ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	202/1189	423/7206	1.95202981881e-54
ko04724	Glutamatergic synapse	91/1189	152/7206	2.40224500791e-34
ko05033	Nicotine addiction	47/1189	56/7206	1.26638302336e-28
ko05032	Morphine addiction	68/1189	110/7206	4.61012937753e-27
ko04713	Circadian entrainment	76/1189	136/7206	4.27315702104e-26
ko04727	GABAergic synapse	66/1189	110/7206	3.17780416159e-25
ko04721	Synaptic vesicle cycle	51/1189	80/7206	1.88791559249e-21
ko04728	Dopaminergic synapse	84/1189	185/7206	8.94867952702e-21
ko04725	Cholinergic synapse	76/1189	160/7206	2.41439171334e-20
ko04024	cAMP signaling pathway	106/1189	279/7206	1.07594402286e-18
ko04723	Retrograde endocannabinoid signaling	76/1189	175/7206	1.6214402295e-17
ko04020	Calcium signaling pathway	100/1189	265/7206	1.87923187598e-17
ko04911	Insulin secretion	56/1189	117/7206	1.77275693282e-15
ko04726	Serotonergic synapse	60/1189	137/7206	2.82031410835e-14
ko04742	Taste transduction	36/1189	61/7206	5.3995182623e-14
ko04921	Oxytocin signaling pathway	79/1189	209/7206	6.79573926986e-14
ko04744	Phototransduction	25/1189	36/7206	2.06497332671e-12
ko05031	Amphetamine addiction	43/1189	91/7206	6.05275406909e-12
ko04261	Adrenergic signaling in cardiomyocytes	72/1189	205/7206	4.48613302704e-11
ko04720	Long-term potentiation	43/1189	99/7206	1.86986877545e-10
ko03040	Spliceosome	1/1189	145/7206	1.94539984354e-10
ko04970	Salivary secretion	41/1189	95/7206	6.30498394293e-10
ko03010	Ribosome	1/1189	129/7206	2.53684533332e-09
ko04022	cGMP-PKG signaling pathway	67/1189	216/7206	7.19550872974e-08
ko04925	Aldosterone synthesis and secretion	40/1189	105/7206	7.8000768736e-08
ko05030	Cocaine addiction	31/1189	73/7206	1.23234476771e-07
ko04360	Axon guidance	70/1189	233/7206	2.00691059173e-07
ko04971	Gastric acid secretion	37/1189	98/7206	3.11880760332e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	30/1189	74/7206	6.62972042549e-07
ko04060	Cytokine-cytokine receptor interaction	9/1189	191/7206	8.33863768629e-07
ko03013	RNA transport	7/1189	166/7206	1.27099545658e-06
ko05203	Viral carcinogenesis	19/1189	277/7206	1.98370113218e-06
ko04966	Collecting duct acid secretion	15/1189	26/7206	2.12416654846e-06
ko05322	Systemic lupus erythematosus	6/1189	151/7206	2.22329419628e-06
ko05168	Herpes simplex infection	9/1189	182/7206	2.34076673262e-06
ko04621	NOD-like receptor signaling pathway	7/1189	157/7206	5.61534890956e-06
ko04141	Protein processing in endoplasmic reticulum	10/1189	184/7206	7.1385422151e-06
ko04070	Phosphatidylinositol signaling system	38/1189	112/7206	7.41659505753e-06
ko04120	Ubiquitin mediated proteolysis	6/1189	138/7206	1.39712273769e-05
ko04514	Cell adhesion molecules (CAMs)	41/1189	130/7206	2.0567652885e-05
ko04072	Phospholipase D signaling pathway	56/1189	197/7206	2.24800991625e-05
ko04740	Olfactory transduction	29/1189	80/7206	2.25709337929e-05
ko04924	Renin secretion	30/1189	86/7206	2.69919329494e-05
ko04972	Pancreatic secretion	36/1189	111/7206	2.77484202618e-05
ko04010	MAPK signaling pathway	82/1189	321/7206	2.84744845223e-05
ko05164	Influenza A	10/1189	167/7206	5.2800242223e-05
ko04110	Cell cycle	8/1189	145/7206	9.77340722514e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1189	79/7206	0.000100691056476
ko05110	Vibrio cholerae infection	23/1189	63/7206	0.000105722865198
ko04745	Phototransduction - fly	16/1189	38/7206	0.000161469437804
ko03008	Ribosome biogenesis in eukaryotes	2/1189	79/7206	0.000174375577003
ko05140	Leishmaniasis	2/1189	75/7206	0.000250298688
ko04612	Antigen processing and presentation	2/1189	77/7206	0.000267465917524
ko04730	Long-term depression	26/1189	78/7206	0.000291718815089
ko04976	Bile secretion	26/1189	80/7206	0.000377477473361
ko04260	Cardiac muscle contraction	30/1189	98/7206	0.000490121868921
ko04014	Ras signaling pathway	68/1189	279/7206	0.000529643994012
ko05205	Proteoglycans in cancer	25/1189	271/7206	0.000593021993257
ko04371	Apelin signaling pathway	47/1189	177/7206	0.000638363096404
