ko pathway ratio_in_study ratio_in_pop p_value ko04721 Synaptic vesicle cycle 14/165 80/7206 2.5511042697e-09 ko05033 Nicotine addiction 11/165 56/7206 3.9707500873e-08 ko04080 Neuroactive ligand-receptor interaction 29/165 423/7206 7.57052639855e-08 ko04724 Glutamatergic synapse 16/165 152/7206 3.18914437684e-07 ko04911 Insulin secretion 14/165 117/7206 3.73309822106e-07 ko04713 Circadian entrainment 14/165 136/7206 2.36639484828e-06 ko04728 Dopaminergic synapse 16/165 185/7206 4.46462092228e-06 ko04727 GABAergic synapse 12/165 110/7206 7.01479844718e-06 ko05032 Morphine addiction 11/165 110/7206 3.90857096355e-05 ko04961 Endocrine and other factor-regulated calcium reabsorption 8/165 59/7206 5.2346720377e-05 ko04024 cAMP signaling pathway 18/165 279/7206 6.34151701549e-05 ko04723 Retrograde endocannabinoid signaling 13/165 175/7206 0.000174904135857 ko05014 Amyotrophic lateral sclerosis (ALS) 8/165 74/7206 0.000265932052221 ko04725 Cholinergic synapse 12/165 160/7206 0.000285489537527 ko04970 Salivary secretion 9/165 95/7206 0.000302769583324 ko04964 Proximal tubule bicarbonate reclamation 5/165 29/7206 0.000450637921435 ko04940 Type I diabetes mellitus 5/165 32/7206 0.000722951758482 ko04972 Pancreatic secretion 9/165 111/7206 0.000953188624465 ko05031 Amphetamine addiction 8/165 91/7206 0.00107929780166 ko04015 Rap1 signaling pathway 15/165 278/7206 0.00169971564523 ko04971 Gastric acid secretion 8/165 98/7206 0.00174598367778 ko04720 Long-term potentiation 8/165 99/7206 0.00186320768467 ko04978 Mineral absorption 5/165 40/7206 0.00203850049451 ko04960 Aldosterone-regulated sodium reabsorption 5/165 41/7206 0.00227933316205 ko04261 Adrenergic signaling in cardiomyocytes 12/165 205/7206 0.00252705845675 ko04360 Axon guidance 13/165 233/7206 0.00257496013287 ko04514 Cell adhesion molecules (CAMs) 9/165 130/7206 0.00287076836352 ko04726 Serotonergic synapse 9/165 137/7206 0.00407816829918 ko02024 Quorum sensing 3/165 15/7206 0.00438009222399 ko05030 Cocaine addiction 6/165 73/7206 0.00631840968262 ko04730 Long-term depression 6/165 78/7206 0.00868452886822 ko04540 Gap junction 8/165 128/7206 0.00891385756763 ko04924 Renin secretion 6/165 86/7206 0.0136986222687 ko04918 Thyroid hormone synthesis 6/165 86/7206 0.0136986222687 ko05110 Vibrio cholerae infection 5/165 63/7206 0.0143025426646 ko04973 Carbohydrate digestion and absorption 4/165 42/7206 0.0150853799981 ko04216 Ferroptosis 4/165 44/7206 0.0176648509495 ko05120 Epithelial cell signaling in Helicobacter pylori infection 6/165 92/7206 0.0185886472041 ko04966 Collecting duct acid secretion 3/165 26/7206 0.0208291924298 ko02025 Biofilm formation - Pseudomonas aeruginosa 1/165 1/7206 0.0228975853456 ko04145 Phagosome 8/165 162/7206 0.0322069846154 ko04022 cGMP-PKG signaling pathway 10/165 216/7206 0.0324674764122 ko04925 Aldosterone synthesis and secretion 6/165 105/7206 0.0330021280034 ko00430 Taurine and hypotaurine metabolism 2/165 14/7206 0.0395944910656