ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	192/1177	423/7206	4.43483337123e-48
ko04724	Glutamatergic synapse	88/1177	152/7206	5.05014635492e-32
ko05033	Nicotine addiction	46/1177	56/7206	1.992266677e-27
ko04721	Synaptic vesicle cycle	53/1177	80/7206	1.20539551764e-23
ko04713	Circadian entrainment	72/1177	136/7206	3.82667169009e-23
ko05032	Morphine addiction	63/1177	110/7206	7.76067270488e-23
ko04727	GABAergic synapse	61/1177	110/7206	3.75177185698e-21
ko04728	Dopaminergic synapse	83/1177	185/7206	2.02758295186e-20
ko04725	Cholinergic synapse	75/1177	160/7206	6.23615641262e-20
ko04723	Retrograde endocannabinoid signaling	75/1177	175/7206	3.66103808915e-17
ko04742	Taste transduction	39/1177	61/7206	6.55168411896e-17
ko04024	cAMP signaling pathway	98/1177	279/7206	5.02810214778e-15
ko04911	Insulin secretion	54/1177	117/7206	2.53260254574e-14
ko04921	Oxytocin signaling pathway	79/1177	209/7206	2.73258600453e-14
ko04020	Calcium signaling pathway	91/1177	265/7206	2.5615285143e-13
ko04726	Serotonergic synapse	58/1177	137/7206	2.91164768034e-13
ko04720	Long-term potentiation	45/1177	99/7206	7.30307344966e-12
ko03040	Spliceosome	1/1177	145/7206	1.95321084154e-10
ko05031	Amphetamine addiction	40/1177	91/7206	3.82125099311e-10
ko04261	Adrenergic signaling in cardiomyocytes	69/1177	205/7206	6.11510000868e-10
ko04360	Axon guidance	76/1177	233/7206	6.41411576611e-10
ko04970	Salivary secretion	40/1177	95/7206	1.82060984028e-09
ko04744	Phototransduction	21/1177	36/7206	1.1781053805e-08
ko05168	Herpes simplex infection	6/1177	182/7206	3.6135301866e-08
ko05203	Viral carcinogenesis	16/1177	277/7206	1.18489703609e-07
ko04971	Gastric acid secretion	37/1177	98/7206	2.47780818534e-07
ko04740	Olfactory transduction	32/1177	80/7206	3.20187920644e-07
ko03013	RNA transport	6/1177	166/7206	3.50225077964e-07
ko04120	Ubiquitin mediated proteolysis	4/1177	138/7206	6.34383280845e-07
ko04621	NOD-like receptor signaling pathway	6/1177	157/7206	1.63672873466e-06
ko04925	Aldosterone synthesis and secretion	37/1177	105/7206	1.77341172122e-06
ko04966	Collecting duct acid secretion	15/1177	26/7206	1.85975839449e-06
ko04060	Cytokine-cytokine receptor interaction	10/1177	191/7206	3.66750917619e-06
ko05164	Influenza A	8/1177	167/7206	6.240507581e-06
ko05030	Cocaine addiction	28/1177	73/7206	6.6994059953e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1177	74/7206	8.03517541183e-06
ko04022	cGMP-PKG signaling pathway	61/1177	216/7206	8.60357340118e-06
ko04010	MAPK signaling pathway	83/1177	321/7206	9.03848208498e-06
ko04540	Gap junction	41/1177	128/7206	9.26436965421e-06
ko04514	Cell adhesion molecules (CAMs)	41/1177	130/7206	1.87268399946e-05
ko04260	Cardiac muscle contraction	33/1177	98/7206	2.24692366621e-05
ko04141	Protein processing in endoplasmic reticulum	11/1177	184/7206	2.82116199687e-05
ko05322	Systemic lupus erythematosus	8/1177	151/7206	4.97866302012e-05
ko05169	Epstein-Barr virus infection	14/1177	206/7206	5.13178691301e-05
ko04064	NF-kappa B signaling pathway	3/1177	96/7206	7.24291361847e-05
ko04730	Long-term depression	27/1177	78/7206	7.26424111269e-05
ko04972	Pancreatic secretion	35/1177	111/7206	7.3009308326e-05
ko04070	Phosphatidylinositol signaling system	35/1177	112/7206	8.09785815929e-05
ko04924	Renin secretion	29/1177	86/7206	8.68893244788e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1177	79/7206	8.74018007429e-05
ko04110	Cell cycle	8/1177	145/7206	9.81031293854e-05
ko04745	Phototransduction - fly	16/1177	38/7206	0.00014274588145
ko03008	Ribosome biogenesis in eukaryotes	2/1177	79/7206	0.000171659902552
ko04014	Ras signaling pathway	69/1177	279/7206	0.000254287538103
ko04976	Bile secretion	26/1177	80/7206	0.000341310256923
ko05140	Leishmaniasis	2/1177	75/7206	0.000395931088136
ko05110	Vibrio cholerae infection	22/1177	63/7206	0.00040996559551
ko00604	Glycosphingolipid biosynthesis - ganglio series	8/1177	14/7206	0.000588243842967
ko05162	Measles	7/1177	120/7206	0.000703298764986
ko05205	Proteoglycans in cancer	25/1177	271/7206	0.000767840884157
ko04961	Endocrine and other factor-regulated calcium reabsorption	20/1177	59/7206	0.00103519680378
