ko pathway ratio_in_study ratio_in_pop p_value ko04080 Neuroactive ligand-receptor interaction 59/417 423/7206 1.09232692237e-10 ko04724 Glutamatergic synapse 29/417 152/7206 8.14270055248e-09 ko04721 Synaptic vesicle cycle 20/417 80/7206 1.58337214284e-08 ko05033 Nicotine addiction 16/417 56/7206 5.80946333052e-08 ko04728 Dopaminergic synapse 30/417 185/7206 2.08903756428e-07 ko04727 GABAergic synapse 22/417 110/7206 2.28478704565e-07 ko04024 cAMP signaling pathway 39/417 279/7206 2.31528357713e-07 ko04964 Proximal tubule bicarbonate reclamation 11/417 29/7206 2.86576188477e-07 ko04911 Insulin secretion 22/417 117/7206 7.02529922837e-07 ko04725 Cholinergic synapse 25/417 160/7206 4.4169549305e-06 ko04726 Serotonergic synapse 22/417 137/7206 1.06391856807e-05 ko05032 Morphine addiction 19/417 110/7206 1.47295472543e-05 ko04972 Pancreatic secretion 19/417 111/7206 1.68407311916e-05 ko04744 Phototransduction 10/417 36/7206 2.46453157634e-05 ko04713 Circadian entrainment 21/417 136/7206 3.10864334374e-05 ko05031 Amphetamine addiction 16/417 91/7206 5.56586836828e-05 ko05030 Cocaine addiction 14/417 73/7206 6.0474474515e-05 ko04020 Calcium signaling pathway 32/417 265/7206 6.91986815692e-05 ko04723 Retrograde endocannabinoid signaling 24/417 175/7206 8.89988578085e-05 ko04970 Salivary secretion 15/417 95/7206 0.000327042475903 ko04921 Oxytocin signaling pathway 25/417 209/7206 0.000449645473951 ko00680 Methane metabolism 8/417 34/7206 0.000562505472906 ko04976 Bile secretion 13/417 80/7206 0.000609529794189 ko00965 Betalain biosynthesis 3/417 4/7206 0.000736713938239 ko05205 Proteoglycans in cancer 4/417 271/7206 0.000750950670191 ko05231 Choline metabolism in cancer 18/417 134/7206 0.000979381329888 ko00010 Glycolysis / Gluconeogenesis 12/417 74/7206 0.000999203429187 ko00030 Pentose phosphate pathway 7/417 32/7206 0.00196676638846 ko04742 Taste transduction 10/417 61/7206 0.00238562221975 ko04072 Phospholipase D signaling pathway 22/417 197/7206 0.00279331185478 ko04217 Necroptosis 2/417 178/7206 0.00298745264944 ko05203 Viral carcinogenesis 6/417 277/7206 0.00544190705401 ko03013 RNA transport 2/417 166/7206 0.00618598729248 ko04070 Phosphatidylinositol signaling system 14/417 112/7206 0.00619452944207 ko04961 Endocrine and other factor-regulated calcium reabsorption 9/417 59/7206 0.0063493853089 ko04960 Aldosterone-regulated sodium reabsorption 7/417 41/7206 0.00838757139816 ko04261 Adrenergic signaling in cardiomyocytes 21/417 205/7206 0.00933650143356 ko01230 Biosynthesis of amino acids 11/417 85/7206 0.00946649247847 ko05166 HTLV-I infection 7/417 292/7206 0.00973950436092 ko04710 Circadian rhythm 7/417 43/7206 0.010887556147 ko04514 Cell adhesion molecules (CAMs) 15/417 130/7206 0.0115306095632 ko04260 Cardiac muscle contraction 12/417 98/7206 0.0133732659895 ko04218 Cellular senescence 3/417 177/7206 0.0134159678794 ko00564 Glycerophospholipid metabolism 12/417 99/7206 0.0140616494592 ko05169 Epstein-Barr virus infection 4/417 206/7206 0.0141292044361 ko04966 Collecting duct acid secretion 5/417 26/7206 0.0151826919486 ko05162 Measles 1/417 120/7206 0.0154115987858 ko00950 Isoquinoline alkaloid biosynthesis 3/417 10/7206 0.0170141436856 ko04110 Cell cycle 2/417 145/7206 0.0176137684764 ko05164 Influenza A 3/417 167/7206 0.0184529978306 ko00471 D-Glutamine and D-glutamate metabolism 2/417 4/7206 0.0185405225256 ko04925 Aldosterone synthesis and secretion 12/417 105/7206 0.0195322282839 ko05200 Pathways in cancer 17/417 492/7206 0.0209046622134 ko02010 ABC transporters 6/417 39/7206 0.0232855869525 ko04510 Focal adhesion 6/417 240/7206 0.0235427624796 ko04120 Ubiquitin mediated proteolysis 2/417 138/7206 0.0248282364446 ko05230 Central carbon metabolism in cancer 10/417 81/7206 0.0255968758768 ko04611 Platelet activation 3/417 163/7206 0.0257413321557 ko05110 Vibrio cholerae infection 8/417 63/7206 0.0278373650806 ko04971 Gastric acid secretion 11/417 98/7206 0.0282878021833 ko04918 Thyroid hormone synthesis 10/417 86/7206 0.0318011814115 ko00051 Fructose and mannose metabolism 6/417 42/7206 0.032402807849 ko04151 PI3K-Akt signaling pathway 13/417 390/7206 0.0333321281953 ko05168 Herpes simplex infection 4/417 182/7206 0.0348506960862 ko04940 Type I diabetes mellitus 5/417 32/7206 0.0350377284501 ko04711 Circadian rhythm - fly 3/417 13/7206 0.0356446590416 ko04621 NOD-like receptor signaling pathway 3/417 157/7206 0.0357429754615 ko04022 cGMP-PKG signaling pathway 20/417 216/7206 0.0365653027136 ko00350 Tyrosine metabolism 5/417 33/7206 0.0394064653487 ko00604 Glycosphingolipid biosynthesis - ganglio series 3/417 14/7206 0.043469653636 ko04730 Long-term depression 9/417 78/7206 0.0446062232224