic secretion	26/821	111/7206	0.000388755277361
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/821	14/7206	0.000404745547871
ko05414	Dilated cardiomyopathy	26/821	112/7206	0.000410807339943
ko04730	Long-term depression	20/821	78/7206	0.000414667130115
ko05205	Proteoglycans in cancer	14/821	271/7206	0.000423962059005
ko04971	Gastric acid secretion	23/821	98/7206	0.000594744788159
ko04014	Ras signaling pathway	50/821	279/7206	0.0010010205209
ko03008	Ribosome biogenesis in eukaryotes	1/821	79/7206	0.00116193328905
ko04141	Protein processing in endoplasmic reticulum	8/821	184/7206	0.00132858665213
ko04924	Renin secretion	20/821	86/7206	0.00164192167346
ko04612	Antigen processing and presentation	1/821	77/7206	0.00173465043518
ko00240	Pyrimidine metabolism	3/821	110/7206	0.00206611178657
ko05410	Hypertrophic cardiomyopathy (HCM)	22/821	100/7206	0.00215267285271
ko04214	Apoptosis - fly	1/821	72/7206	0.0025487745334
ko04146	Peroxisome	2/821	89/7206	0.0035732942494
ko04070	Phosphatidylinositol signaling system	23/821	112/7206	0.00410784267135
ko04072	Phospholipase D signaling pathway	36/821	197/7206	0.00413357892732
ko04915	Estrogen signaling pathway	26/821	131/7206	0.00490028762707
ko04015	Rap1 signaling pathway	47/821	278/7206	0.00502861049957
ko04217	Necroptosis	9/821	178/7206	0.00556958184246
ko04064	NF-kappa B signaling pathway	3/821	96/7206	0.00564382262974
ko04961	Endocrine and other factor-regulated calcium reabsorption	14/821	59/7206	0.00623840332841
ko04966	Collecting duct acid secretion	8/821	26/7206	0.00656421764596
ko04930	Type II diabetes mellitus	13/821	54/7206	0.00783957869326
ko04371	Apelin signaling pathway	32/821	177/7206	0.00789185836763
ko04745	Phototransduction - fly	10/821	38/7206	0.00839019975505
ko05162	Measles	5/821	120/7206	0.00853342623355
ko04640	Hematopoietic cell lineage	1/821	64/7206	0.00854588793556
ko05169	Epstein-Barr virus infection	12/821	206/7206	0.00996355233416
ko05140	Leishmaniasis	2/821	75/7206	0.0101676232992
ko04140	Autophagy - animal	9/821	164/7206	0.0126050043985
ko04964	Proximal tubule bicarbonate reclamation	8/821	29/7206	0.0132574927904
ko05161	Hepatitis B	10/821	173/7206	0.0151733517752
ko04540	Gap junction	24/821	128/7206	0.0158668408794
ko05215	Prostate cancer	5/821	111/7206	0.0158757884262
ko04744	Phototransduction	9/821	36/7206	0.0170524627205
ko00480	Glutathione metabolism	1/821	55/7206	0.0177718420076
ko04932	Non-alcoholic fatty liver disease (NAFLD)	11/821	182/7206	0.0179221623662
ko04740	Olfactory transduction	16/821	80/7206	0.0207484305742
ko00533	Glycosaminoglycan biosynthesis - keratan sulfate	5/821	15/7206	0.02145321548
ko00590	Arachidonic acid metabolism	1/821	52/7206	0.0262489735508
ko04391	Hippo signaling pathway - fly	17/821	90/7206	0.029922061987
ko04510	Focal adhesion	17/821	240/7206	0.0299554581255
ko01200	Carbon metabolism	7/821	128/7206	0.0340175037508
ko04670	Leukocyte transendothelial migration	9/821	151/7206	0.0370537375253
ko05016	Huntington's disease	15/821	215/7206	0.037998609074
ko00270	Cysteine and methionine metabolism	1/821	47/7206	0.0381194021001
ko04210	Apoptosis	12/821	180/7206	0.0429688684675
ko00561	Glycerolipid metabolism	2/821	63/7206	0.0431771687466
ko01524	Platinum drug resistance	3/821	76/7206	0.043374622655
ko04071	Sphingolipid signaling pathway	27/821	162/7206	0.0440410498148
ko04626	Plant-pathogen interaction	5/821	18/7206	0.0459557649551
ko04110	Cell cycle	9/821	145/7206	0.0470903765797
ko05034	Alcoholism	37/821	238/7206	0.0480138735531