ko05414	Dilated cardiomyopathy	32/1177	112/7206	0.00109200050152
ko04072	Phospholipase D signaling pathway	50/1177	197/7206	0.00115255452755
ko04750	Inflammatory mediator regulation of TRP channels	34/1177	122/7206	0.0011665805541
ko04964	Proximal tubule bicarbonate reclamation	12/1177	29/7206	0.00116709670258
ko04146	Peroxisome	4/1177	89/7206	0.00123489807589
ko00480	Glutathione metabolism	1/1177	55/7206	0.0013609955456
ko04612	Antigen processing and presentation	3/1177	77/7206	0.00156899208048
ko04640	Hematopoietic cell lineage	2/1177	64/7206	0.00182065010362
ko00590	Arachidonic acid metabolism	1/1177	52/7206	0.0019981508444
ko05161	Hepatitis B	14/1177	173/7206	0.00234242996201
ko00240	Pyrimidine metabolism	7/1177	110/7206	0.0025771359618
ko04915	Estrogen signaling pathway	35/1177	131/7206	0.00258321057853
ko00330	Arginine and proline metabolism	2/1177	61/7206	0.00265299541839
ko05145	Toxoplasmosis	9/1177	126/7206	0.00327407948664
ko03420	Nucleotide excision repair	1/1177	46/7206	0.00441791477948
ko04626	Plant-pathogen interaction	8/1177	18/7206	0.00464536771619
ko04930	Type II diabetes mellitus	17/1177	54/7206	0.00496476404626
ko04371	Apelin signaling pathway	43/1177	177/7206	0.0053161898324
ko04916	Melanogenesis	36/1177	142/7206	0.00557710014671
ko05321	Inflammatory bowel disease (IBD)	2/1177	56/7206	0.00571529298806
ko04668	TNF signaling pathway	9/1177	120/7206	0.00590522693695
ko03022	Basal transcription factors	1/1177	44/7206	0.00668894044395
ko00071	Fatty acid degradation	1/1177	45/7206	0.0069846573587
ko01524	Platinum drug resistance	4/1177	76/7206	0.00710890695325
ko00280	Valine, leucine and isoleucine degradation	2/1177	54/7206	0.00847031349083
ko04622	RIG-I-like receptor signaling pathway	3/1177	62/7206	0.00923454903633
ko04214	Apoptosis - fly	4/1177	72/7206	0.00964489161724
ko00310	Lysine degradation	4/1177	73/7206	0.00985629864885
ko00140	Steroid hormone biosynthesis	1/1177	41/7206	0.00994757024456
ko00380	Tryptophan metabolism	2/1177	50/7206	0.0121079992502
ko04923	Regulation of lipolysis in adipocytes	21/1177	77/7206	0.0128082127113
ko04657	IL-17 signaling pathway	6/1177	87/7206	0.0128114994415
ko05133	Pertussis	6/1177	87/7206	0.0128114994415
ko04217	Necroptosis	17/1177	178/7206	0.0132534744452
ko05410	Hypertrophic cardiomyopathy (HCM)	26/1177	100/7206	0.0133767107119
ko03410	Base excision repair	1/1177	38/7206	0.0148791725044
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1177	40/7206	0.0156894667357
ko05418	Fluid shear stress and atherosclerosis	17/1177	173/7206	0.0165564785453
ko03018	RNA degradation	6/1177	84/7206	0.0174592299189
ko00260	Glycine, serine and threonine metabolism	2/1177	48/7206	0.0176016141377
ko04912	GnRH signaling pathway	30/1177	122/7206	0.0182150411488
ko05166	HTLV-I infection	33/1177	292/7206	0.0187554806469
ko04015	Rap1 signaling pathway	60/1177	278/7206	0.0201841473072
ko00982	Drug metabolism - cytochrome P450	1/1177	37/7206	0.0228662800525
ko05131	Shigellosis	6/1177	82/7206	0.0236341544485
ko05144	Malaria	2/1177	45/7206	0.025434726137
ko04115	p53 signaling pathway	5/1177	74/7206	0.0254622053222
ko00620	Pyruvate metabolism	2/1177	46/7206	0.0257328571519
ko00600	Sphingolipid metabolism	4/1177	63/7206	0.0261911210345
ko04210	Apoptosis	19/1177	180/7206	0.0319536331576
ko04350	TGF-beta signaling pathway	9/1177	103/7206	0.0319722681154
ko04062	Chemokine signaling pathway	44/1177	201/7206	0.03342297425
ko04658	Th1 and Th2 cell differentiation	8/1177	96/7206	0.0358060328565
ko04270	Vascular smooth muscle contraction	35/1177	154/7206	0.0358355241696
ko00983	Drug metabolism - other enzymes	2/1177	42/7206	0.0367538774412
ko00562	Inositol phosphate metabolism	22/1177	89/7206	0.041920547259
ko00512	Mucin type O-glycan biosynthesis	9/1177	29/7206	0.0421358941022
ko05231	Choline metabolism in cancer	31/1177	134/7206	0.0438233500849
ko05230	Central carbon metabolism in cancer	20/1177	81/7206	0.0486074953406
ko05340	Primary immunodeficiency	1/1177	30/7206	0.049342851322
ko04136	Autophagy - other	1/1177	31/7206	0.0493485760873
ko05034	Alcoholism	50/1177	238/7206	0.0499725501806