ko pathway ratio_in_study ratio_in_pop p_value ko04060 Cytokine-cytokine receptor interaction 31/204 191/7206 1.03808471259e-15 ko05340 Primary immunodeficiency 14/204 30/7206 1.32913796468e-14 ko05164 Influenza A 27/204 167/7206 9.53240302276e-14 ko05168 Herpes simplex infection 28/204 182/7206 1.16109792121e-13 ko04621 NOD-like receptor signaling pathway 26/204 157/7206 1.58275516242e-13 ko04217 Necroptosis 27/204 178/7206 4.71537302622e-13 ko05162 Measles 22/204 120/7206 1.5792219204e-12 ko04380 Osteoclast differentiation 23/204 134/7206 2.02689868609e-12 ko04064 NF-kappa B signaling pathway 19/204 96/7206 1.38317922843e-11 ko04650 Natural killer cell mediated cytotoxicity 19/204 97/7206 1.67783935972e-11 ko04620 Toll-like receptor signaling pathway 19/204 100/7206 2.95114304987e-11 ko05145 Toxoplasmosis 20/204 126/7206 2.636681553e-10 ko04659 Th17 cell differentiation 18/204 106/7206 6.9555093562e-10 ko05152 Tuberculosis 23/204 187/7206 2.10884822742e-09 ko04612 Antigen processing and presentation 15/204 77/7206 2.7012386394e-09 ko05321 Inflammatory bowel disease (IBD) 13/204 56/7206 3.31582364678e-09 ko05320 Autoimmune thyroid disease 10/204 29/7206 3.32536283557e-09 ko05330 Allograft rejection 9/204 24/7206 8.86410617515e-09 ko05161 Hepatitis B 21/204 173/7206 1.40509962454e-08 ko05167 Kaposi's sarcoma-associated herpesvirus infection 22/204 191/7206 1.65794699533e-08 ko05140 Leishmaniasis 14/204 75/7206 1.66549622676e-08 ko04630 Jak-STAT signaling pathway 18/204 132/7206 2.58639545219e-08 ko04660 T cell receptor signaling pathway 17/204 124/7206 5.92767461582e-08 ko04658 Th1 and Th2 cell differentiation 15/204 96/7206 6.23072818205e-08 ko04622 RIG-I-like receptor signaling pathway 12/204 62/7206 1.19459597129e-07 ko05332 Graft-versus-host disease 7/204 18/7206 3.21190635216e-07 ko04672 Intestinal immune network for IgA production 9/204 37/7206 6.12425225474e-07 ko04623 Cytosolic DNA-sensing pathway 9/204 41/7206 1.56318515608e-06 ko04940 Type I diabetes mellitus 8/204 32/7206 2.10845523088e-06 ko05142 Chagas disease (American trypanosomiasis) 15/204 130/7206 3.44353305371e-06 ko04062 Chemokine signaling pathway 19/204 201/7206 3.53485509516e-06 ko04668 TNF signaling pathway 14/204 120/7206 6.46578170361e-06 ko04210 Apoptosis 17/204 180/7206 1.19330088622e-05 ko05160 Hepatitis C 15/204 153/7206 2.54329364882e-05 ko05133 Pertussis 11/204 87/7206 3.04113863025e-05 ko04662 B cell receptor signaling pathway 11/204 88/7206 3.39062393738e-05 ko05310 Asthma 5/204 17/7206 8.11610131265e-05 ko03050 Proteasome 8/204 54/7206 0.000122143183584 ko04145 Phagosome 14/204 162/7206 0.00018703591973 ko04664 Fc epsilon RI signaling pathway 9/204 77/7206 0.000298027355837 ko04640 Hematopoietic cell lineage 8/204 64/7206 0.000407823527306 ko05150 Staphylococcus aureus infection 6/204 36/7206 0.00045804202114 ko05166 HTLV-I infection 19/204 292/7206 0.000770242632405 ko05144 Malaria 6/204 45/7206 0.00155020286711 ko05169 Epstein-Barr virus infection 14/204 206/7206 0.00205344432751 ko04080 Neuroactive ligand-receptor interaction 3/204 423/7206 0.00355679673174 ko05323 Rheumatoid arthritis 8/204 89/7206 0.00356243316839 ko05416 Viral myocarditis 6/204 55/7206 0.00436664234028 ko05134 Legionellosis 7/204 74/7206 0.00475226017665 ko04611 Platelet activation 11/204 163/7206 0.00640083288471 ko04610 Complement and coagulation cascades 7/204 79/7206 0.00680068408616 ko04666 Fc gamma R-mediated phagocytosis 9/204 122/7206 0.00755786114671 ko04670 Leukocyte transendothelial migration 10/204 151/7206 0.0103968258354 ko05120 Epithelial cell signaling in Helicobacter pylori infection 7/204 92/7206 0.0151286532422 ko05146 Amoebiasis 7/204 99/7206 0.0218152207601 ko05131 Shigellosis 6/204 82/7206 0.0282284708986 ko00966 Glucosinolate biosynthesis 1/204 1/7206 0.0283097418817 ko04514 Cell adhesion molecules (CAMs) 8/204 130/7206 0.0308436107494 ko00511 Other glycan degradation 3/204 26/7206 0.0360153790516