ko pathway ratio_in_study ratio_in_pop p_value ko04110 Cell cycle 35/447 145/7206 1.30482256152e-12 ko04111 Cell cycle - yeast 25/447 90/7206 9.06893208173e-11 ko04080 Neuroactive ligand-receptor interaction 3/447 423/7206 8.10821545018e-09 ko03030 DNA replication 13/447 38/7206 2.1941199766e-07 ko03440 Homologous recombination 13/447 41/7206 6.01127482019e-07 ko04113 Meiosis - yeast 17/447 70/7206 8.11921585459e-07 ko04520 Adherens junction 20/447 103/7206 3.91232302609e-06 ko00240 Pyrimidine metabolism 19/447 110/7206 3.88971573821e-05 ko03460 Fanconi anemia pathway 12/447 51/7206 4.82559081973e-05 ko04530 Tight junction 30/447 228/7206 7.1538657572e-05 ko03410 Base excision repair 10/447 38/7206 7.45899569989e-05 ko04330 Notch signaling pathway 13/447 62/7206 8.53545187761e-05 ko04390 Hippo signaling pathway 25/447 188/7206 0.000293724402642 ko04310 Wnt signaling pathway 23/447 181/7206 0.00086752210648 ko03018 RNA degradation 13/447 84/7206 0.00184466862773 ko05206 MicroRNAs in cancer 22/447 177/7206 0.00219830636955 ko04013 MAPK signaling pathway - fly 16/447 115/7206 0.00244206958336 ko05200 Pathways in cancer 47/447 492/7206 0.00254744070924 ko03008 Ribosome biogenesis in eukaryotes 12/447 79/7206 0.00320233864703 ko03040 Spliceosome 18/447 145/7206 0.00449217333412 ko00190 Oxidative phosphorylation 1/447 127/7206 0.00466915733531 ko03013 RNA transport 20/447 166/7206 0.00472347062355 ko05220 Chronic myeloid leukemia 12/447 85/7206 0.0058784260953 ko05012 Parkinson's disease 2/447 155/7206 0.00612390727289 ko04919 Thyroid hormone signaling pathway 17/447 143/7206 0.00810979554652 ko04670 Leukocyte transendothelial migration 18/447 151/7206 0.00909487802474 ko03430 Mismatch repair 5/447 22/7206 0.00980855193931 ko04392 Hippo signaling pathway -multiple species 6/447 31/7206 0.0107562600744 ko04391 Hippo signaling pathway - fly 12/447 90/7206 0.0122810574537 ko04020 Calcium signaling pathway 7/447 265/7206 0.0128027034006 ko04060 Cytokine-cytokine receptor interaction 4/447 191/7206 0.0138385486511 ko05216 Thyroid cancer 6/447 34/7206 0.0167997009173 ko05211 Renal cell carcinoma 12/447 96/7206 0.0171621393746 ko05212 Pancreatic cancer 11/447 83/7206 0.0177591733769 ko05166 HTLV-I infection 28/447 292/7206 0.0184133177298 ko00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin 5/447 26/7206 0.0199852848672 ko04550 Signaling pathways regulating pluripotency of stem cells 18/447 165/7206 0.0202917148253 ko05100 Bacterial invasion of epithelial cells 12/447 99/7206 0.020617416748 ko00230 Purine metabolism 20/447 194/7206 0.0226557560369 ko04723 Retrograde endocannabinoid signaling 4/447 175/7206 0.0253384351932 ko04142 Lysosome 3/447 151/7206 0.0253734281677 ko04724 Glutamatergic synapse 3/447 152/7206 0.0255191148163 ko05034 Alcoholism 7/447 238/7206 0.0287197610203 ko04722 Neurotrophin signaling pathway 17/447 160/7206 0.029037918696 ko04022 cGMP-PKG signaling pathway 6/447 216/7206 0.0309182415447 ko04260 Cardiac muscle contraction 1/447 98/7206 0.0312227619967 ko00670 One carbon pool by folate 4/447 20/7206 0.0320221596559 ko05131 Shigellosis 10/447 82/7206 0.0346174095883 ko01523 Antifolate resistance 5/447 30/7206 0.0353712332497 ko00514 Other types of O-glycan biosynthesis 5/447 30/7206 0.0353712332497 ko05217 Basal cell carcinoma 9/447 68/7206 0.0362754238835 ko04218 Cellular senescence 18/447 177/7206 0.0380907639476 ko05169 Epstein-Barr virus infection 20/447 206/7206 0.0399416135726 ko04921 Oxytocin signaling pathway 6/447 209/7206 0.0407886225075 ko05168 Herpes simplex infection 18/447 182/7206 0.0427114374946 ko04146 Peroxisome 1/447 89/7206 0.0435930747006 ko05323 Rheumatoid arthritis 1/447 89/7206 0.0435930747006 ko04728 Dopaminergic synapse 5/447 185/7206 0.0437855494551 ko04011 MAPK signaling pathway - yeast 7/447 53/7206 0.0438964168367 ko05031 Amphetamine addiction 1/447 91/7206 0.0446367928615 ko04725 Cholinergic synapse 4/447 160/7206 0.0462289511142 ko04713 Circadian entrainment 3/447 136/7206 0.0477142535226 ko04911 Insulin secretion 2/447 117/7206 0.0493574411787