ko pathway ratio_in_study ratio_in_pop p_value ko04060 Cytokine-cytokine receptor interaction 30/370 191/7206 3.00402244571e-08 ko05164 Influenza A 26/370 167/7206 3.10247673271e-07 ko04672 Intestinal immune network for IgA production 10/370 37/7206 1.12939151737e-05 ko04380 Osteoclast differentiation 20/370 134/7206 1.41576980802e-05 ko04621 NOD-like receptor signaling pathway 22/370 157/7206 1.48527844012e-05 ko05145 Toxoplasmosis 19/370 126/7206 2.00073019959e-05 ko04658 Th1 and Th2 cell differentiation 16/370 96/7206 2.56663179291e-05 ko00350 Tyrosine metabolism 9/370 33/7206 2.89091140927e-05 ko00140 Steroid hormone biosynthesis 10/370 41/7206 3.02256521105e-05 ko04622 RIG-I-like receptor signaling pathway 12/370 62/7206 5.88893959238e-05 ko05140 Leishmaniasis 13/370 75/7206 9.69962356525e-05 ko04623 Cytosolic DNA-sensing pathway 9/370 41/7206 0.000182238798202 ko04659 Th17 cell differentiation 15/370 106/7206 0.000306539571416 ko05162 Measles 16/370 120/7206 0.000388964019977 ko05321 Inflammatory bowel disease (IBD) 10/370 56/7206 0.000481874426895 ko00643 Styrene degradation 3/370 4/7206 0.00051678838643 ko05323 Rheumatoid arthritis 13/370 89/7206 0.000561128901082 ko04064 NF-kappa B signaling pathway 13/370 96/7206 0.00116372257066 ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis 3/370 5/7206 0.00124272592297 ko04657 IL-17 signaling pathway 12/370 87/7206 0.0015177211748 ko05168 Herpes simplex infection 20/370 182/7206 0.00167118404308 ko05332 Graft-versus-host disease 5/370 18/7206 0.00170743994667 ko05150 Staphylococcus aureus infection 7/370 36/7206 0.00203574192643 ko05160 Hepatitis C 17/370 153/7206 0.0023786563974 ko05034 Alcoholism 3/370 238/7206 0.00252383658421 ko00120 Primary bile acid biosynthesis 5/370 20/7206 0.00283826619309 ko00590 Arachidonic acid metabolism 8/370 52/7206 0.00462912061446 ko04668 TNF signaling pathway 14/370 120/7206 0.00492486943572 ko04620 Toll-like receptor signaling pathway 12/370 100/7206 0.00493986069066 ko00051 Fructose and mannose metabolism 7/370 42/7206 0.00505001487492 ko00565 Ether lipid metabolism 7/370 42/7206 0.00505001487492 ko04666 Fc gamma R-mediated phagocytosis 14/370 122/7206 0.00528266934996 ko04660 T cell receptor signaling pathway 14/370 124/7206 0.00572689848172 ko04080 Neuroactive ligand-receptor interaction 10/370 423/7206 0.00601912746336 ko05330 Allograft rejection 5/370 24/7206 0.00657097571084 ko04512 ECM-receptor interaction 10/370 79/7206 0.00683821468735 ko03040 Spliceosome 1/370 145/7206 0.00699554896897 ko05161 Hepatitis B 17/370 173/7206 0.00843165104222 ko00360 Phenylalanine metabolism 4/370 17/7206 0.00955066197158 ko04726 Serotonergic synapse 1/370 137/7206 0.0101463241033 ko04120 Ubiquitin mediated proteolysis 1/370 138/7206 0.010183716887 ko00982 Drug metabolism - cytochrome P450 6/370 37/7206 0.0105811492834 ko00950 Isoquinoline alkaloid biosynthesis 3/370 10/7206 0.0122981934126 ko03013 RNA transport 2/370 166/7206 0.0123569558613 ko05133 Pertussis 10/370 87/7206 0.0132295462492 ko04360 Axon guidance 4/370 233/7206 0.0144064664314 ko00960 Tropane, piperidine and pyridine alkaloid biosynthesis 2/370 4/7206 0.0147238594139 ko05320 Autoimmune thyroid disease 5/370 29/7206 0.0148826695998 ko00980 Metabolism of xenobiotics by cytochrome P450 6/370 40/7206 0.0153603617654 ko04640 Hematopoietic cell lineage 8/370 64/7206 0.0159882852423 ko04612 Antigen processing and presentation 9/370 77/7206 0.0165345766338 ko05340 Primary immunodeficiency 5/370 30/7206 0.0171280981642 ko05146 Amoebiasis 11/370 99/7206 0.0174613089631 ko04068 FoxO signaling pathway 16/370 167/7206 0.0187510294998 ko04610 Complement and coagulation cascades 9/370 79/7206 0.019295284689 ko04940 Type I diabetes mellitus 5/370 32/7206 0.022266972324 ko00281 Geraniol degradation 2/370 5/7206 0.0237112817417 ko05142 Chagas disease (American trypanosomiasis) 13/370 130/7206 0.0238165337578 ko05012 Parkinson's disease 2/370 155/7206 0.0250226927955 ko04630 Jak-STAT signaling pathway 13/370 132/7206 0.0250340732142 ko05144 Malaria 6/370 45/7206 0.0263291601131 ko04933 AGE-RAGE signaling pathway in diabetic complications 13/370 135/7206 0.0273118162739 ko04650 Natural killer cell mediated cytotoxicity 10/370 97/7206 0.0323440843477 ko04110 Cell cycle 2/370 145/7206 0.0346306435408 ko05204 Chemical carcinogenesis 6/370 48/7206 0.0349215912897 ko05131 Shigellosis 9/370 82/7206 0.0369809059795 ko05152 Tuberculosis 16/370 187/7206 0.0418754916364 ko04514 Cell adhesion molecules (CAMs) 12/370 130/7206 0.0425896466735 ko04727 GABAergic synapse 1/370 110/7206 0.0455908742909 ko04114 Oocyte meiosis 2/370 139/7206 0.0490526229426