ko pathway ratio_in_study ratio_in_pop p_value ko04721 Synaptic vesicle cycle 17/320 80/7206 5.2781723807e-08 ko05110 Vibrio cholerae infection 15/320 63/7206 6.53671676263e-08 ko04966 Collecting duct acid secretion 10/320 26/7206 7.30614846389e-08 ko04911 Insulin secretion 19/320 117/7206 7.68267523647e-07 ko04727 GABAergic synapse 18/320 110/7206 1.34535752322e-06 ko04713 Circadian entrainment 20/320 136/7206 1.9830872572e-06 ko04724 Glutamatergic synapse 21/320 152/7206 3.08000972867e-06 ko00010 Glycolysis / Gluconeogenesis 14/320 74/7206 3.54855137601e-06 ko05120 Epithelial cell signaling in Helicobacter pylori infection 15/320 92/7206 1.08588803659e-05 ko00190 Oxidative phosphorylation 18/320 127/7206 1.10311552761e-05 ko04725 Cholinergic synapse 20/320 160/7206 2.429600977e-05 ko04145 Phagosome 20/320 162/7206 2.91810786458e-05 ko04921 Oxytocin signaling pathway 23/320 209/7206 4.79859033783e-05 ko04925 Aldosterone synthesis and secretion 15/320 105/7206 5.46097864579e-05 ko04970 Salivary secretion 14/320 95/7206 6.83049258174e-05 ko01230 Biosynthesis of amino acids 13/320 85/7206 8.38567247913e-05 ko04626 Plant-pathogen interaction 6/320 18/7206 8.63133596355e-05 ko00680 Methane metabolism 8/320 34/7206 9.134617779e-05 ko04971 Gastric acid secretion 14/320 98/7206 9.66492190669e-05 ko04720 Long-term potentiation 14/320 99/7206 0.000108135860342 ko04022 cGMP-PKG signaling pathway 23/320 216/7206 0.000127384354254 ko05323 Rheumatoid arthritis 13/320 89/7206 0.00013596842863 ko04024 cAMP signaling pathway 27/320 279/7206 0.000137828576475 ko04270 Vascular smooth muscle contraction 18/320 154/7206 0.000149530551089 ko04922 Glucagon signaling pathway 16/320 128/7206 0.000158695576859 ko05031 Amphetamine addiction 13/320 91/7206 0.000171149946638 ko04745 Phototransduction - fly 8/320 38/7206 0.000210651632176 ko04261 Adrenergic signaling in cardiomyocytes 21/320 205/7206 0.000360664910397 ko04080 Neuroactive ligand-receptor interaction 34/320 423/7206 0.000603185845864 ko05032 Morphine addiction 13/320 110/7206 0.00110842239806 ko04723 Retrograde endocannabinoid signaling 17/320 175/7206 0.00222262858304 ko00051 Fructose and mannose metabolism 7/320 42/7206 0.00224867767946 ko04371 Apelin signaling pathway 17/320 177/7206 0.00244136809549 ko04060 Cytokine-cytokine receptor interaction 1/320 191/7206 0.00352314165741 ko04070 Phosphatidylinositol signaling system 12/320 112/7206 0.00390612657231 ko04726 Serotonergic synapse 14/320 137/7206 0.0048098875492 ko04728 Dopaminergic synapse 17/320 185/7206 0.00539524394449 ko04020 Calcium signaling pathway 22/320 265/7206 0.00539547793991 ko05164 Influenza A 1/320 167/7206 0.00710027063187 ko04730 Long-term depression 9/320 78/7206 0.00735698024044 ko04710 Circadian rhythm 6/320 43/7206 0.0111341510905 ko05033 Nicotine addiction 7/320 56/7206 0.011389415088 ko04924 Renin secretion 9/320 86/7206 0.0136339130914 ko05322 Systemic lupus erythematosus 1/320 151/7206 0.0150014137404 ko00620 Pyruvate metabolism 6/320 46/7206 0.0153144340059 ko05014 Amyotrophic lateral sclerosis (ALS) 8/320 74/7206 0.0162988212501 ko04014 Ras signaling pathway 21/320 279/7206 0.0166483692439 ko05166 HTLV-I infection 5/320 292/7206 0.0190094987409 ko00430 Taurine and hypotaurine metabolism 3/320 14/7206 0.02192972944 ko03040 Spliceosome 1/320 145/7206 0.0222109393084 ko01040 Biosynthesis of unsaturated fatty acids 4/320 25/7206 0.0230745710732 ko04066 HIF-1 signaling pathway 11/320 123/7206 0.0239879063598 ko05224 Breast cancer 2/320 174/7206 0.0248223930081 ko05168 Herpes simplex infection 2/320 182/7206 0.0259863107035 ko05230 Central carbon metabolism in cancer 8/320 81/7206 0.0266853501075 ko04540 Gap junction 11/320 128/7206 0.0293856817735 ko04972 Pancreatic secretion 10/320 111/7206 0.031437358212 ko04916 Melanogenesis 12/320 142/7206 0.0351305369079 ko05169 Epstein-Barr virus infection 3/320 206/7206 0.0368134012725 ko04964 Proximal tubule bicarbonate reclamation 4/320 29/7206 0.0377433909685 ko04260 Cardiac muscle contraction 9/320 98/7206 0.0407804177697 ko02025 Biofilm formation - Pseudomonas aeruginosa 1/320 1/7206 0.0444074382458 ko04961 Endocrine and other factor-regulated calcium reabsorption 6/320 59/7206 0.04578371979 ko03010 Ribosome 1/320 129/7206 0.0471372649969 ko05152 Tuberculosis 14/320 187/7206 0.0472960569994 ko04621 NOD-like receptor signaling pathway 2/320 157/7206 0.048688501252 ko00592 alpha-Linolenic acid metabolism 3/320 19/7206 0.0496094524907