ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	188/1107	423/7206	1.25038594633e-49
ko04724	Glutamatergic synapse	78/1107	152/7206	1.25708289199e-25
ko05033	Nicotine addiction	43/1107	56/7206	1.26995205024e-24
ko04721	Synaptic vesicle cycle	52/1107	80/7206	6.43599145994e-24
ko05032	Morphine addiction	58/1107	110/7206	4.47423236369e-20
ko04713	Circadian entrainment	65/1107	136/7206	2.13486446295e-19
ko04728	Dopaminergic synapse	77/1107	185/7206	2.67646660608e-18
ko04727	GABAergic synapse	54/1107	110/7206	5.81288881222e-17
ko04725	Cholinergic synapse	67/1107	160/7206	3.17136067595e-16
ko04020	Calcium signaling pathway	91/1107	265/7206	5.31753224161e-15
ko04024	cAMP signaling pathway	94/1107	279/7206	7.16268866903e-15
ko04723	Retrograde endocannabinoid signaling	67/1107	175/7206	6.31927385523e-14
ko04911	Insulin secretion	51/1107	117/7206	1.81326660526e-13
ko04742	Taste transduction	34/1107	61/7206	3.22250901678e-13
ko04921	Oxytocin signaling pathway	74/1107	209/7206	3.49494453098e-13
ko04726	Serotonergic synapse	52/1107	137/7206	6.38015317553e-11
ko04970	Salivary secretion	41/1107	95/7206	6.48543402036e-11
ko04261	Adrenergic signaling in cardiomyocytes	67/1107	205/7206	3.46988470494e-10
ko03040	Spliceosome	1/1107	145/7206	1.38193120659e-09
ko05203	Viral carcinogenesis	12/1107	277/7206	4.51701637904e-09
ko05031	Amphetamine addiction	36/1107	91/7206	1.6123051102e-08
ko05168	Herpes simplex infection	5/1107	182/7206	3.03786519044e-08
ko04720	Long-term potentiation	37/1107	99/7206	6.0379327693e-08
ko04540	Gap junction	44/1107	128/7206	7.3594742336e-08
ko05164	Influenza A	5/1107	167/7206	3.17484115165e-07
ko05322	Systemic lupus erythematosus	4/1107	151/7206	4.97013195407e-07
ko04120	Ubiquitin mediated proteolysis	3/1107	138/7206	5.04204740071e-07
ko04966	Collecting duct acid secretion	15/1107	26/7206	8.28434665434e-07
ko04740	Olfactory transduction	30/1107	80/7206	9.88378894652e-07
ko04022	cGMP-PKG signaling pathway	61/1107	216/7206	1.11237911699e-06
ko04060	Cytokine-cytokine receptor interaction	8/1107	191/7206	1.18127086552e-06
ko04971	Gastric acid secretion	34/1107	98/7206	1.62776623987e-06
ko04360	Axon guidance	64/1107	233/7206	1.75160001851e-06
ko03013	RNA transport	6/1107	166/7206	1.78800841998e-06
ko05030	Cocaine addiction	27/1107	73/7206	4.65533984146e-06
ko04744	Phototransduction	17/1107	36/7206	6.14956104894e-06
ko04730	Long-term depression	28/1107	78/7206	8.17995137958e-06
ko04925	Aldosterone synthesis and secretion	34/1107	105/7206	1.33745590925e-05
ko04010	MAPK signaling pathway	78/1107	321/7206	1.70611330872e-05
ko04621	NOD-like receptor signaling pathway	7/1107	157/7206	2.57100898765e-05
ko04924	Renin secretion	29/1107	86/7206	2.60015617244e-05
ko04610	Complement and coagulation cascades	1/1107	79/7206	5.2220857087e-05
ko04514	Cell adhesion molecules (CAMs)	38/1107	130/7206	6.19208914912e-05
ko05014	Amyotrophic lateral sclerosis (ALS)	25/1107	74/7206	6.57750397214e-05
ko05169	Epstein-Barr virus infection	13/1107	206/7206	7.8002000063e-05
ko04612	Antigen processing and presentation	1/1107	77/7206	8.18686729422e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	26/1107	79/7206	0.000100444369086
ko04141	Protein processing in endoplasmic reticulum	11/1107	184/7206	0.000110490164231
ko05110	Vibrio cholerae infection	22/1107	63/7206	0.000122351352602
ko04964	Proximal tubule bicarbonate reclamation	13/1107	29/7206	0.000150798392712
ko04745	Phototransduction - fly	15/1107	38/7206	0.000268162548854
ko04972	Pancreatic secretion	32/1107	111/7206	0.000268568756657
ko04070	Phosphatidylinositol signaling system	32/1107	112/7206	0.000300164485758
ko04260	Cardiac muscle contraction	29/1107	98/7206	0.000322158269303
ko04961	Endocrine and other factor-regulated calcium reabsorption	20/1107	59/7206	0.000363681425075
ko05161	Hepatitis B	11/1107	173/7206	0.000382533747437
ko04110	Cell cycle	8/1107	145/7206	0.000406486366052
ko03008	Ribosome biogenesis in eukaryotes	2/1107	79/7206	0.000412490817924
ko04976	Bile secretion	25/1107	80/7206	0.000434245797563
ko05140	Leishmaniasis	2/1107	75/7206	0.000596627646915
