ko pathway ratio_in_study ratio_in_pop p_value ko04080 Neuroactive ligand-receptor interaction 37/236 423/7206 2.78386371781e-08 ko04713 Circadian entrainment 19/236 136/7206 7.45804118462e-08 ko04724 Glutamatergic synapse 19/236 152/7206 4.46733760466e-07 ko04727 GABAergic synapse 16/236 110/7206 4.73138217918e-07 ko05031 Amphetamine addiction 14/236 91/7206 1.25739173279e-06 ko05033 Nicotine addiction 11/236 56/7206 1.49150896625e-06 ko04728 Dopaminergic synapse 20/236 185/7206 2.29197661276e-06 ko04070 Phosphatidylinositol signaling system 14/236 112/7206 1.53294523074e-05 ko04020 Calcium signaling pathway 23/236 265/7206 1.67241550165e-05 ko04721 Synaptic vesicle cycle 11/236 80/7206 5.24436390272e-05 ko04725 Cholinergic synapse 16/236 160/7206 6.38009917611e-05 ko04720 Long-term potentiation 12/236 99/7206 8.52059550018e-05 ko05032 Morphine addiction 12/236 110/7206 0.000235854212777 ko04723 Retrograde endocannabinoid signaling 15/236 175/7206 0.000587218587385 ko04730 Long-term depression 9/236 78/7206 0.000946566332086 ko04745 Phototransduction - fly 6/236 38/7206 0.00132620927868 ko04911 Insulin secretion 11/236 117/7206 0.00149816666674 ko04010 MAPK signaling pathway 21/236 321/7206 0.00207245006242 ko04925 Aldosterone synthesis and secretion 10/236 105/7206 0.00221291979962 ko05014 Amyotrophic lateral sclerosis (ALS) 8/236 74/7206 0.00274457255701 ko05110 Vibrio cholerae infection 7/236 63/7206 0.00429010562826 ko04740 Olfactory transduction 8/236 80/7206 0.00446386534259 ko04726 Serotonergic synapse 11/236 137/7206 0.00515950881618 ko04024 cAMP signaling pathway 18/236 279/7206 0.00531977152046 ko04744 Phototransduction 5/236 36/7206 0.0059383054253 ko05166 HTLV-I infection 2/236 292/7206 0.00634737592747 ko04930 Type II diabetes mellitus 6/236 54/7206 0.00803345081852 ko02010 ABC transporters 5/236 39/7206 0.00837756512237 ko04921 Oxytocin signaling pathway 14/236 209/7206 0.00938740342262 ko04966 Collecting duct acid secretion 4/236 26/7206 0.0095075044846 ko05030 Cocaine addiction 7/236 73/7206 0.00959551370256 ko05120 Epithelial cell signaling in Helicobacter pylori infection 8/236 92/7206 0.0102629809066 ko04710 Circadian rhythm 5/236 43/7206 0.0126045557213 ko04014 Ras signaling pathway 17/236 279/7206 0.0143921816142 ko04626 Plant-pathogen interaction 3/236 18/7206 0.0196695218832 ko00680 Methane metabolism 4/236 34/7206 0.0240726791302 ko05323 Rheumatoid arthritis 7/236 89/7206 0.0262123085288 ko00562 Inositol phosphate metabolism 7/236 89/7206 0.0262123085288 ko02025 Biofilm formation - Pseudomonas aeruginosa 1/236 1/7206 0.0327504857065 ko00250 Alanine, aspartate and glutamate metabolism 4/236 38/7206 0.034642170448 ko04970 Salivary secretion 7/236 95/7206 0.035721828251 ko05164 Influenza A 1/236 167/7206 0.0453962970541 ko04742 Taste transduction 5/236 61/7206 0.0487014421003