ko pathway ratio_in_study ratio_in_pop p_value ko04724 Glutamatergic synapse 28/275 152/7206 2.07336165548e-12 ko04080 Neuroactive ligand-receptor interaction 44/275 423/7206 6.33751586726e-10 ko05033 Nicotine addiction 15/275 56/7206 1.44274019737e-09 ko04727 GABAergic synapse 19/275 110/7206 2.5546114451e-08 ko04720 Long-term potentiation 18/275 99/7206 2.62328299014e-08 ko04713 Circadian entrainment 21/275 136/7206 3.59963823649e-08 ko04723 Retrograde endocannabinoid signaling 23/275 175/7206 1.71503029413e-07 ko04911 Insulin secretion 18/275 117/7206 3.72435849098e-07 ko04020 Calcium signaling pathway 28/275 265/7206 7.98488820702e-07 ko04070 Phosphatidylinositol signaling system 17/275 112/7206 9.63588585501e-07 ko04728 Dopaminergic synapse 22/275 185/7206 1.82418378307e-06 ko04970 Salivary secretion 15/275 95/7206 2.55852535255e-06 ko04921 Oxytocin signaling pathway 23/275 209/7206 4.06490202979e-06 ko05032 Morphine addiction 15/275 110/7206 1.62744112612e-05 ko04726 Serotonergic synapse 16/275 137/7206 6.03291343963e-05 ko00562 Inositol phosphate metabolism 12/275 89/7206 0.000128871778469 ko05031 Amphetamine addiction 12/275 91/7206 0.000160027386903 ko04730 Long-term depression 11/275 78/7206 0.000163526699785 ko04925 Aldosterone synthesis and secretion 13/275 105/7206 0.000164464488667 ko04972 Pancreatic secretion 13/275 111/7206 0.000288335421167 ko04261 Adrenergic signaling in cardiomyocytes 19/275 205/7206 0.000290652669776 ko04742 Taste transduction 9/275 61/7206 0.00045674711362 ko04725 Cholinergic synapse 15/275 160/7206 0.00111745774821 ko04024 cAMP signaling pathway 22/275 279/7206 0.00113167940506 ko04260 Cardiac muscle contraction 11/275 98/7206 0.00119909253788 ko04924 Renin secretion 10/275 86/7206 0.00151767475974 ko04022 cGMP-PKG signaling pathway 18/275 216/7206 0.00165789783635 ko05014 Amyotrophic lateral sclerosis (ALS) 9/275 74/7206 0.00188913302108 ko04745 Phototransduction - fly 6/275 38/7206 0.00288380836506 ko04721 Synaptic vesicle cycle 9/275 80/7206 0.00324904538884 ko04010 MAPK signaling pathway 23/275 321/7206 0.00395306450077 ko04971 Gastric acid secretion 10/275 98/7206 0.00402144580975 ko04014 Ras signaling pathway 20/275 279/7206 0.00602130220156 ko05203 Viral carcinogenesis 3/275 277/7206 0.00984178491187 ko05202 Transcriptional misregulation in cancer 1/275 188/7206 0.0105845561002 ko04740 Olfactory transduction 8/275 80/7206 0.0109129679488 ko04072 Phospholipase D signaling pathway 15/275 197/7206 0.0119798252496 ko05010 Alzheimer's disease 15/275 202/7206 0.0133742678334 ko00604 Glycosphingolipid biosynthesis - ganglio series 3/275 14/7206 0.0146385416727 ko04514 Cell adhesion molecules (CAMs) 11/275 130/7206 0.0167064925567 ko05231 Choline metabolism in cancer 11/275 134/7206 0.0183478566991 ko05164 Influenza A 1/275 167/7206 0.0221049917681 ko00010 Glycolysis / Gluconeogenesis 7/275 74/7206 0.0222235052382 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 7/275 79/7206 0.0305274622913 ko05110 Vibrio cholerae infection 6/275 63/7206 0.0322457610698 ko02025 Biofilm formation - Pseudomonas aeruginosa 1/275 1/7206 0.0381626422426 ko00680 Methane metabolism 4/275 34/7206 0.0391644104253 ko03040 Spliceosome 1/275 145/7206 0.0454889352452 ko04371 Apelin signaling pathway 12/275 177/7206 0.0455679312907