ko04610	Complement and coagulation cascades	3/1189	79/7206	0.000705760027922
ko05414	Dilated cardiomyopathy	33/1189	112/7206	0.00070621176537
ko04750	Inflammatory mediator regulation of TRP channels	35/1189	122/7206	0.000757025445703
ko00520	Amino sugar and nucleotide sugar metabolism	1/1189	55/7206	0.000850276290102
ko00480	Glutathione metabolism	1/1189	55/7206	0.000850276290102
ko04540	Gap junction	36/1189	128/7206	0.00101852728852
ko04961	Endocrine and other factor-regulated calcium reabsorption	20/1189	59/7206	0.00110318354781
ko04915	Estrogen signaling pathway	36/1189	131/7206	0.00124614160631
ko04710	Circadian rhythm	16/1189	43/7206	0.00126719090127
ko04064	NF-kappa B signaling pathway	5/1189	96/7206	0.00127235268273
ko04964	Proximal tubule bicarbonate reclamation	12/1189	29/7206	0.00127978898088
ko04922	Glucagon signaling pathway	35/1189	128/7206	0.00165015745666
ko05161	Hepatitis B	14/1189	173/7206	0.00172967562292
ko05162	Measles	8/1189	120/7206	0.00182223274383
ko00590	Arachidonic acid metabolism	1/1189	52/7206	0.00203487688366
ko04930	Type II diabetes mellitus	18/1189	54/7206	0.00247926486623
ko04923	Regulation of lipolysis in adipocytes	23/1189	77/7206	0.0030080609558
ko05169	Epstein-Barr virus infection	19/1189	206/7206	0.003053645169
ko04146	Peroxisome	5/1189	89/7206	0.00359463172307
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1189	14/7206	0.00383822780112
ko05144	Malaria	1/1189	45/7206	0.00439151805457
ko00071	Fatty acid degradation	1/1189	45/7206	0.00439151805457
ko03420	Nucleotide excision repair	1/1189	46/7206	0.00441086755243
ko04626	Plant-pathogen interaction	8/1189	18/7206	0.00495475089808
ko04657	IL-17 signaling pathway	5/1189	87/7206	0.00512263310486
ko05321	Inflammatory bowel disease (IBD)	2/1189	56/7206	0.00575333947134
ko00240	Pyrimidine metabolism	8/1189	110/7206	0.00623494169578
ko03022	Basal transcription factors	1/1189	44/7206	0.00673623446605
ko05131	Shigellosis	5/1189	82/7206	0.00689620332377
ko04510	Focal adhesion	25/1189	240/7206	0.00791682859335
ko04630	Jak-STAT signaling pathway	11/1189	132/7206	0.00884570403147
ko04330	Notch signaling pathway	3/1189	62/7206	0.00918752914769
ko04622	RIG-I-like receptor signaling pathway	3/1189	62/7206	0.00918752914769
ko05166	HTLV-I infection	33/1189	292/7206	0.0125855253336
ko05133	Pertussis	6/1189	87/7206	0.0127827297648
ko05231	Choline metabolism in cancer	33/1189	134/7206	0.0134829114863
ko00330	Arginine and proline metabolism	3/1189	61/7206	0.0137124070864
ko05410	Hypertrophic cardiomyopathy (HCM)	26/1189	100/7206	0.0140715565613
ko00630	Glyoxylate and dicarboxylate metabolism	1/1189	38/7206	0.0147813196452
ko05145	Toxoplasmosis	11/1189	126/7206	0.0151639904838
ko03018	RNA degradation	6/1189	84/7206	0.0173507826405
ko05219	Bladder cancer	2/1189	48/7206	0.0176290785161
ko04115	p53 signaling pathway	5/1189	74/7206	0.0182418280821
ko05016	Huntington's disease	23/1189	215/7206	0.0193692056857
ko04973	Carbohydrate digestion and absorption	13/1189	42/7206	0.0194170201949
ko00562	Inositol phosphate metabolism	23/1189	89/7206	0.0212917609796
ko00310	Lysine degradation	5/1189	73/7206	0.0251977667405
ko04658	Th1 and Th2 cell differentiation	8/1189	96/7206	0.0266748533621
ko04350	TGF-beta signaling pathway	9/1189	103/7206	0.0318023903003
ko04217	Necroptosis	19/1189	178/7206	0.0318152551306
ko04210	Apoptosis	19/1189	180/7206	0.0320619455099
ko05120	Epithelial cell signaling in Helicobacter pylori infection	23/1189	92/7206	0.0333650533128
ko00860	Porphyrin and chlorophyll metabolism	1/1189	34/7206	0.0337315340913
ko04912	GnRH signaling pathway	29/1189	122/7206	0.0358310480169
ko05200	Pathways in cancer	65/1189	492/7206	0.0438854722766
ko00512	Mucin type O-glycan biosynthesis	9/1189	29/7206	0.0440047126018
ko04270	Vascular smooth muscle contraction	35/1189	154/7206	0.0472691237612
ko04114	Oocyte meiosis	32/1189	139/7206	0.0487311841246
ko05340	Primary immunodeficiency	1/1189	30/7206	0.0489735727819
ko04711	Circadian rhythm - fly	5/1189	13/7206	0.0490966322157