ko04014	Ras signaling pathway	64/1107	279/7206	0.000662839463087
ko05162	Measles	6/1107	120/7206	0.000754967838388
ko05414	Dilated cardiomyopathy	31/1107	112/7206	0.000798374588763
ko04214	Apoptosis - fly	2/1107	72/7206	0.000881874345912
ko04064	NF-kappa B signaling pathway	4/1107	96/7206	0.000884430623718
ko04371	Apelin signaling pathway	44/1107	177/7206	0.000955717166001
ko05166	HTLV-I infection	26/1107	292/7206	0.00117959774786
ko04978	Mineral absorption	14/1107	40/7206	0.00171977724698
ko05205	Proteoglycans in cancer	24/1107	271/7206	0.00188820987909
ko00240	Pyrimidine metabolism	6/1107	110/7206	0.00197124169295
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1107	14/7206	0.00251677469153
ko04072	Phospholipase D signaling pathway	46/1107	197/7206	0.00256497072717
ko04640	Hematopoietic cell lineage	2/1107	64/7206	0.00279084798776
ko04626	Plant-pathogen interaction	8/1107	18/7206	0.00313319446754
ko04750	Inflammatory mediator regulation of TRP channels	31/1107	122/7206	0.003364572282
ko04217	Necroptosis	14/1107	178/7206	0.00420244780241
ko04630	Jak-STAT signaling pathway	9/1107	132/7206	0.00468553011795
ko05410	Hypertrophic cardiomyopathy (HCM)	26/1107	100/7206	0.00496133578484
ko01200	Carbon metabolism	9/1107	128/7206	0.00617786133316
ko04923	Regulation of lipolysis in adipocytes	21/1107	77/7206	0.00634687970932
ko04915	Estrogen signaling pathway	32/1107	131/7206	0.00663911789384
ko03420	Nucleotide excision repair	1/1107	46/7206	0.00692916445233
ko04146	Peroxisome	5/1107	89/7206	0.00725169199911
ko05321	Inflammatory bowel disease (IBD)	2/1107	56/7206	0.00866300829251
ko01524	Platinum drug resistance	4/1107	76/7206	0.0100092047664
ko04657	IL-17 signaling pathway	5/1107	87/7206	0.0101470153311
ko03022	Basal transcription factors	1/1107	44/7206	0.0104282985309
ko00071	Fatty acid degradation	1/1107	45/7206	0.0108175885869
ko04932	Non-alcoholic fatty liver disease (NAFLD)	16/1107	182/7206	0.012019250319
ko00280	Valine, leucine and isoleucine degradation	2/1107	54/7206	0.0126334788714
ko00480	Glutathione metabolism	2/1107	55/7206	0.0129743980159
ko03018	RNA degradation	5/1107	84/7206	0.013931401634
ko00310	Lysine degradation	4/1107	73/7206	0.0139834266481
ko04668	TNF signaling pathway	9/1107	120/7206	0.014602580105
ko04922	Glucagon signaling pathway	30/1107	128/7206	0.0178970961647
ko05131	Shigellosis	5/1107	82/7206	0.019466201442
ko04330	Notch signaling pathway	3/1107	62/7206	0.0197575951549
ko04622	RIG-I-like receptor signaling pathway	3/1107	62/7206	0.0197575951549
ko04658	Th1 and Th2 cell differentiation	7/1107	96/7206	0.0227135426392
ko04270	Vascular smooth muscle contraction	34/1107	154/7206	0.0236213576461
ko05133	Pertussis	6/1107	87/7206	0.0243825031846
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1107	40/7206	0.0244246949079
ko00260	Glycine, serine and threonine metabolism	2/1107	48/7206	0.0262576301576
ko00380	Tryptophan metabolism	2/1107	50/7206	0.0275647357915
ko05120	Epithelial cell signaling in Helicobacter pylori infection	22/1107	92/7206	0.0283332529965
ko04974	Protein digestion and absorption	23/1107	96/7206	0.0310775782806
ko05215	Prostate cancer	9/1107	111/7206	0.0329572594248
ko05220	Chronic myeloid leukemia	6/1107	85/7206	0.0329798961698
ko00500	Starch and sucrose metabolism	1/1107	35/7206	0.0340735600693
ko05145	Toxoplasmosis	11/1107	126/7206	0.0342242022437
ko04115	p53 signaling pathway	5/1107	74/7206	0.03523451221
ko00982	Drug metabolism - cytochrome P450	1/1107	37/7206	0.0356357346557
ko04620	Toll-like receptor signaling pathway	8/1107	100/7206	0.0363875103812
ko04930	Type II diabetes mellitus	14/1107	54/7206	0.0371625914839
ko05144	Malaria	2/1107	45/7206	0.0377329856962
ko04142	Lysosome	14/1107	151/7206	0.0392023819392
ko04933	AGE-RAGE signaling pathway in diabetic complications	12/1107	135/7206	0.039473801885
ko04512	ECM-receptor interaction	19/1107	79/7206	0.040117040829
ko04015	Rap1 signaling pathway	55/1107	278/7206	0.0415626025045
ko05418	Fluid shear stress and atherosclerosis	17/1107	173/7206	0.0421198869042
ko04145	Phagosome	34/1107	162/7206	0.0476176283868
ko04140	Autophagy - animal	16/1107	164/7206	0.0478814945664