ko pathway ratio_in_study ratio_in_pop p_value ko04110 Cell cycle 36/461 145/7206 6.24048633024e-13 ko04111 Cell cycle - yeast 26/461 90/7206 2.84262748306e-11 ko04080 Neuroactive ligand-receptor interaction 2/461 423/7206 2.49337936543e-10 ko03440 Homologous recombination 15/461 41/7206 1.32876378749e-08 ko04113 Meiosis - yeast 18/461 70/7206 2.40040849257e-07 ko03030 DNA replication 13/461 38/7206 3.14091914855e-07 ko04520 Adherens junction 21/461 103/7206 1.6028944541e-06 ko04390 Hippo signaling pathway 29/461 188/7206 1.07470979819e-05 ko03460 Fanconi anemia pathway 13/461 51/7206 1.28054166106e-05 ko04530 Tight junction 32/461 228/7206 2.24254761526e-05 ko04330 Notch signaling pathway 13/461 62/7206 0.000116826507355 ko00240 Pyrimidine metabolism 18/461 110/7206 0.000188950599227 ko04013 MAPK signaling pathway - fly 18/461 115/7206 0.000334106430577 ko03040 Spliceosome 21/461 145/7206 0.000393509784605 ko03013 RNA transport 23/461 166/7206 0.000528314499896 ko04020 Calcium signaling pathway 5/461 265/7206 0.000781606821764 ko03018 RNA degradation 14/461 84/7206 0.000795597428587 ko05206 MicroRNAs in cancer 23/461 177/7206 0.000946137277 ko04391 Hippo signaling pathway - fly 14/461 90/7206 0.00159312323855 ko04310 Wnt signaling pathway 23/461 181/7206 0.00166821513938 ko04550 Signaling pathways regulating pluripotency of stem cells 21/461 165/7206 0.00203781701236 ko03410 Base excision repair 8/461 38/7206 0.00234562936312 ko04919 Thyroid hormone signaling pathway 19/461 143/7206 0.00258758665601 ko05220 Chronic myeloid leukemia 13/461 85/7206 0.00270121208909 ko05203 Viral carcinogenesis 30/461 277/7206 0.00380588252376 ko03008 Ribosome biogenesis in eukaryotes 12/461 79/7206 0.00411460538869 ko05012 Parkinson's disease 2/461 155/7206 0.00419610290512 ko00190 Oxidative phosphorylation 1/461 127/7206 0.00491096019126 ko05216 Thyroid cancer 7/461 34/7206 0.00497199388043 ko05010 Alzheimer's disease 4/461 202/7206 0.00520420171571 ko05200 Pathways in cancer 47/461 492/7206 0.00536625106699 ko04142 Lysosome 2/461 151/7206 0.00615282892574 ko05212 Pancreatic cancer 12/461 83/7206 0.006174751901 ko04724 Glutamatergic synapse 2/461 152/7206 0.00626521126571 ko04911 Insulin secretion 1/461 117/7206 0.00676099229752 ko04723 Retrograde endocannabinoid signaling 3/461 175/7206 0.00694367604785 ko05166 HTLV-I infection 30/461 292/7206 0.00972697877453 ko05217 Basal cell carcinoma 10/461 68/7206 0.0106293511562 ko03430 Mismatch repair 5/461 22/7206 0.0111327276613 ko04713 Circadian entrainment 2/461 136/7206 0.0120790270128 ko04392 Hippo signaling pathway -multiple species 6/461 31/7206 0.0124155874272 ko05202 Transcriptional misregulation in cancer 21/461 188/7206 0.0142851642831 ko01200 Carbon metabolism 2/461 128/7206 0.016958357426 ko05224 Breast cancer 19/461 174/7206 0.0184722213233 ko05168 Herpes simplex infection 20/461 182/7206 0.0196639315042 ko04722 Neurotrophin signaling pathway 18/461 160/7206 0.0202113203789 ko04260 Cardiac muscle contraction 1/461 98/7206 0.020667529553 ko04914 Progesterone-mediated oocyte maturation 13/461 104/7206 0.0229151180095 ko04022 cGMP-PKG signaling pathway 6/461 216/7206 0.0232476299453 ko00310 Lysine degradation 10/461 73/7206 0.0249249674806 ko00270 Cysteine and methionine metabolism 7/461 47/7206 0.0284826678429 ko04340 Hedgehog signaling pathway 8/461 58/7206 0.0301584717745 ko04341 Hedgehog signaling pathway - fly 6/461 38/7206 0.0319759510756 ko04728 Dopaminergic synapse 5/461 185/7206 0.0327085812326 ko05223 Non-small cell lung cancer 9/461 66/7206 0.0361957491329 ko00514 Other types of O-glycan biosynthesis 5/461 30/7206 0.0396430482204 ko05131 Shigellosis 10/461 82/7206 0.0397454000741 ko04261 Adrenergic signaling in cardiomyocytes 6/461 205/7206 0.0410533535325 ko04670 Leukocyte transendothelial migration 16/461 151/7206 0.0420926985714 ko01230 Biosynthesis of amino acids 1/461 85/7206 0.0430678666273 ko04218 Cellular senescence 18/461 177/7206 0.0431966490175 ko04146 Peroxisome 1/461 89/7206 0.0450395667401 ko05323 Rheumatoid arthritis 1/461 89/7206 0.0450395667401 ko04725 Cholinergic synapse 4/461 160/7206 0.0473282235165 ko04727 GABAergic synapse 2/461 110/7206 0.0473753197564 ko05032 Morphine addiction 2/461 110/7206 0.0473753197564 ko03015 mRNA surveillance pathway 11/461 93/7206 0.0496413242168