ko pathway ratio_in_study ratio_in_pop p_value ko04060 Cytokine-cytokine receptor interaction 41/537 191/7206 3.38460265991e-10 ko04621 NOD-like receptor signaling pathway 36/537 157/7206 6.20905512952e-10 ko05164 Influenza A 37/537 167/7206 1.00133951258e-09 ko05340 Primary immunodeficiency 13/537 30/7206 6.96747013772e-08 ko04658 Th1 and Th2 cell differentiation 24/537 96/7206 8.32703511773e-08 ko04380 Osteoclast differentiation 29/537 134/7206 1.16666184595e-07 ko05140 Leishmaniasis 20/537 75/7206 3.26266814564e-07 ko05145 Toxoplasmosis 27/537 126/7206 3.961873643e-07 ko00120 Primary bile acid biosynthesis 10/537 20/7206 4.53900983128e-07 ko04064 NF-kappa B signaling pathway 22/537 96/7206 1.44722860301e-06 ko04659 Th17 cell differentiation 23/537 106/7206 2.3024324807e-06 ko04672 Intestinal immune network for IgA production 12/537 37/7206 8.53667729729e-06 ko05162 Measles 23/537 120/7206 2.04578975624e-05 ko04650 Natural killer cell mediated cytotoxicity 20/537 97/7206 2.34065881032e-05 ko04612 Antigen processing and presentation 17/537 77/7206 3.80378150851e-05 ko05321 Inflammatory bowel disease (IBD) 14/537 56/7206 4.27951545396e-05 ko05133 Pertussis 18/537 87/7206 5.68018583409e-05 ko03013 RNA transport 1/537 166/7206 6.51568812215e-05 ko04662 B cell receptor signaling pathway 18/537 88/7206 6.65689570719e-05 ko05168 Herpes simplex infection 29/537 182/7206 7.90903322825e-05 ko00350 Tyrosine metabolism 10/537 33/7206 9.35754920037e-05 ko04660 T cell receptor signaling pathway 22/537 124/7206 0.000166461869041 ko05150 Staphylococcus aureus infection 10/537 36/7206 0.000209575237272 ko05330 Allograft rejection 8/537 24/7206 0.000227619892947 ko05142 Chagas disease (American trypanosomiasis) 22/537 130/7206 0.000251944054686 ko04668 TNF signaling pathway 21/537 120/7206 0.000267477662868 ko04630 Jak-STAT signaling pathway 22/537 132/7206 0.000300206731667 ko03040 Spliceosome 1/537 145/7206 0.000311498227508 ko00590 Arachidonic acid metabolism 12/537 52/7206 0.000338466290707 ko04620 Toll-like receptor signaling pathway 18/537 100/7206 0.000364089260514 ko04217 Necroptosis 27/537 178/7206 0.0003879647317 ko00140 Steroid hormone biosynthesis 10/537 41/7206 0.000658654107699 ko04623 Cytosolic DNA-sensing pathway 10/537 41/7206 0.000658654107699 ko04666 Fc gamma R-mediated phagocytosis 20/537 122/7206 0.000697986516486 ko05152 Tuberculosis 27/537 187/7206 0.000939384764515 ko05320 Autoimmune thyroid disease 8/537 29/7206 0.000952620924535 ko03010 Ribosome 1/537 129/7206 0.000991827566557 ko05310 Asthma 6/537 17/7206 0.00101203758138 ko05146 Amoebiasis 17/537 99/7206 0.00136327856466 ko05332 Graft-versus-host disease 6/537 18/7206 0.00142355032903 ko05160 Hepatitis C 23/537 153/7206 0.00146747512515 ko05034 Alcoholism 6/537 238/7206 0.00152029996906 ko00643 Styrene degradation 3/537 4/7206 0.00155527086833 ko04622 RIG-I-like receptor signaling pathway 12/537 62/7206 0.00178702564706 ko04610 Complement and coagulation cascades 14/537 79/7206 0.00186827274737 ko04110 Cell cycle 2/537 145/7206 0.00199249126935 ko05161 Hepatitis B 24/537 173/7206 0.00291157349521 ko00051 Fructose and mannose metabolism 9/537 42/7206 0.00319644604003 ko04611 Platelet activation 23/537 163/7206 0.00352895954095 ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis 3/537 5/7206 0.0036728124025 ko04710 Circadian rhythm 9/537 43/7206 0.0037820968077 ko00950 Isoquinoline alkaloid biosynthesis 4/537 10/7206 0.00445506161299 ko04360 Axon guidance 7/537 233/7206 0.00510943867426 ko05144 Malaria 9/537 45/7206 0.00520310357025 ko00360 Phenylalanine metabolism 5/537 17/7206 0.0065728743159 ko05323 Rheumatoid arthritis 14/537 89/7206 0.0067389459929 ko04640 Hematopoietic cell lineage 11/537 64/7206 0.00705813392938 ko04390 Hippo signaling pathway 5/537 188/7206 0.0071157068964 ko04062 Chemokine signaling pathway 25/537 201/7206 0.00946656698085 ko04068 FoxO signaling pathway 22/537 167/7206 0.010145568441 ko00592 alpha-Linolenic acid metabolism 5/537 19/7206 0.0109112900654 ko05167 Kaposi's sarcoma-associated herpesvirus infection 24/537 191/7206 0.011079460592 ko04657 IL-17 signaling pathway 13/537 87/7206 0.0128545871231 ko04664 Fc epsilon RI signaling pathway 12/537 77/7206 0.0134655682334 ko03015 mRNA surveillance pathway 1/537 93/7206 0.014623760515 ko05132 Salmonella infection 14/537 98/7206 0.0176480607186 ko04137 Mitophagy - animal 12/537 82/7206 0.0193457348633 ko04080 Neuroactive ligand-receptor interaction 20/537 423/7206 0.0276978480245 ko04940 Type I diabetes mellitus 6/537 32/7206 0.0285757559161 ko05231 Choline metabolism in cancer 17/537 134/7206 0.0289964881306 ko04933 AGE-RAGE signaling pathway in diabetic complications 17/537 135/7206 0.0299610079922 ko00960 Tropane, piperidine and pyridine alkaloid biosynthesis 2/537 4/7206 0.0300609421371 ko00380 Tryptophan metabolism 8/537 50/7206 0.0300854958099 ko04310 Wnt signaling pathway 6/537 181/7206 0.030380410407 ko00920 Sulfur metabolism 3/537 10/7206 0.0332623133031 ko00565 Ether lipid metabolism 7/537 42/7206 0.0338224023929 ko04917 Prolactin signaling pathway 12/537 87/7206 0.0362290162539 ko04670 Leukocyte transendothelial migration 18/537 151/7206 0.0411764866003 ko04514 Cell adhesion molecules (CAMs) 16/537 130/7206 0.0417830852303 ko04210 Apoptosis 21/537 180/7206 0.0422185405075 ko04120 Ubiquitin mediated proteolysis 4/537 138/7206 0.0468340593881 ko04145 Phagosome 19/537 162/7206 0.0472463417085 ko04512 ECM-receptor interaction 11/537 79/7206 0.0472481757005 ko00281 Geraniol degradation 2/537 5/7206 0.0476530286272